Autonomic Nervous System L2

Front 1

Nicotinic effects? (3)

Back 1

1. stimulation of autonomic ganglia
2. stimulation of volutary muscles
3. secreation of adrenaline from adrenal medulla

Front 2

3 classes of nicotinic receptors?
what are they?
what do they do?

Back 2

CNS, Muscle, Ganglionic
all ligand gated ion channels
causes depolarisation of postganglionic cell body via influx of Na+

Front 3

Stimulant drugs effecting autonomic ganglia? (3)
clinical use?
effects?

Back 3

nicotine, lobeline, DMPP
experimental tools, no clinical use
effects complex - tachycardia, increased BP and secretions (swaet, saliva etc)

Front 4

Ganglion blocking drugs
3 mechanisms?

Back 4

1. interference of Ach release
2. prolonged depolarisation
3. interferance of postsynaptic action of Ach

Front 5

Interferance of Ach release (3)?
mechanism?

Back 5

1. Mg 2+
2. Botulin toxin - prevents exocytosis of Ach
3. Hemicholinium - inhibits uptake of choline and thus synthesis of Ach

Front 6

Prolonged depolarisation drugs? (2) and mechanism

Back 6

1. Nicotine - initial stimulation, prolonged exposure (depolarisation and inactivation)
2. cholinesterase inhibitors - Ach not broken down, prolonged exposure of Ach, depolarisation & inactivation

Front 7

Interferance of postsynaptic action of Ach, 2 ways? (2 drugs)

Back 7

1. blockade of nicotine receptor
2. blockade of associated ion channels (hexamethonium, trimetaphan)

Front 8

Effects of ganglion blocking drugs?

Back 8

many effects, complex, both branches of ANS blocked
fall in BP due to inhibition of sympathetic tone (vasodilation), postural hypotension (loss of sympathetic vasoconstrictor activity upon standing)

Front 9

Clinical uses of ganglionic block?

Back 9

mainly obsolete due to side effects
trimetaphan (rarely) used in surgery - tilting the table for controlled hypotension to reduce bleeding, emergancy lowering BP,