Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
10 Cards in this Set
- Front
- Back
|
Anti-dsDNA
|
-Abs to ds-DNA, greater specificity than those to ssDNA
-high specificity for SLE, occasionally in other illnesses, and in normal ppl |
|
|
Anti-histone
|
-most assays do not diff the Abs to the 5 major types of histones
-SLE, drug induced lupus, other autoimmune diseases |
|
|
Anti-ENA
|
typical assays test for Abs to 2 extractable nuclear Ags:
Sm (Smith) RNP (ribonucleoprotein) -High spec for SLE, MCTD, SLE |
|
|
Anti-SS-A/Ro
|
-ribonucleoproteins
-SLE (especially subacute cutaneous lupus), neonatal lupis, Sjogren's syndrome |
|
|
Anti-SS-B/La
|
-ribonucloproteins
-Sjogren's syndrome, SLE, neonatal lupus |
|
|
Anti-centromere
|
-Abs to the centromere/kinetocore region of the chromosome
-Limited scleroderma (CREST syndrome) |
|
|
Anti-Scl 70
|
-Ab to DNA topoisomerase 1
-Diffuse scleroderma |
|
|
Anti-Jo-1
|
-Ab to transfer RNA synthetase
-poly/dermatomyositis, esp in pts w/ interstitial lung disease, Raynaud's phenomenon, cracked skin on hands, arthritis, and resistance to tx |
|
|
Anti-PM-Scl
|
-Abs to a nucleolar granular component
-Polymyositis/scleroderma overlap syndrome |
|
|
Anti-Mi-2
|
-Abs to a nucleolar Ag of unknown fxn
-Dermatomyositis |
