Atropine

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ATROPINE
Class/ MOA

Back 1

Class:
Anticholinergic agent.
Mechanism of Action:
Parasympatholytic: inhibits action of acetylcholine at postganglionic parasympathetic
neuroeffector sites.
Increases heart rate in life-threatening bradydysrhythmias.

Front 2

ATROPINE
I/CI

Back 2

Indications:
Hemodynamically significant bradycardia.
Asystole.
Drug of choice for organophosphate poisoning.
Bronchospastic pulmonary disorders.
Contraindications:
Tachycardia.
Hypersensitivity.
Unstable cardiovascular status in acute hemorrhage and myocardial ischemia.
Narrow-angle glaucoma.

Front 3

ATROPINE
DI/AR

Back 3

Adverse Reactions:
Headache, dizziness, palpitations, nausea and vomiting.
Tachycardia, dysrhythmias, anticholinergic effects (blurred vision, dry mouth, urinary
retention).
Paradoxical bradycardia when pushed slowly or at low doses.
Flushed, hot dry skin.
Drug Interactions:
Potential adverse effects when administered with digoxin, cholinergics, physostigmine.
Effects enhanced by antihistamines, procainamide, quinidine, antipsychotics,
benzodiazepines and antidepressants.

Front 4

ATROPINE
How supplied

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How Supplied:
Prefilled syringes: 1.0 mg in 10 ml of solution.
Nebulizer: 0.2% (1 mg in 0.5 ml) and 0.5% (2.5 mg in 0.5 ml).
Injection Solution as Sulfate: 0.5mg/ml (1ml); 1mg/ml (1ml);
0.1mg/ml (5ml,10ml); 0.4mg/ml (1ml, 20ml)
Autoinjectors: (See Nerve Agent Antidote)

Front 5

ATROPINE
Doseages

Back 5

Dosage and Administration:
Adult:
- Bradydysrhythymias: 0.5 - 1.0 mg IV every 3-5 minutes as needed to maximum
total dose of 0 .0 4 mg / kg.
- Asystole: 1.0 mg IV push every 3-5 minutes as needed to maximum total dose of
0.04 mg / kg

Pediatric:
- Bradydysrhythmias: 0.02 mg / kg IV / IO (minimum single dose 0.1 mg,
maximum single dose 1.0 mg).
- Asystole: Same as for Bradydysrhythmias: minimum dose 0.1 mg; maximum
dose 0.5 mg for a child and 1.0 mg for adolescent.

Front 6

ATROPINE
DOA/ Special Considerations

Back 6

Duration of Action:
Onset: Immediate.
Peak Effect: Rapid to 1-2 minutes.
Duration: 2-6 hours.
Special Considerations:
Pregnancy Safety: Category C.
Moderate doses dilate pupils.