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28 Cards in this Set

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H1 antagonists - "antihistamines"

non-selective 1st generation (5)
ethanolamine
ethylenediamines
alkylamines
phenothiazines
piperazines
H1 antagonists - "antihistamines"

peripherally selective2nd generation (4)
cetirinize
piperadines:
astemizole
fexofenadine
loratidine
Clinical uses of antihistamines (3)
allergies
rhinitis
motion sickness and vestibular diseases
SE of antihistamines (2)
sedation
cardiac arrhythmias
Unique property of piperadines
dont cross BBB therefore they do not cause sedation
What is more effective than antihistamines in treating acute asthma
epinephrine
Why is ketoconalzole CI with astemizole?
astemizole is metabolized by P450; ketoconazole inhibits P450 thus increasing astemizole levels and possible leading to lethal cardiac arrythmias
H2 antagonists (3)
cimetidine
rantitidine
famotidine
Important feature of cimetidine
inhibits P450 system
cimetidine uses:
duodenal and gastric ulcers
ZE syndrome
esophagitis
Rantidine and Famotidine importance:
same uses as cimetidine
more potent
DO NOT bind P450
Serotonin agonists: (3)
Triptans
Ergotamine (dihydroergotamine)
Ergonovine (Methylergonavine)
Triptan use:
acute treatment of migraine
Ergotamine (dihydroergotamine)
Ergonovine (Methylergonavine)
uses:
postapartum bleeding

(because they cause uterine contraction which will squeeze spiral arteries)
Metyhlsergide class?

uses? (2)
serotonin antagonist

vascular headache syndromes
dumping syndrome
ACE inhibitors suffix
-pril (eg. catopril, enalapril)
ACE inhibitor uses? (2)
HTN
CHF
ACE inhibitor SE?
cough

(b/c it inhibits bradykinin degradation)
aprotinin class?

use?
kallikrein inhibitor

acute pancreatitis
carcinoid syndrome
Whic congenital CV defect are PGs indicated?
transposition of the great vessels to maintain ductus arteriosus
Indomethecin use?
close PDA
non-selective COX inhibitors
NSAIDs
differences between COX-1 and COX-2 inhibition
COX-1 - GI bleeding and irritation
COX-2 - analgesic and anit-inflammatory
Cox-2 inhibitors (2)
celecoxib
rofecoxib
lead poisoining treatment
Dimercaprol and calcium-sodium EDTA
dimercaprol uses? (3)
poisoining:
lead
aresenic
mercury
Penicillamine uses? (4)
Wilson's disease (Cu)
primary biliary cirrhosis
Cystinuria
RA
deferoxamine uses?
Irontoxity (usually trasfusion mediated thalassemia)