B And L 1 - Fischler, What To Know.

Front 1

What are the causes of erroneous increase in WBCs with an auto counter?

Back 1

unlysed RBCs
nucleated red cells
platelet clumping
monoclonal proteins
cryofibrinogen
cryoglobilum
heparin

Front 2

What are the causes of erroneous decrease in WBCs with an auto counter?

Back 2

smudge cells
clotting
uremia with immunosuprescents

Front 3

What is the most common cause of agranulocytosis (neutopenia)?

Back 3

drug tox

Front 4

What CD is present on all leukocytes?

Back 4

CD 45

Front 5

Name all the T cell assoc CDs

Back 5

1,3,4,5,8

Front 6

What are all the B cell assoc CDs?

Back 6

10,19,20,21,23,79a

Front 7

Stem cell and progenitor cell assoc CD?

Back 7

CD34

Front 8

Should plasma cells be present in circulating blood?

Back 8

NO

Front 9

Basophilla could mean what?

Back 9

Myeloproliferative disease

Front 10

Eosinophilla could mean what?

Back 10

Neoplastic disorders
HODGKINS LYMPHOMA

Front 11

The most common malignancy of children and adolescents?

Back 11

ALL

Front 12

ALL is the most common for who?

Back 12

The most common malignancy of children and adolescents

Front 13

What are the genetics behind ALL?

Back 13

Over 95% of cases are pos for TdT
Chrom is changed in a way also

Front 14

Testicular involvement is common in what?

Back 14

ALL

Front 15

What are the 4 things that are assoc with worse prognosis in ALL?

Back 15

Under 2 and assoc of infantile ALL with translocation of MLL gene
Presentation in adolescence or adulthood
Peripherial blood blast count is over 100,000
Presence of particular cytogenic aberrations, such as the Philly (9;22)

Front 16

What is the most common leukemia of adults in the westen world?

Back 16

CLL

Front 17

Tumor cells for CLL?

Back 17

CD 5 POS
CD 19 and 20

Front 18

What are the 2 transformations in CLL and tell me about them?

Back 18

Polymorphic Transformation- most common, polys are in the per blood, pts have worsening cytopenia and splenomegaly.

Richter Syndrome- transformation to diffuse large B cell lymphoma

With both survival is less than a year

Front 19

The most common indolent non hodgkin lymphoma in the US?

Back 19

Follicular lymphoma

Front 20

What is the genetics behind follicular lymphoma?

Back 20

t(14;18)
this leads to overexpression of BCL2 (normal cells are neg for this)

Front 21

What are the 2 subtypes of Diffuse Large B cell Lymphoma (this is a form of non hodgkin lymphoma)

Back 21

Immunodeficiency associated large B cell lymphoma- happens with severe T cell deficincy, neoplastic B cells are infected with EBV

Primary effusion lymphoma- occurs in people with aids or oldies, cells are infected with KSHV/HHV8

Front 22

Genetics behind Burkitt Lymphoma?

Back 22

translocations of the c-MYC gene on chromosome 8

Front 23

t(14;18)?

Back 23

Follucilur Lymphoma

Leads to overexpression of BCL2

Front 24

EBV infects what?

Back 24

Immunodef large B cell lymphoma- severe T cell def, it effects the B cells

Front 25

KSHV/HHV8 infects what?

Back 25

Primary effusion lymphoma- seen in oldies and aids pts

Front 26

CD11c?

Back 26

Hairy Cell

Front 27

lymphomatoid polyposis?

Back 27

mantle cell lymphoma- multifocal small bowel and colon mucosal involvement produces ...... (colon polyps)

MOST LIKELY TO SPREAD

Front 28

t(11:14)
CD5(+) and cyclin D1

Back 28

Mantle cell lymphoma

Front 29

ALK(+)
Rearrangment of ALK gene on chrom 2p23

Back 29

Anaplastic large cell lymphoma

Front 30

Genetics behind anaplastic large cell lymphoma

Back 30

ALK(+)
Rearrangment of ALK gene on chrom 2p23

Front 31

IL-6

Back 31

Multiple Myeloma
IL-6 survival dependent on this cytokine

Front 32

High IgM?

Back 32

Lymphoplasmactic lymphoma

Front 33

Tell about lymphoplasmastic lymphoma

Back 33

a B cell neoplasm that secretes IgM at high levels so it causes a hyperviscosity syndrome (waldenstrom macroglobulinemia)

Front 34

What do you need to dx Hodgkin?

Back 34

reed sternburg cell

Front 35

CDs for lymphocyte predominance for hodgkin?

Back 35

CD20(+)
CD15 and 30 (-)
EBV (-)

Front 36

CD13, CD33, CD117 in over 20% of blasts

Back 36

Acute Myeloid Leukemia

Front 37

Tell about acute myeloid leukemia
CDs?
What do you see?

Back 37

CD13, CD33, CD117 in over 20% of blasts
See Auer Rods
t(15;17)

Front 38

What are the markers for detection of acute megakaryoblastic leukemia?

Back 38

GPIIb/IIIa of vWF

Front 39

GPIIb/IIIa of vWF
CD 61!!!!!
And platelet growth factor 1b (CD41)

Back 39

acute megakaryoblastic leukemia

Front 40

Most common AML in Down Syndrome?

Back 40

acute megakaryoblastic leukemia

Front 41

acute megakaryoblastic leukemia is most likely seen in what syndrome?

Back 41

downs

Front 42

peripherial blood cytopenias is seen in what?

Back 42

myeldysplastic syndrome

Front 43

5q syndrome

Back 43

myeldysplastic syndrome

Front 44

BCR-ABL fusion gene in 100% of cases

Back 44

chronic myeloid leukemia

Front 45

genetics behind chronic myeloid leukemia?

Back 45

BCR-ABL fusion gene in 100% of cases

Front 46

genetics behind polycythemia vera?

Back 46

TK mutation at JAK2 mutation in 95% of cases

Front 47

TK mutation at JAK2 mutation in 95% of cases

Back 47

Polycythemoa vera

Front 48

S-100

Back 48

langerhans cell histocytosis

Front 49

What do the tumor cells in langerhands cell histocytosis express?

Back 49

HLA-DR
S-100
CD1a