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28 Cards in this Set

  • Front
  • Back
alpha-1 adrenergic receptors

subtypes
alpha-1A, alpha-1B, and alpha-1D (no C!!!)
the G protein coupling for alpha-1 adrenergic receptors
alphaq/11
PLC/open membrane
Calcium channels
alpha-1 adrenergic receptors

Second messenger pathway
increases the amount of phospholipase C
alpha-1 adrenergic receptors

effector
Protein Kinase C
alpha-2 adrenergic receptors

subtypes
alpha-2A, alpha-2B, and alpha-2C
alpha-2 adrenergic receptors

G protein coupling
alpha 1 (maybe)

inhibits adenylyl cyclase
(also alpaq/11 to PLC)
alpha-2 adrenergic receptors

second messenger pathway
decreases amount of cAMP

(increases PLC, PLD, PLA2)
alpha-2 adrenergic receptor

effector protein
Protein kinase A

(also protein kinase C)
Beta adrenergic receptors

subtypes
beta-1, beta-2, and beta-3
Beta adrenergic receptors

G protein coupling
alpha-S activates

activate adenylyl cyclase
Beta adrenergic receptors

Second messenger pathway
Increases amount of cAMP
Beta adrenergic receptors

Effect protein
protein kinase A
Alpha-1 adrenergic receptors

CONSTRICT:
blood vessels and bronchi
Alpha-1 adrenergic receptors

CONTRACT:
uterus, sphincter, seminal tract, and iris
Alpha-2 adrenergic receptors

CONSTRICT:
blood vessels
Alpha-2 adrenergic receptors

RELAX:
GI smooth muscle
Beta-1 adrenergic receptors

RELAX:
GI smooth muscle
Beta-1 adrenergic receptors mainly work on the:
HEART!!!

increase rate, increase force, increase AV node conduction velocity
Beta-2 adrenergic receptors

DILATE:
blood vessels and bronchi
Beta-2 adrenergic receptors

RELAX:
GI sphincter, uterus, detrusor, seminal tract, and ciliary muscle
Alpha-1 adrenergic receptors mainly act on:
LIVER: glycogenolysis and potassium release

SALIVARY GLAND: potassium release
Alpha-2 adrenergic receptors mainly act on:
PLATELETS: aggregation of platelets
Beta-1 adrenergic receptors mainly act on:
FAT: lipolysis (B3 receptors)

SALIVARY GLAND: amylase secretion
Beta-2 adrenergic receptors mainly act on:
LIVER: glycogenolysis

MAST CELLS: inhibit histamine release
D1 (DA1) and D5 receptors
*postsynaptic receptors distributed in brain and renal vasculature

*activate adenylyl cyclase and increase cAMP
D2 (DA2) receptors
*postsynaptic receptors are located in brain and SM and act through G proteins to inhibit adenylyl cyclase

*presynaptic receptors are found on nerve terminals and increase K+ conductance
D3 receptors
*postsynaptic receptors that are located primarily in the brain

*inhibit adenylyl cylcase
D4 adrenergic receptors
*postsynaptic receptors located in the brain and cardiovascular system

*inhibit adenylyl cyclase