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5 Cards in this Set
- Front
- Back
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lymphoid stem cell
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bone marrow
germ line H and L chains no Ig on mbr |
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Pro B cell
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H-chain: DJ rearranged
pro-BCR on mbr: 2 partial H chains expressed on surface with calnexin |
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Pre B cell
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H chain: V(D)J rearranged
pre-BCR on mbr: IgM H chain complete; expressed on mbr with surrogate L chain (lambda 5) |
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immature B cell
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H chain: complete
L chain: VJ rearranged IgM expressed on mbr cont to mature if doesnt react with "self" |
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mature B cell
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expression of IgM and IgD on mbr
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