• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/48

Click to flip

48 Cards in this Set

  • Front
  • Back
What are ANTIFUNGALS?
Target for destruction with meds: Inhibit synthesis of DNA & RNA, inhibit mitosis
Antifungal Medications
Polyenes-Amphotericin B (Fungazone)

Azole-Fluconazole (Diflucan)
What are the interactions/Precautions for Amphotericin B (Fungazone)?
Route: IV
What are the side effects for Amphotericin B (Fungazone)?
Interactions/Precautions: Highly toxic solution; binds to tissue rather than blood, thereby increasing tissue damage; long half-life because not excreted well; fat soluble; use caution when used with K+ depleting diuretics & digitalis

IV only and used only in the most serious and severe fungal infections Serious kidney damage possible side effect.
What is the route for Amphotericin B (Fungazone)?
SE: renal damage, fever, HA, N/V, anemia, F&E imbalance, nephrotoxicity, hypokalemia
What are examples of Azole?
Fluconazole (Diflucan), Nystantin (Mycostatin),
Clotrimazole (Gyne-Lotrimin), Miconazole (Monistat),
Ketoconazole (Nizoral)
What are the interactions/Precautions for Azole?
Interactions/Precautions: do not give within 2 hours of antacids, hepatotoxicity, depends on stomach acidity for proper absorption, may inhibit testosterone & cortisol,
raise blood concentration of certain meds & lower others

Has an 8 hour half life:
What are the side effects for Azole?
SE: N/V/D, dizziness, nervousness, HA, rashes, puritis thrombocytopenia, allergic reaction, CNS effects
What is the route for Azole?
Route: PO & Topical

Fluconazole(IV or orally)
What are the interactions/Precautions for Fluorinated Pyrimidine?
Interactions/Precautions: use caution with renal damage; may have to use hemodialysis to remove drug from system; caution with bone marrow depression.
What are the side effects of Fluorinated Pyrimidine?
SE: N/V/D, anemia, thrombocytopenia, hepatotoxicity, bruising
What is the route for Fluorinated Pyrimidine?
Route: PO
Drugs for destroying dermatophytic infection?
Griseofulvin (Fulvicin),

Tolnaftate (Tinactin)
What is the route for Griseofulvin (Fulvicin),Tolnaftate (Tinactin)?
Route: PO
What are the side effects for Griseofulvin (Fulvicin),Tolnaftate (Tinactin)?
SE: HA, GI problems, neuritis, allergies, hepatotoxicity
What are the Interactions/Precautions for Griseofulvin (Fulvicin),Tolnaftate (Tinactin)?
Interactions/Precautions: long therapy, caution with oral contraceptives & warfarin

Dermatophytic infection=Bacterial Skin infection Warfarin (Coumadin)—blood thinner
Inform patients of the importance to complete treatment as prescribed to avoid relapse.
What are ANTIVIRALS?
“Avirs” - Protease inhibitors
What are examples of antivirals?
Indinavir (Crixivan), Ritonavir (Norvir), Squinavir (Invirase)
What are protease inhibitors?
Protease Inhibitor=Antiviral Drug(s) used against HIV; interupts HIV replication by binding and blocking HIV protease; inhibits viral protease.
What is the route for protease inhibitors?
Route: PO
What are the side effects of protease inhibitors?
SE: kidney stones, abdominal pain, N/V/D, HA, weakness, and altered taste
What are the Interactions/Precautions of protease inhibitors?
Interactions/Precautions: caution liver damage, hepatotoxicity
What are the uses of Azole?
First PO antifungal. It is effective for systemic fungal infections. Can be used for athletes foot or systemic infections
Why is it important to correctly calculate the dosage of antivirals?
Antiviral drugs need to have the dosage checked closely because the window of effectiveness is very small. If the dose is to low they will be ineffective and if the dose is to high they will be toxic.
What are examples of “ine’s” - Reverse Transcriptase Inhibitors?
Didanosine (DLL, Videx), Lamivudine (3TC, Epivir)
Stavudine (D4T, Zerit), Zalcitabine (ddC, Hivid)
Zidovudine (AZT, Retrovir)
What are the side effects of Reverse Transcriptase Inhibitors?
SE: blood disorders, HA, insomnia, muscle pain, N/V, ataxia, fatigue, nystagmus
What are the Interactions/Precautions of Reverse Transcriptase Inhibitors?
Interactions/Precautions: neurotoxicity, caution with liver damage & bone marrow depression
What is the route for Reverse Transcriptase Inhibitors?
Route: PO
What are uses for Reverse Transcriptase Inhibitors?
Pregnant women + for HIV can take AZT to decrease the risk of transmission to the infant.

