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14 Cards in this Set
- Front
- Back
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Atropine MOA |
Is an anticholinergic, mostly used for the tx of bradycardia. It antogonises (blocks) muscarinic acteylcholine receptors, causing vagal inhibition resulting in: - Increase in HR - Drying of salivary and bronchial secretions - Bronchodilation - reduced GI motility. |
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Atropine SCOPE |
ICPs |
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Atropine INDICATIONS |
Adults with sinus bradycardia, nodal bradycardia, 1°HB, 2°HB or an undifferentiated narrow complex bradycardia causing significant cardiovascular compromise. Organophosphate poisoning. |
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Atropine CONTRAINDICATIONS |
Known severe Ax. |
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Atropine CAUTIONS |
Myocardial ischaemia. Atropine will increase myocardial oxygen consumption. |
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Atropine IN PREGNANCY/BREASTFEEDING |
Safe. Advise to stop breastfeeding and seek further advice from their LMC or GP. |
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Atropine DOSAGE |
0.6mg for an adult. Repeat as required without a max dose, if bradycardia is responsive to atropine. Repeated and escalating doses are likely to be required for Organophosphate poisoning. |
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Atropine ADMINISTRATION |
Administer undiluted as a rapid IV bolus. Slow administration may result in transient bradycardia. |
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Atropine ADVERSE EFFECTS |
1. Tachycardia 2. Confusion. Particularly in the elderly or those with intellectual impairment. 3. Dry mouth 4. Blurred vision |
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Atropine ONSET |
5-10s |
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Atropine DURATION |
Cardiovascular effects last 15-60mins.
The exocrine and smooth muscle effects last 4-6 hrs. |
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Atropine PREPARATION |
Ampoule containing 0.6mg in 1ml |
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Atropine PHARMACOKINETICS |
Predominantly metabolised in the liver, some excreted in the urine. No significant effects from liver or kidney impairment on acute administration. |
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Atropine INTERACTIONS |
Action of atropine may be potentiated if the pt is taking other drugs with anticholinergic properties, such as phenothiazines, some antihistamines (such as promethazine, but not loratadine), tricyclic antidepressants and anti-parkinsonian medicines... These interactions are rarely clinically significant. |
