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32 Cards in this Set
- Front
- Back
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botulinum moa
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inhibits release of ACh
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cocaine and TCA moa
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inhibits NE reuptake
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amphetamine moa
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induces NE release
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Reserpine moa
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inhibits packaging (of dopamine) into vesicles (where it would be turned into NE and released from)
cholinergic drug with same moa is vesamicol |
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cholinomimetic for ileus and urinary retention
anticholinesterase for ileus and urinary retention |
bethanechol
neostigmine |
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muscarinic agonist that reduces urgency in mild cystitis and reduces bladder spasms
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oxybutynin and glycopyrrolate
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muscarinic antagonists that are given in peptic ulcer disease
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methscopalamine, pirenzapine, propantheline (also work for urinary incontinence)
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which sympathetic receptor decreases uterine tone
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B2
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antimuscarinic side effects
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dry as a, red as a, blind as a, mad as a, hot as hell.
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which receptors relax renal smooth muscle
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D1
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which receptors modulate transmitter release in the brain and elsewhere
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D2
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which receptors increase gastric acid secretion
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H2
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which receptors do allergy like symptoms
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H1
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which V receptors increase vascular smooth muscle tone?
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V1
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which V receptors do waer permeability in the CT of kids?
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V2
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Unwanted side effects of antimuscarinics and the conditions they exacerbate
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mydriasis - angle closure glaucome of elderly
urinary retention - men with BPH hyperthermia - infants |
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hexamethonium effect on reflexes
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ganglionic blocker prevents vagal reflex response to changes in blood pressure (ie prevents reflex bradycardia caused by NE)
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effect of isoproterenol
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slight increase systolic BP immediately followed by decreased systolic BP (B1 without a1) due to the major drop in mean BP and diastolic BP (B2) in the absence of alpha.
increased heart rate (B1) |
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effect of epi on BP
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increased systolic (a1 and B1)
no change in mean BP decreased diastolic (B2) increased HR (B1) |
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effect of NE on BP
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increased systolic (B1)
increased mean BP increased diatolic (a1) reflex bradycardia follow increased mean BP (can be blocked by hexamethonium) |
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sympathoplegic good for hypertension in renal disease?
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clonidine and aMD - no decrease in renal blood flow.
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mirtazapine SE
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sedation, increased cholesterol and appetite.
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epi effects before a-block
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increased all pressures
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phenylephrine before a-block
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increased all pressures
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epi after a-block (phentolamine)
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decreased all pressures
B2 unopposed |
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phenylephrine after a-block (phentolamine)
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no change in BPs b/c phenylephrine is only alpha agonist ( no beta stim)
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ethylene glycol toxicity
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nephrotoxicity due to oxalic acid (oxalate stones)
acidosis |
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methanol toxicity
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severe acidosis
retinal damage |
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first line for HTN in Pregnancy
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hydralazine and methyldopa
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what increases toxicity of class 1 antiarrhythmics?
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hypokalemia
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ventricular and digitalis induced arrhythmias, give what?
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Class 1B
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Vfib, and intractable SVT, what to give?
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class IC
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