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12 Cards in this Set
- Front
- Back
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What are some hyperactive oncogenic proteins made in normal amounts due to mutations in the coding sewuence?
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Ras
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What are some oncogenic proteins greatly over produced because of gene Amplification?
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N-Myc--> neuroblastomas
Her2 Receptor--> breast cancer |
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Due to chromosomal rearrangement normal proteins are induced by regulatory DNA sequence to be overproduced?
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c-Myc
cyclin D BCL-2 |
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Is Ras bound to the membrane?
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Yes
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Why is the Ras mutant permanently activted?
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inability to to hydrolyze GTP
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What does EGF and TGF-alpha ligands bind to?
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EGF Receptors
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What genes and associated diseases are placed under control of a strong transcriptional regulator following a translocation?
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1. c-Myc : Burkitt Lymphoma
2. Cyclin D: MCL 3. BCL-2: Follicular lymphoma |
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What genes are FUSED after a translocation causing Chronic Myelocytic Leukemia?
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BCR and ABL ---> bad protein kinase
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What is the Philadelphia chromosome?
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the fusion of chromosome 22 and 9
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What do SMAD's in the TGF-Beta pathway transcribe?
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CDK inhibitors (INK:p15)
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The mutated TGF-Beta pathway is caused by:
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1. Insensitivity to growth signals: loss of p15 CDK inhibitor
2. Loss of PAI-1 --> metastasis |
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What do tumors secrete to recruit blood vessels?
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1. TGF-alpha
2. FGF 3. VEGF |
