Autonomic Pharm 1

Front 1

It blocks the enzyme that converts tyrosine to dopa (tyrosine hydroxylase). Over time it decreases the amount of tranmitter stored in the nerve. It is used extensively in management of pheochromocytoma.

Back 1

Alpha-methyl-tyrosine

Front 2

It blocks the vesicular pump into storage vesicles and eventually depletes a nerve of its transmitter. No synthesis or storage of Norepinephrine. Effective in management of high blood pressure and a sedative because it reduces storage of central amines.

Back 2

Reserpine

Front 3

This interferes with coupling of action potential to vesicle docking. It does not have an effect on parasympathetic nerves. Potent and orally effective antihypertensive.

Back 3

guanethidine

Front 4

An alpha receptor antagonist that doesn't have much of an effect on pre-synaptic receptors.

Back 4

Prazosin

Front 5

A beta blocker, blocks interaction of Ne with receptor. A cardioprotective agent that prevents arrhymia and helps treat angina.

Back 5

Propanolol

Front 6

A COMT inhibitor, used with schizophrenia.

Back 6

Pyrogallol

Front 7

An MAO inhibitor that inhibits breakdown of Ne and Epi.

Back 7

Pargyline

Front 8

This blocks the neuronal uptake pump and increases norepinephrine in the synapse. Also has some effects on the peripheral nervous system - like hypertension and arrythmia.

Back 8

Cocaine

Front 9

This has selectivity for pre-synaptic Alpha-2 receptors. It reduces the amount of transmitter in hte synapse by acting very much like Norepinephrine feedback. It is a good anti-hypertensive agent. Most of its action is central, can be used as a sedative and to manage withdrawl.

Back 9

Clonidine

Front 10

This compound blocks alpha receptors, but not beta receptors.

Back 10

Phenoxybenzamine (PBZ)

Front 11

This compound blocks beta responses, but not alpha

Back 11

Dichloroisoproterenol (DCI)

Front 12

Agent acts on A1, A2, B1, B2

Back 12

Epinephrine

Front 13

Agent acts on A1, A2, B1

Back 13

Norepinephrine
(does not act on B2)

Front 14

These agents act only on A1 receptors

Back 14

Phenylephrine, methoxamine

Front 15

This agent acts on A2 receptors only

Back 15

Clonidine

Front 16

This agent acts on B1 and B2 receptors

Back 16

Isoproterenol

Front 17

This agent acts on B1 receptors

Back 17

Dobutamine

Front 18

These agents act on B2 receptors

Back 18

Terbutaline, albuterol, metaproterenol

Front 19

This is a mixed action sympathomimetic

Back 19

Ephedrine

Front 20

This is an indirectly acting sympathomimetic agent

Back 20

Amphetamine and Tyramine

Front 21

These agents are antagonists to A1 and A2 receptors

Back 21

Phenoxybenzamine and phentolamine

Front 22

This antagonizes A1 receptors

Back 22

Prazosin

Front 23

This antagonizes A2 receptors

Back 23

Yohimbine

Front 24

These agents antagonize B1 and B2 receptors

Back 24

Propranolol, timolol, pindolol, nadolol

Front 25

These agents are antagonists to B1 receptors

Back 25

Metoprolol, atenolol, alprenolol

Front 26

This agent is an antagonist to A1 and beta receptors

Back 26

Labetalol

Front 27

This drug is not selective for alpha receptors, but is an agonist of both beta receptors, equally

Back 27

Isoproterenol

Front 28

This is the only non-selective agonist for adrenal receptors

Back 28

Epinephrine

Front 29

This adrenergic agonist is selective for B1 receptors

Back 29

Dobutamine

Front 30

These drugs works well as A2 agonists

Back 30

Alpha methyl dopa and Clonidine

Front 31

Trade name Levophed

Back 31

Levarterenol = Norepinephrine

Front 32

Trade name Adrenalin

Back 32

Epinephrine

Front 33

Trade name Isuprel

Back 33

Isoproterenol

Front 34

Main type of receptor in skin

Back 34

A1

Front 35

Main type of receptor in viscera

Back 35

A1 (some B2, but way more alpha than beta so isoproterenol doesn't have much effect)

Front 36

Main type of receptor in Skeletal muscle

Back 36

B2 - NE causes constriction, isoproterenol causes dilation. Epinephrine effects are dose dependent, biologic levels dilate, high concentrations constrict

Front 37

Main type of receptor in pulmonary

Back 37

A1

Front 38

Type of receptors in coronary arteries

Back 38

Beta, but mainly they are under autoregualtion

Front 39

Decreased PVR, increased systolic BP

Back 39

Isoproterenol

Front 40

increased PVR, increased systolic, diastolic, and mean BP, decreased HR, increased CO

Back 40

Norepinephrine

Front 41

Decreased PVR and diastolic, increased systolic, but only under therapeutic levels. HR increases.

Back 41

Epinephrine

Front 42

Muscarinic antagonist

Back 42

Atropine, blocks PNS effects

Front 43

Main receptor on bronchial smooth muscle

Back 43

B2 - iso and epi work well to dilate

Front 44

Main receptor in GI

Back 44

B2, inhibits tone and motility

Front 45

Main receptor in Iris

Back 45

A1, NE and Epi cause mydriasis

Front 46

This catecholamine can only be administered via IV

Back 46

Norepinephrine

Front 47

This drug has a very limited therapeutic value but can be used for hypotension if there's good CO and tissue perfusion.

Back 47

Norepinephrine

Front 48

This drug is used a lot and is good with anaphylactic shock and to prolong the action of local anesthetics. Also helps with cardiac arrest and open angle glaucoma

Back 48

Epinephrine

Front 49

This drug is used in cases of bronchospasm, cardiac arrest, and heart block

Back 49

Isoproterenol

Front 50

The vasoconstricting effects of this drug helps to keep local anesthetic in the system longer

Back 50

Epinephrine

Front 51

Why doesn't NE cause tremor and weakness like Isoproterenol and Epinephrine?

Back 51

Because it doesn't stimulate B2. These drugs all cause fear, anxiety, and restlessness. Also palpitations.

Front 52

Epinephrine, NE, and isoproterenol should be used with caution in what kinds of patients?

Back 52

Those with hyperthyroidism (thyroid makes B2 receptors more sensitive), hypertension, and angina pectoris.

Front 53

Anesthetics and catecholamines do what to the heart?

Back 53

Sensitize myocardium and create arrythmia

Front 54

What are two serious side effects of catecholamines?

Back 54

Cerebral hemorrhage, arrhythmia (particularly with halogenated anesthetics)