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15 Cards in this Set
- Front
- Back
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Substitutions on meta, para, and beta carbons promote what?
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Direct acting sympathomimetics
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No/very few substitutions on the phenylethylamine skeleton favor what condition?
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Indirect action
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Large substituents on the nitrogen of phenyethylamine
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Promote beta activity
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B2 selectivity is seen in what structures
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hydroxyls on 3,5 carbons of ring on phenethylamine
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Small substitution on nitrogen in directly acting drugs favor what type of receptor?
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Alpha activity!@!
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less side groups on a phenethylamine means what?
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more centrally acting
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COMT won't metabolize what types of structures?
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Anything without a 3 or 4 OH on the phenethylamine ring. Thus increasing duration of action of drug.
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MAO won't metabolize what types of structures?
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Methyl substitutions on the alpha carbon due to steric hindrance. Thus increasing duration of action of drug.
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Structure of a non-catechol?
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Must have 2 adjacent hydroxyls in 3,4 positions on phenethylamine ring
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Noncatechol with methylated alpha carbon - why is it special?
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Very long lasting and favors oral effectiveness (like amphetamine)
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Dobutamine, metaproterenol, terbutyline, ritodrine, albuterol
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Beta agonists
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Phenylephrine, metaraminol, methoxamine
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Alpha1 agonists
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What type of agonist would you use to stop a runny nose?
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Alpha agonist - vasoconstricts
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Ephedrine, amphetamine, phenylpropanolamine, cyclopentamine, tuaminoheptane, naphazoline, tetrahydrozoline
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Indirectly acting sympathomimetics
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Tetrahydrozoline
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Visine, vasoconstricts and helps clear up red eyes
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