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3 Cards in this Set
- Front
- Back
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What initiates Atheroscleroticprocess ? |
LDL with cholesterol accumulate in intimaas a consequence of endothelial dysfunction A•dysfunctionalendothelium express vascular cell adhesion molecule-1(VCAM-1) thatenables monocytes toattach to the endothelial cell surface, cross the endothelium and penetrate theintima of the blood vessel• •Monocytesthen differentiate into macrophages thatexpress scavengerreceptor-A (SR-A) |
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What do SR-a take up? |
•modifiedform of LDL (oxidised LDL) and the massive accumulation transformsmacrophages into cholesterol-laden foam cells •Macrophagefoam cells constitute the atheroma core ofthe atherosclerotic plaque |
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•Threepredisposing situations that may result in thrombus formation |
Virchow’striad •Changesin the intimal surface of the vessel•Changesin pattern of blood flow •Changesin blood constituents – if smoker. |
