Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
20 Cards in this Set
- Front
- Back
|
What are the four functions of NSAIDS?
|
analgesic, antipyretic, antiinflammatory, antiplatelet
|
|
|
How was aspirin discovered?
|
Willowbark tea reduced fever
|
|
|
Where is ASA absorbed?
|
In the stomach bc its a weak acid, binds to plasma proteins
|
|
|
How does aspirin inhibit prostaglandin metabolism?
|
It irreversibly acetylates and inhibits COX1 and COX2
|
|
|
Why shouldn't you treat children with ASA for treatment for fever?
|
Risk of Reye's Sydrome
|
|
|
How does ASA act as an analgesic?
|
Reduces PG production around peripheral pain receptors
|
|
|
How does ASA act as an antiinflammatory?
|
Decreases PG production, and decreases immune cell migration and activity
|
|
|
How does ASA act as an anti-clotting durg?
|
Irreversibly decreases platelet aggregation by decreases TXA2
|
|
|
Dose of ASA for headache?
|
650 mg/dose
|
|
|
Dose of ASA for RA?
|
4-6 g/day
|
|
|
Lethal dose of ASA in children?
|
4g/day (12 regular ASA)
|
|
|
Lethal dose of ASA in adults?
|
20g/day (50-60 tablets)
|
|
|
What are the most common ASA SE?
|
GI: salicylic acid is a direct irritant, it decreases mucous production and HCO3 production in the intestinal mucosa. Misopristol is a synthetic PGE2 which can improve these effects, but is an abortifacient
|
|
|
ASA SE?
|
GI, Tinnitus, decreased kidney perfusion, renal failure, decreases efficacy of anti-HTN and diuretics, bronchospasms, inhibition of labor
|
|
|
How is acetominophen different from ASA/NSAIDS?
|
No anti-inflammatory or anti-platelet effects, OD can cause irreversible liver damage, prevented by N-acetyl cysteine.
|
|
|
How are NSAIDS different from ASA in mech of axn?
|
NSAIDS are reversible COX inhibitors
|
|
|
Uses for Indomethacin?
|
V. potent COX inhibitor, closes patent ductus arteriosus, can cause aplastic anemia
|
|
|
What are the Cox-2 inhibitors?
|
Celecoxib and Rofecoxib
|
|
|
Use for glucosamine?
|
cartilage management and synthesis
|
|
|
Use for chondroitin sulfate?
|
predominant component in cartilage
|
