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67 Cards in this Set
- Front
- Back
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the drug procainamide can cause __?
what test would by abnormal? |
drug induced lupus
anti-histone antibody |
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that does anti-ds DNA show?
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SLE with renal disease
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what does anti-ribonucleoptoein show?
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Sysetemic sclerosis
MCTD - present in 100% |
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what is MCTD
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MCTD
mixed connective tissue disease signs & symptoms similar to SLE, systemic sclerosis, and PM (polymyosis) no renal involvement |
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what is a marker for CREST syndome?
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anticentromere antibodies
sometimes systemic sclerosis (less common) |
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anti-ss-b (la) antibodies
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sjogren's syndrome
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ANA pattern: homogeneous
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drug induced lupus
SLE, RA |
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ANA pattern: rim
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SLE renal involement
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ANA pattern: speckles
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MC
sjogren's systemic sclerosis SLE |
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ANA pattern: nucleolar
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systemic sclerosis
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recuced lung compliance, renal disease, hemolytic anemia, and pericardial effusion?
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SLE
serum ANA with rim pattern (nephritic glomerulonephritis w RBC casts) direct coombs' (warm autoimmune hemolytic anemia) |
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is renal disease a feature of RA?
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NO
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what is band test?
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IF test for immunocomplex deposition along basement membrane in SLE
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what kind of endocarditis do SLE pts get?
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Libman-Sacks endocarditis
(sterile veetations on mitral valve) |
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SLE or systemic sclerosis?
feature: endocarditis |
SLE
Libman Sacks endocarditis sterile vegetations on mitral valve |
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SLE or systemic sclerosis?
feature: restictive lung disease |
SLE & systemic sclerosis
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SLE or systemic sclerosis?
feature: renal failure |
both
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SLE or systemic sclerosis?
feature: FP syphilis serology |
SLE
sue to anti-cardiolipin antibodies that cross-react with beef cardiolipin in test |
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SLE or systemic sclerosis?
feature: dysphagia for solids & liquids |
SS
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systemic sclerosis targets which organ systems?
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SKIN, gi, lungs, kidneys
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Paynaud's phenomenon color pattern? what disease is this common in?
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white --> blue --> red
systemic sclerosis MC initial complaint |
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what is the MCC of death in systemic sclerosis?
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respiratory failure
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what is the MCC of death in SLE?
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infection due to immunosuppression
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other than ANA, which other tests are useful in SS?
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anti-centromere antibody
=CREST mostly but SS, too anti-Scl-70 antibody (topoisomerase I) = 30% |
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SS has what kind of lung disease?
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interstitial lung disease
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what is CREST syndrome?
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C = calcification, centromere antibody
R = paynaud's E = esophageal dysmotility S = sclerodactyly T = telangiectasias |
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what antibodies is present in 50-90% of CREST?
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anticentromere antibodies
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which diseases are LESS common in CREST than SS?
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renal
interstitial lung |
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SLE vs RA?
feature: neutorphil with phagocytosed DNA |
SLE
LE cell |
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SLE vs RA?
feature: neutrophil with phagocytosed immunocomplexes |
RA
ragocytes |
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SLE vs RA?
feature: body cavity effusion |
both
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SLE vs RA?
feature: anti-ds antibodies |
SLE
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SLE vs RA?
feature: cavitating nodules in lungs |
neither:
Caplan's syndrome pneumoconiosis |
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SLE vs RA?
feature: +ANA |
both
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SLE vs RA?
feature: anemia of chronic disease |
both
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SLE vs RA?
feature: destructive joint disease |
RA
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SLE vs RA?
feature: elevated sedimentation rate |
both
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SLE vs RA?
feature: high serum complement leverls |
RA
SLE = lower complement levels |
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SS/CREST vs SLE?
feature: wide-mouthed diverticula |
SS
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SS/CREST vs SLE?
feature: relaxed lower espohageal sphincter |
SS
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SS/CREST vs SLE?
feature: pericardial friction rub |
SLE
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SS/CREST vs SLE?
feature: raynauds |
SS
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SS/CREST vs SLE?
feature: dysphagia for solids and liquids |
SS
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SS/CREST vs SLE?
feature: glomerulonephritis |
both
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SS/CREST vs SLE?
feature: + band test |
SLE
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SS/CREST vs SLE?
feature: unexplained pleural or pericardial effusion |
SLE
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SS/CREST vs SLE?
feature: antoimmune warm hemolytic anemia |
SLE
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anti-topoisomerase and anti-Scl-70?
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SS
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anti-sm and anti-ds DNA
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SLE
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anti-histone
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SLE
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anti-nucleolar
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SS
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anti-glomerular basement membrane
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goodpsture's
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anti-ds DNA
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SLE
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anti-ribonucleoprotein
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MCTD
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anti-JO-1
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PM/DM
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anti-pohospholipid
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SLE
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anti-gliadin
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celiac disease
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anti-mitochondrial
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primary biliary cirrhosis
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anti-microsomal
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hashimoto's thyroiditis
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explain vertial transmission from +SLE mother
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anti-Ro antibodies & IgG anti-SS-A (Ro) antibodies
which have crossed the placenta and attacked the babies conduction system |
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what condition is seen in baby with vertical transmission of Ro from SLE mom?
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complete heart block
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Gottron's patches
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scaly patches (purple papules) over PIP joints
Dermatomyositis |
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heliotrope eyelids
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racoon eyes
Dermatomyositis |
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what lab test is elevated in DM due to atrophy of shoulder mm?
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elevated serum CK
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what are the lab tests in DM/PM?
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1. serum ANA in < 30%
2. elevated serum CK 3. m. bx shows lyphocytic infiltrate |
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what is there a risk of in DM/PM?
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lung cancer
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DM = ?
PM = ? |
DM = dermatomyositis
antibody mediated damage PM = polymyositis t cell mediated damage |
