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44 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Shigella Flexneri & Salmonella Typhimurium |
Hijacks the rafts |
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Plasma Membrane Blebs |
Detachment of plasma membrane and underlying actin filaments |
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Malaria |
Treatment is chloroquine; Lysosomes
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Dysfunction Lysosomes (General) |
Lysosomal Storage Disease; affects the hydrolytic enzyme or cofactor |
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D/o of Spingolipid Degradation |
Gauchers Dse Tay Sachs Dse Sandhoff Dse Krabbe Dse Niemann-Pick Dse A, B |
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Gauchers Dse |
Protein deficiency: Glucocerebrosidase Accumulation of Glucosyceramide |
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Tay Sachs |
Protein: B- hexosaminidase, a-subunit GM2 Ganglioside |
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Sandhoff Dse |
B- Hexosaminidase, B-subunit GM2 Ganglioside, Oligosaccharides |
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Krabbe Dse |
Galactosylceramidase Gal-ceramide,gal-sphingosine |
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Neiman-Pick Dse A, B |
Sphingomyelinase Sphigomyelin |
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D/o of Glycoprotein Degradation |
Aspartylglycosaminuria a-mannosidosis |
Aspartylglycosaminidase N-linked oligosaccharides |
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a-Mannosidosis |
a-mannosidosis a-mannosidosis |
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D/o of Glycosaminoglycan Degradation |
Hurler syndrome (MPS I) hunter syndrome (MPS II) Maroteaux- Lamy Syndrome (MPS IV) |
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D/o of Single Enzyme Deficiency |
Pompe Dse (glycogenosis II) Wolman Dse (familial Xanthomatosis) Canavan Dse (aspatoacylase Deficiency) |
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D/o of Lysosomal Biogenesis |
I-cell Dse, mucolipidosis II |
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D/o of Lysosomal Membrane |
Danon Dse Cystinosis |
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Danon Dse |
LAMP2 presence of autophagic vacuoles |
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Cystinosis |
Cystinosin Cystine |
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1. Dse/s caused by malfunction of proteasome-mediated degradation
2. Overexpression of proteins causing acceleration of degradtion |
1. Angelman Syndrome Alzheimers Dse
2. Human Papillomavirus |
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Inability of rER to export posttranslationally modified proteins to Golgi |
a1-antittrypsin Deficiency Result: EMPHYSEMA & Liver Damage
A1-antitrypsin inhibits Elastase (Proteasome) from breaking down Elastin. Elastin gives elasticity to lungs. One damaged, this will cause permanent elargement of airspaces. |
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Mitochondrial Defects |
MERRF -MYOCLONIC EPILEPSY RED RAGGED FIBERS- muscle weakness, ataxia, seizures and cardiac and respi failure Mutation of mitochondrial dna gene encoding tRNA for Lysine. Affects ATP production |
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Nonfunctional Peroxisomes; Faulty peroxisomal targeting signals or receptor |
Zellweger Syndrome |
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Dse: Hijacking of actin polymerization machinery. Attacks host phagosome |
Listeriosis |
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Affected in Inherited genetic dse |
Nucleus |
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Werner syndrome (premature aging dse) |
Nucleolus |
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Malfunctions of cell cycle leading to camcerogenesis |
Nucleolus |
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Cystic fibrosis |
Plasma membrane |
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Instestinal malabsorption syndrome |
Plasma membrane |
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Lactose intolerance |
Plasma membrane |
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Pseudoachondroplasia |
rER |
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Calcium phosphate dihydrate crystal doposition dse |
rER |
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Hepatic endoplasmic reticular storage dse |
sER |
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I-cell dse |
Golgi |
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Polycystic kidney dse |
Golgi |
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Lewy bodies of PD |
Secretory vesicles |
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Proinsulin diabetes |
Secretory vesicles |
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MERFF MELAS KEARNS-SAYRE SYNDROME LEBER'S HEREDITARY OPTIC ATROPHY |
Mitochondria |
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M-6-P receptor deficiency |
Endosomes |
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LSD |
Lysosomes |
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Zelwegger Syndrome |
Peroxisomes |
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Alzheimers dse Diamond blackfan anemia |
Ribosomes |
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Accumulation of misfolded proteins in cytoplasm: PD, ALZHEIMERS DSE, ANGELMAN SYNDROME, INCLUSION BODY MYOPATHIES |
Proteasomes |
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Glycogen storage dse |
Glycogen |
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GAUCHERS NEIMANN PICK LIVER CIRRHOSIS |
Lipid droplets |
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