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28 Cards in this Set
- Front
- Back
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alpha-1 adrenergic receptors
subtypes |
alpha-1A, alpha-1B, and alpha-1D (no C!!!)
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the G protein coupling for alpha-1 adrenergic receptors
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alphaq/11
PLC/open membrane Calcium channels |
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alpha-1 adrenergic receptors
Second messenger pathway |
increases the amount of phospholipase C
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alpha-1 adrenergic receptors
effector |
Protein Kinase C
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alpha-2 adrenergic receptors
subtypes |
alpha-2A, alpha-2B, and alpha-2C
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alpha-2 adrenergic receptors
G protein coupling |
alpha 1 (maybe)
inhibits adenylyl cyclase (also alpaq/11 to PLC) |
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alpha-2 adrenergic receptors
second messenger pathway |
decreases amount of cAMP
(increases PLC, PLD, PLA2) |
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alpha-2 adrenergic receptor
effector protein |
Protein kinase A
(also protein kinase C) |
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Beta adrenergic receptors
subtypes |
beta-1, beta-2, and beta-3
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Beta adrenergic receptors
G protein coupling |
alpha-S activates
activate adenylyl cyclase |
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Beta adrenergic receptors
Second messenger pathway |
Increases amount of cAMP
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Beta adrenergic receptors
Effect protein |
protein kinase A
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Alpha-1 adrenergic receptors
CONSTRICT: |
blood vessels and bronchi
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Alpha-1 adrenergic receptors
CONTRACT: |
uterus, sphincter, seminal tract, and iris
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Alpha-2 adrenergic receptors
CONSTRICT: |
blood vessels
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Alpha-2 adrenergic receptors
RELAX: |
GI smooth muscle
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Beta-1 adrenergic receptors
RELAX: |
GI smooth muscle
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Beta-1 adrenergic receptors mainly work on the:
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HEART!!!
increase rate, increase force, increase AV node conduction velocity |
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Beta-2 adrenergic receptors
DILATE: |
blood vessels and bronchi
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Beta-2 adrenergic receptors
RELAX: |
GI sphincter, uterus, detrusor, seminal tract, and ciliary muscle
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Alpha-1 adrenergic receptors mainly act on:
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LIVER: glycogenolysis and potassium release
SALIVARY GLAND: potassium release |
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Alpha-2 adrenergic receptors mainly act on:
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PLATELETS: aggregation of platelets
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Beta-1 adrenergic receptors mainly act on:
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FAT: lipolysis (B3 receptors)
SALIVARY GLAND: amylase secretion |
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Beta-2 adrenergic receptors mainly act on:
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LIVER: glycogenolysis
MAST CELLS: inhibit histamine release |
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D1 (DA1) and D5 receptors
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*postsynaptic receptors distributed in brain and renal vasculature
*activate adenylyl cyclase and increase cAMP |
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D2 (DA2) receptors
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*postsynaptic receptors are located in brain and SM and act through G proteins to inhibit adenylyl cyclase
*presynaptic receptors are found on nerve terminals and increase K+ conductance |
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D3 receptors
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*postsynaptic receptors that are located primarily in the brain
*inhibit adenylyl cylcase |
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D4 adrenergic receptors
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*postsynaptic receptors located in the brain and cardiovascular system
*inhibit adenylyl cyclase |
