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54 Cards in this Set

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It blocks the enzyme that converts tyrosine to dopa (tyrosine hydroxylase). Over time it decreases the amount of tranmitter stored in the nerve. It is used extensively in management of pheochromocytoma.
Alpha-methyl-tyrosine
It blocks the vesicular pump into storage vesicles and eventually depletes a nerve of its transmitter. No synthesis or storage of Norepinephrine. Effective in management of high blood pressure and a sedative because it reduces storage of central amines.
Reserpine
This interferes with coupling of action potential to vesicle docking. It does not have an effect on parasympathetic nerves. Potent and orally effective antihypertensive.
guanethidine
An alpha receptor antagonist that doesn't have much of an effect on pre-synaptic receptors.
Prazosin
A beta blocker, blocks interaction of Ne with receptor. A cardioprotective agent that prevents arrhymia and helps treat angina.
Propanolol
A COMT inhibitor, used with schizophrenia.
Pyrogallol
An MAO inhibitor that inhibits breakdown of Ne and Epi.
Pargyline
This blocks the neuronal uptake pump and increases norepinephrine in the synapse. Also has some effects on the peripheral nervous system - like hypertension and arrythmia.
Cocaine
This has selectivity for pre-synaptic Alpha-2 receptors. It reduces the amount of transmitter in hte synapse by acting very much like Norepinephrine feedback. It is a good anti-hypertensive agent. Most of its action is central, can be used as a sedative and to manage withdrawl.
Clonidine
This compound blocks alpha receptors, but not beta receptors.
Phenoxybenzamine (PBZ)
This compound blocks beta responses, but not alpha
Dichloroisoproterenol (DCI)
Agent acts on A1, A2, B1, B2
Epinephrine
Agent acts on A1, A2, B1
Norepinephrine
(does not act on B2)
These agents act only on A1 receptors
Phenylephrine, methoxamine
This agent acts on A2 receptors only
Clonidine
This agent acts on B1 and B2 receptors
Isoproterenol
This agent acts on B1 receptors
Dobutamine
These agents act on B2 receptors
Terbutaline, albuterol, metaproterenol
This is a mixed action sympathomimetic
Ephedrine
This is an indirectly acting sympathomimetic agent
Amphetamine and Tyramine
These agents are antagonists to A1 and A2 receptors
Phenoxybenzamine and phentolamine
This antagonizes A1 receptors
Prazosin
This antagonizes A2 receptors
Yohimbine
These agents antagonize B1 and B2 receptors
Propranolol, timolol, pindolol, nadolol
These agents are antagonists to B1 receptors
Metoprolol, atenolol, alprenolol
This agent is an antagonist to A1 and beta receptors
Labetalol
This drug is not selective for alpha receptors, but is an agonist of both beta receptors, equally
Isoproterenol
This is the only non-selective agonist for adrenal receptors
Epinephrine
This adrenergic agonist is selective for B1 receptors
Dobutamine
These drugs works well as A2 agonists
Alpha methyl dopa and Clonidine
Trade name Levophed
Levarterenol = Norepinephrine
Trade name Adrenalin
Epinephrine
Trade name Isuprel
Isoproterenol
Main type of receptor in skin
A1
Main type of receptor in viscera
A1 (some B2, but way more alpha than beta so isoproterenol doesn't have much effect)
Main type of receptor in Skeletal muscle
B2 - NE causes constriction, isoproterenol causes dilation. Epinephrine effects are dose dependent, biologic levels dilate, high concentrations constrict
Main type of receptor in pulmonary
A1
Type of receptors in coronary arteries
Beta, but mainly they are under autoregualtion
Decreased PVR, increased systolic BP
Isoproterenol
increased PVR, increased systolic, diastolic, and mean BP, decreased HR, increased CO
Norepinephrine
Decreased PVR and diastolic, increased systolic, but only under therapeutic levels. HR increases.
Epinephrine
Muscarinic antagonist
Atropine, blocks PNS effects
Main receptor on bronchial smooth muscle
B2 - iso and epi work well to dilate
Main receptor in GI
B2, inhibits tone and motility
Main receptor in Iris
A1, NE and Epi cause mydriasis
This catecholamine can only be administered via IV
Norepinephrine
This drug has a very limited therapeutic value but can be used for hypotension if there's good CO and tissue perfusion.
Norepinephrine
This drug is used a lot and is good with anaphylactic shock and to prolong the action of local anesthetics. Also helps with cardiac arrest and open angle glaucoma
Epinephrine
This drug is used in cases of bronchospasm, cardiac arrest, and heart block
Isoproterenol
The vasoconstricting effects of this drug helps to keep local anesthetic in the system longer
Epinephrine
Why doesn't NE cause tremor and weakness like Isoproterenol and Epinephrine?
Because it doesn't stimulate B2. These drugs all cause fear, anxiety, and restlessness. Also palpitations.
Epinephrine, NE, and isoproterenol should be used with caution in what kinds of patients?
Those with hyperthyroidism (thyroid makes B2 receptors more sensitive), hypertension, and angina pectoris.
Anesthetics and catecholamines do what to the heart?
Sensitize myocardium and create arrythmia
What are two serious side effects of catecholamines?
Cerebral hemorrhage, arrhythmia (particularly with halogenated anesthetics)