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67 Cards in this Set

  • Front
  • Back
the drug procainamide can cause __?

what test would by abnormal?
drug induced lupus

anti-histone antibody
that does anti-ds DNA show?
SLE with renal disease
what does anti-ribonucleoptoein show?
Sysetemic sclerosis

MCTD - present in 100%
what is MCTD
MCTD
mixed connective tissue disease

signs & symptoms similar to SLE, systemic sclerosis, and PM (polymyosis)
no renal involvement
what is a marker for CREST syndome?
anticentromere antibodies

sometimes systemic sclerosis
(less common)
anti-ss-b (la) antibodies
sjogren's syndrome
ANA pattern: homogeneous
drug induced lupus
SLE, RA
ANA pattern: rim
SLE renal involement
ANA pattern: speckles
MC
sjogren's
systemic sclerosis
SLE
ANA pattern: nucleolar
systemic sclerosis
recuced lung compliance, renal disease, hemolytic anemia, and pericardial effusion?
SLE

serum ANA with rim pattern
(nephritic glomerulonephritis w RBC casts)

direct coombs'
(warm autoimmune hemolytic anemia)
is renal disease a feature of RA?
NO
what is band test?
IF test for immunocomplex deposition along basement membrane in SLE
what kind of endocarditis do SLE pts get?
Libman-Sacks endocarditis
(sterile veetations on mitral valve)
SLE or systemic sclerosis?
feature: endocarditis
SLE

Libman Sacks endocarditis
sterile vegetations on mitral valve
SLE or systemic sclerosis?
feature: restictive lung disease
SLE & systemic sclerosis
SLE or systemic sclerosis?
feature: renal failure
both
SLE or systemic sclerosis?
feature: FP syphilis serology
SLE
sue to anti-cardiolipin antibodies that cross-react with beef cardiolipin in test
SLE or systemic sclerosis?
feature: dysphagia for solids & liquids
SS
systemic sclerosis targets which organ systems?
SKIN, gi, lungs, kidneys
Paynaud's phenomenon color pattern? what disease is this common in?
white --> blue --> red

systemic sclerosis
MC initial complaint
what is the MCC of death in systemic sclerosis?
respiratory failure
what is the MCC of death in SLE?
infection due to immunosuppression
other than ANA, which other tests are useful in SS?
anti-centromere antibody
=CREST mostly but SS, too

anti-Scl-70 antibody
(topoisomerase I)
= 30%
SS has what kind of lung disease?
interstitial lung disease
what is CREST syndrome?
C = calcification, centromere antibody
R = paynaud's
E = esophageal dysmotility
S = sclerodactyly
T = telangiectasias
what antibodies is present in 50-90% of CREST?
anticentromere antibodies
which diseases are LESS common in CREST than SS?
renal
interstitial lung
SLE vs RA?
feature: neutorphil with phagocytosed DNA
SLE

LE cell
SLE vs RA?
feature: neutrophil with phagocytosed immunocomplexes
RA

ragocytes
SLE vs RA?
feature: body cavity effusion
both
SLE vs RA?
feature: anti-ds antibodies
SLE
SLE vs RA?
feature: cavitating nodules in lungs
neither:
Caplan's syndrome
pneumoconiosis
SLE vs RA?
feature: +ANA
both
SLE vs RA?
feature: anemia of chronic disease
both
SLE vs RA?
feature: destructive joint disease
RA
SLE vs RA?
feature: elevated sedimentation rate
both
SLE vs RA?
feature: high serum complement leverls
RA

SLE = lower complement levels
SS/CREST vs SLE?
feature: wide-mouthed diverticula
SS
SS/CREST vs SLE?
feature: relaxed lower espohageal sphincter
SS
SS/CREST vs SLE?
feature: pericardial friction rub
SLE
SS/CREST vs SLE?
feature: raynauds
SS
SS/CREST vs SLE?
feature: dysphagia for solids and liquids
SS
SS/CREST vs SLE?
feature: glomerulonephritis
both
SS/CREST vs SLE?
feature: + band test
SLE
SS/CREST vs SLE?
feature: unexplained pleural or pericardial effusion
SLE
SS/CREST vs SLE?
feature: antoimmune warm hemolytic anemia
SLE
anti-topoisomerase and anti-Scl-70?
SS
anti-sm and anti-ds DNA
SLE
anti-histone
SLE
anti-nucleolar
SS
anti-glomerular basement membrane
goodpsture's
anti-ds DNA
SLE
anti-ribonucleoprotein
MCTD
anti-JO-1
PM/DM
anti-pohospholipid
SLE
anti-gliadin
celiac disease
anti-mitochondrial
primary biliary cirrhosis
anti-microsomal
hashimoto's thyroiditis
explain vertial transmission from +SLE mother
anti-Ro antibodies & IgG anti-SS-A (Ro) antibodies
which have crossed the placenta and attacked the babies conduction system
what condition is seen in baby with vertical transmission of Ro from SLE mom?
complete heart block
Gottron's patches
scaly patches (purple papules) over PIP joints
Dermatomyositis
heliotrope eyelids
racoon eyes
Dermatomyositis
what lab test is elevated in DM due to atrophy of shoulder mm?
elevated serum CK
what are the lab tests in DM/PM?
1. serum ANA in < 30%
2. elevated serum CK
3. m. bx shows lyphocytic infiltrate
what is there a risk of in DM/PM?
lung cancer
DM = ?
PM = ?
DM = dermatomyositis
antibody mediated damage

PM = polymyositis
t cell mediated damage