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12 Cards in this Set
- Front
- Back
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What do hematopietic growth factors act on?
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-hematopoietic growth factors act on the bone marrow to increase production of RBC
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What is Epoetin used for?
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-anemia of CRF
-HIV clts taking Retrovir -anemia induced by chemo -anemia in clts scheduled for elective surgery |
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What are some SE for Epoetin?
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-HTN 2/2 elevations in HCT
-increased risk for CV event |
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What are some Nrsg interventions for a clt on Epoetin?
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-monitor clts Fe+ levels
-RBC growth dependent on adeqauate quantities of Fe+, folic acid, & vit B12 -monitor clts Hgb & HCT 2x/wk until target range is reached -obtain baseline BP -in CRF, control HTN before tx -do not combine Epoetin c other meds |
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How would the RN evaluate the effectiveness of Epoetin?
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-Hgb levels of 10-12 & HCT of 40%
-increased reticulocyte count |
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What do filgrastin (Neupogen) & pegfilgrastin (Neulasta) do?
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-stimulate the bone marrow to increase production of neutrophils
-decreases the risk of infection in clts c neutropenia |
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What are some SE of filgrastin (Neupogen) & pegfilgrastin (Neulasta)?
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-bone pain
-leukocytosis (decrease dose or stop tx if WBC >50000 or platelets >500000) -->contraindicated in clts sensitive to E. Coli -->should not be combined c other meds |
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What would a RN look for when evaluating filgrastin (Neupogen) & pegfilgrastin (Neulasta) effectiveness?
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-absence of infection
-in chemo for CA tx, an absolute neutrophil count increase to >10000 after chemo induced nadir |
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What does sargramostim (leukine) do?
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-acts on the bone marrow to increase production of WBC (neutrophils, monocytes, macrophages, eosinophils)
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What is sargramostim (leukine) indicated for?
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-facilitates recovery of bone marrow after bone marrow transplant
-used in tx of failed bone marrow transplant |
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What are the SE of sargramostim (leukine)?
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-diarrhea
-weakness -rash -bone pain -leukocytosis -thrombocytosis -->reduce tx if WBC >50000; neutrophils >20000; platelets >500000 -->contraindicated in clt allergic to yeast products; use cautiously in clts c heart disease, hypoxia, peripheral edema, pleural & pericardial effusion |
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How would the RN evaulate the effectiveness of sargramostim (leukine)?
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-clt has absence of infection
-WBC & differential c/in normal ranges |
