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29 Cards in this Set

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The rhythm nearly proved contagious
B1 -> Thiamine
B2 -> Riboflavin
B3 -> Niacin
B4 -> Pyrodoxine
B5 -> Cobalamin
CE Thiamine
TPP(Thiamine Pyrophosphate)
Function of TPP:
1- Oxidative decarboxylation of alpha keto acids.
2- Transketolase.
Deficiency thiamine:
1- Beriberi.
2- Wernicke-Korsakoff.
CE Riboflavin
FMN
FAD
FMN function
Oxidative deamination of some amino acids.
Respiratory chain.
FAD function
Carbs metabolism
Lipids metabolism
Some AAs metabolism
Riboflavin deficiency
1- Stomatitis,
2- Glossitis.
3- Agular stomatitis.
4- Scally dermatitis.
Manufacture of Niacin from tryptophan requires
Pyrodoxine
CE Niacin
NAD
NADP
NMN
Function NAD and NADP
Hydrogen carriers
NAD dependent enzymes:
Lactate dehydrogenase
Pyruvate dehydrogenase
NADP dependent enzymes:
Glucose-6-P dehydrogenase
Folate reductase
Niacin deficiency
Pellagra:
1- Dementia.
2- Diarrhea.
3- Dermatitis.
CE Pyrodoxine
PLP(pyrodoxal phosphate)
Function PLP
1- Deamination and Decarboxylation of some amino acid
GABA and Serotonin.
2- Heme biosynthesis.
3- Tryptophan -> Niacin.
4- Ceramide and sphingolipids.
5- Carbohydrate metabolism.
Deficiency pyridoxine
1- Microcytic hypochromic anemia.
2- Convulsions.
3- Pellagra manifestations.
an enzyme containing selenium
Glutathione peroxidase
co-carboxylase
Biotin
Deficiency biotin
Developmental delay and neurological disorders
Folic acid composition
Pteridine ring, PABA, Glutamate
A competitive inhibitor of dihydrofolate reductase
Methotrexate
Antibacterial drugs depending on folate synthesis by bacteria
Sulfonamides
Structure of cobalamin
Four corrin rings connected to a cobalt ion
Cobalamin synthesized in the body is of no biological importance
absorption only occurs in the small intestine
CE Cobalamin
Cobamide
Hydrolytic products pantothenic acid:
1- Pantoic acid + Beta alanine.
CE pantothenic acid
CoA
Lipoic acid
intermediate in oxidative decarboxylation of alpha keto acids