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15 Cards in this Set

  • Front
  • Back
Substitutions on meta, para, and beta carbons promote what?
Direct acting sympathomimetics
No/very few substitutions on the phenylethylamine skeleton favor what condition?
Indirect action
Large substituents on the nitrogen of phenyethylamine
Promote beta activity
B2 selectivity is seen in what structures
hydroxyls on 3,5 carbons of ring on phenethylamine
Small substitution on nitrogen in directly acting drugs favor what type of receptor?
Alpha activity!@!
less side groups on a phenethylamine means what?
more centrally acting
COMT won't metabolize what types of structures?
Anything without a 3 or 4 OH on the phenethylamine ring. Thus increasing duration of action of drug.
MAO won't metabolize what types of structures?
Methyl substitutions on the alpha carbon due to steric hindrance. Thus increasing duration of action of drug.
Structure of a non-catechol?
Must have 2 adjacent hydroxyls in 3,4 positions on phenethylamine ring
Noncatechol with methylated alpha carbon - why is it special?
Very long lasting and favors oral effectiveness (like amphetamine)
Dobutamine, metaproterenol, terbutyline, ritodrine, albuterol
Beta agonists
Phenylephrine, metaraminol, methoxamine
Alpha1 agonists
What type of agonist would you use to stop a runny nose?
Alpha agonist - vasoconstricts
Ephedrine, amphetamine, phenylpropanolamine, cyclopentamine, tuaminoheptane, naphazoline, tetrahydrozoline
Indirectly acting sympathomimetics
Visine, vasoconstricts and helps clear up red eyes