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5 Cards in this Set

  • Front
  • Back
lymphoid stem cell
bone marrow
germ line H and L chains
no Ig on mbr
Pro B cell
H-chain: DJ rearranged
pro-BCR on mbr:

2 partial H chains expressed on surface with calnexin
Pre B cell
H chain: V(D)J rearranged
pre-BCR on mbr:

IgM H chain complete; expressed on mbr with surrogate L chain (lambda 5)
immature B cell
H chain: complete
L chain: VJ rearranged
IgM expressed on mbr
cont to mature if doesnt react with "self"
mature B cell
expression of IgM and IgD on mbr