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10 Cards in this Set
- Front
- Back
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Nicotinic Receptors
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-ACh receptor
-blocked by curare on skeletal muscles -blocked by hexamethonium on ANS ganglion |
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Muscarinic Receptors
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-ACh receptor
-blocked by atropine on cardiac and smooth muscle and glands |
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Alpha-1 Receptors
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-NE receptor
-activation leads to contraction of smooth muscle in blood vessels |
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Alpha-2 Receptors
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-NE receptor
-Found on adrenergic presynaptic membrane -Acts as an autoreceptor for NE to inhibit further release |
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Beta-1 receptors
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-NE receptor
-activation increases heart rate and force of contraction |
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Beta-2 receptor
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-NE receptor
-activation relaxes GI tract smooth muscle and some vascular smooth muscle |
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Neurotransmitters used in ANS
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ACh, NE, ATP/adenosine, NO, Serotonin, Dopamine, GABA
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Termination of NE action in ANS
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1. Re-uptake of NE by active transport (70%) folloed by breakdown with MAO
2. Diffusion of NE from synaptic cleft into capillaries 3. Extra-neuronal uptake of NE followed by MAO beakdown |
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Neurotransmitter used between per-and post-ganglionic cells of ANS
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Acetylcholine
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NT released by adrenal medulla
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NE (20%), Epi(80%)
*only innervated by sympathetic division |
