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20 Cards in this Set
- Front
- Back
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What is the cholinesterase reactivator?
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Pralidoxime
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What drug has effectiveness that is time dependent in that early treatment is much more successful?
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Pralidoxime
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What clinical manifestation do you see with low doses of Atropine?
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Slight paradoxical bradycardia due to CNS vagal stimulation
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What clinical manifestation do you see with higher doses of atropine
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Antagonization of the peripheral muscarinic receptors at the heart, producing bradycardia
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Who is much more sensitive to atropine?
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Children
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What are the symptoms of atropine poisoning?
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hot dry skin, dilated pupils, and maniacal behavior (red as a beet, hot as a pistol, dry as a bone, mad as a hatter)
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What is the one major difference b/t Scopolamine and atropine
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Scopolamine has CNS depressant effects
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what is a less potent and much shorter acting muscarinic antagonist?
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Tropicamide
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What is tropicamide used to for?
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General ophthalmological exams
(atropine & scopolamines effects are too prolonged) |
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What are synthetic muscarinic antagonists that have few systemic side effects and are applied topically to airway by metered inhaler?
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Ipratropium & Tiotropium
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What are Ipratropium & Tiotropium primarilly used for?
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Chronic obstructive pulmonary disease
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Why are Ipratropium & Tiotropium used to treat COPD?
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They produce bronchodilation w/o reduction of volume or inc. of viscosity of bronchial secretions
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What is a second line drug for treatment of bronchial asthma
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Ipratropium
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Ipratropium appears to be beneficial when combined with other what?
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Bronchodilators
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What asthma treatment has a longer duration of action and can be used once/day?
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Tiotropium
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What CNS acting antimuscarinic drug is used to relieve symptoms of Parkinson's disease?
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Benztropine
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What atropine-like agent is used to treat spasms of the bladder and some neurological disorders producing bladder hyperactivity?
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Oxybutynin
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How is Oxybutynin administered?
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either orally or topically (via catheter)
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How does oxybutynin improve continence?
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decreases tone of bladder smooth muscle
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What are the muscarinic blocking drugs?
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1. Atropine
2. Scopolamine 3. Tropicamide 4. Ipratropium & Tiotropium 5. Benztropine 6. Oxybutynin |
