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17 Cards in this Set
- Front
- Back
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Pilocarpine
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Muscarinic agonist
alkoloid form s.american shrub - effects - generalized muscarinic, including ocular - pupillary constiction, spasm of accommodation and fall of intraocular pressure; miosis lasts several hours. - clinical setting - glaucoma |
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Metoclopramide
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Muscarinic Agoinist
(reglan) Increase gastric emptying nad anti-ametic (dopamine receptor antagonist) Enhances Cholinergic effects Clincal - gastroparesis, anti-emetic, PO 10mg tid |
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Atropine
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Muscarinic Antagoinist
competitive antagonist of acetylcholine @ most muscarinic receptors effects- dry mouth, constipation, urinary retention, dry skin, flush, bronchodilation, mydriasis, tach, delrium MAD AS A HATTER, RED AS A BEAT, DRY AS A BONE clinical setting: stop asystole, diarrea, antidote to acetylcholinesterase toxins; pupil dilation, given po, opthalmic or via injection |
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Scopolamin
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muscarine antagonist
- taken orally or transdermally for motion sickness |
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Ipratropium
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atrovent -brochodilator for asthma and COPD used as a metered dose inhaler
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neostigmine
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reversible covalent modifier of aceylcholine esterase
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sarin
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irreversible inhibitor of acetylcholinesterase
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pralidoxime
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acetylcholinesterase rescue agent
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classes of acetylcholinesterase inhibitors and their effects
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poisoning: bronchial spasm, salivation, lacrimatin, defacation, urination, bradycardia, hypotension, muscle weekness, death in minutes to hours
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hemicholinium
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blocks choline uptake
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Adrenergic Synapse
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tyr - DOPA - DOPAMINE - NE
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Pharmacology of alpha and beta adrenergic receptors
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Beta- adenylate cyclase
alpha 2 -inhibit adenylate cyclase |
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epinepherine
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Beta agonist
increase cardiac output and systolic BP Large metabolic effect on incrase O2 consumption and blood glucose stopped anaphylactic response and code blue |
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norepinepherine
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Alpha agonist
INcrease systolic and diastolck BP less effect on cardiac output and metabolism used in hypotensive shock but is largely replaced by phenylephrine |
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dopamine
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IV infusion
Low (renal dose) dopamin, acts on the D1 receptor - used in renal failure pts with low perfusion medium and higher does has effects on alpha and beta receptors and is often used as the first pressor in most instances of shock |
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pheylephrine
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used as the first pressor in most instances of shock
alpha adenergic agonist. alos used as a nasal decongestant |
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phenoxybenzamine
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alpha receptor antabonist
- used clinically for the treatment of pheochromacytoma |
