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28 Cards in this Set
- Front
- Back
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H1 antagonists - "antihistamines"
non-selective 1st generation (5) |
ethanolamine
ethylenediamines alkylamines phenothiazines piperazines |
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H1 antagonists - "antihistamines"
peripherally selective2nd generation (4) |
cetirinize
piperadines: astemizole fexofenadine loratidine |
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Clinical uses of antihistamines (3)
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allergies
rhinitis motion sickness and vestibular diseases |
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SE of antihistamines (2)
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sedation
cardiac arrhythmias |
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Unique property of piperadines
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dont cross BBB therefore they do not cause sedation
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What is more effective than antihistamines in treating acute asthma
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epinephrine
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Why is ketoconalzole CI with astemizole?
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astemizole is metabolized by P450; ketoconazole inhibits P450 thus increasing astemizole levels and possible leading to lethal cardiac arrythmias
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H2 antagonists (3)
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cimetidine
rantitidine famotidine |
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Important feature of cimetidine
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inhibits P450 system
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cimetidine uses:
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duodenal and gastric ulcers
ZE syndrome esophagitis |
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Rantidine and Famotidine importance:
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same uses as cimetidine
more potent DO NOT bind P450 |
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Serotonin agonists: (3)
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Triptans
Ergotamine (dihydroergotamine) Ergonovine (Methylergonavine) |
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Triptan use:
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acute treatment of migraine
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Ergotamine (dihydroergotamine)
Ergonovine (Methylergonavine) uses: |
postapartum bleeding
(because they cause uterine contraction which will squeeze spiral arteries) |
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Metyhlsergide class?
uses? (2) |
serotonin antagonist
vascular headache syndromes dumping syndrome |
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ACE inhibitors suffix
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-pril (eg. catopril, enalapril)
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ACE inhibitor uses? (2)
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HTN
CHF |
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ACE inhibitor SE?
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cough
(b/c it inhibits bradykinin degradation) |
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aprotinin class?
use? |
kallikrein inhibitor
acute pancreatitis carcinoid syndrome |
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Whic congenital CV defect are PGs indicated?
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transposition of the great vessels to maintain ductus arteriosus
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Indomethecin use?
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close PDA
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non-selective COX inhibitors
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NSAIDs
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differences between COX-1 and COX-2 inhibition
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COX-1 - GI bleeding and irritation
COX-2 - analgesic and anit-inflammatory |
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Cox-2 inhibitors (2)
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celecoxib
rofecoxib |
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lead poisoining treatment
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Dimercaprol and calcium-sodium EDTA
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dimercaprol uses? (3)
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poisoining:
lead aresenic mercury |
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Penicillamine uses? (4)
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Wilson's disease (Cu)
primary biliary cirrhosis Cystinuria RA |
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deferoxamine uses?
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Irontoxity (usually trasfusion mediated thalassemia)
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