These medication slow down the progression of HIV infection.

Reverse T.I.=are antiretroviral drugs used to treat HIV, infection, tumors, and cancer. They interfere with the conversion of RNA to DNA (this is what HIV causes); RT is an enzyme.
What are examples of Non-nucleoside Reverse Transcriptase Inhibitors?
Neverapine (Viramune), Delaviradine (Rescriptor)
What are the side effects of Non-nucleoside Reverse Transcriptase Inhibitors?
SE: N/V/D, fatigue, HA, rashes, stomach pain, mouth ulcers
What are the Interactions/Precautions of Non-nucleoside Reverse Transcriptase Inhibitors?
Interactions/Precautions: must be used in combo therapy due to resistance, hepatotoxic, caution when used with meds & antibiotics
What is the route for Non-nucleoside Reverse Transcriptase Inhibitors?
Route: PO
Why is it important to correctly calculate the dosage of antivirals?
Antiviral drugs need to have the dosage checked closely because the window of effectiveness is very small. If the dose is to low they will be ineffective and if the dose is to high they will be toxic.
What are examples of “ine’s” - Reverse Transcriptase Inhibitors?
Didanosine (DLL, Videx), Lamivudine (3TC, Epivir)
Stavudine (D4T, Zerit), Zalcitabine (ddC, Hivid)
Zidovudine (AZT, Retrovir)
What are the side effects of Reverse Transcriptase Inhibitors?
SE: blood disorders, HA, insomnia, muscle pain, N/V, ataxia, fatigue, nystagmus
What are the Interactions/Precautions of Reverse Transcriptase Inhibitors?
Interactions/Precautions: neurotoxicity, caution with liver damage & bone marrow depression
What is the route for Reverse Transcriptase Inhibitors?
Route: PO
What are uses for Reverse Transcriptase Inhibitors?
Pregnant women + for HIV can take AZT to decrease the risk of transmission to the infant.

These medication slow down the progression of HIV infection.

Reverse T.I.=are antiretroviral drugs used to treat HIV, infection, tumors, and cancer. They interfere with the conversion of RNA to DNA (this is what HIV causes); RT is an enzyme.
What are examples of Non-nucleoside Reverse Transcriptase Inhibitors?
Neverapine (Viramune), Delaviradine (Rescriptor)
What are the side effects of Non-nucleoside Reverse Transcriptase Inhibitors?
SE: N/V/D, fatigue, HA, rashes, stomach pain, mouth ulcers
What are the Interactions/Precautions of Non-nucleoside Reverse Transcriptase Inhibitors?
Interactions/Precautions: must be used in combo therapy due to resistance, hepatotoxic, caution when used with meds & antibiotics
What is the route for Non-nucleoside Reverse Transcriptase Inhibitors?
Route: PO
What are uses of Non-nucleoside Reverse Transcriptase Inhibitors?
Used to slow progression of HIV. Is the 3rd class of HIV meds; blocks reverse transcriptase in a different way; but results are the same—viral suppression.
What are uses of Acyclovir (Zovirax), Ribavirin* (Virazole), Interferons?
Used for Herpes treatment.
What are side effects of Acyclovir (Zovirax), Ribavirin* (Virazole), Interferons?
SE: coma, confusion, N/V/D, phlebitis, seizures, tremor, dizziness, CNS effects, slurred speech, anorexia, constipation, dry mouth, HA, fatigue, blood dyscrasias, skin rashes
What are Interactions/Precautions of Acyclovir (Zovirax), Ribavirin* (Virazole), Interferons?
Interactions/Precautions: nephrotoxic, hepatotoxic, neurotoxic, cardiopulmonary toxicity, caution with epileptics or Parkinsonism, caution with thyroid dysfunction, DM, cardiac problems
What is the route of Acyclovir (Zovirax), Ribavirin* (Virazole), Interferons?
Route: PO, IV, IM, SQ, inhalation