Augmentation Of Host Defenses

Front 1

Colony Stimulating Factors (CSF)

Reason for use?

Back 1

Accelerate recovery of neutrophils
and
Enhance immune function

Front 2

CSF: Primary use

Back 2

Critical pt.

or

Pt. never on chemo before but predicting neutropenia

Front 3

CSF: Secondary use

Back 3

Subsequent cycles chemo to decrease probability of febrile neutropenia.

Avoid dose reductions or delays of CHEMO if neutropenia occurs.

Front 4

CSF: Use in Febrile Patients

Back 4

NO DATA

Consider in pt. with declining clinical status or ANC < 100

Front 5

SE: Filgrastim (Neupogen)

Back 5

Bone Pain, Fever, Rash,
Inj. site rxn's

Front 6

SE: Sargromastim (Leukine)

Back 6

** Edema, Arthalgias, Rash, Pericarditis **

Fever, Bone pain, Lethargy

Front 7

Dosage: Filgrastim

Back 7

5 mcg/kg/day‚ IV/SC bolus/short IV infusion (15 to 30 minutes)‚ or by continuous SC or continuous IV infusion.

Till ANC 2-3000

Front 8

Dosage: Sargromastim (Leukine)

Back 8

250mcg/m2 (less SE) over 4 hrs
to
500mcg/m2 over 12 hrs

Front 9

Dosage Neulasta (Pegfilgrastim)

Back 9

6mg 1 time shot 24 after chemo

Front 10

CSF: Goal to Cure

Back 10

Add Growth factors to maintain dosage of chemotherapy

Front 11

CSF: Goal to relieve symptoms

Back 11

Reduce dosage of chemotherapy 10 -25% to decr. neutropenia but chemo now less effective.