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52 Cards in this Set
- Front
- Back
What are injectable general anesthetics used for?
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Induction for intubation and maintenance on gas. Induction and maintenance by repeated injection.
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What are three classes of injectable general anesthetics?
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Cyclohexamines, Substituted phenols, barbituates.
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What's a disadvantage with using cyclohexamines?
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Induce seizures in dogs and horses.
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What type of action do cyclohexamines have?
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Cause dissociative anesthesia or catalepsy. Selective CNS stimulation, disruption of nerve pathways in brain. Perception & awareness is scrambled.
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Do cyclohexamines cause CNS stimulation or depression?
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Stimulation
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What are some characteristics of cyclohexamines?
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Exaggerated reflexes, presistent laryngeal reflexes, sensitive to light,sound&touch, increased muscle tone, apneustic respiration, hypersalivation, tachycardia, eyes stay open, pupil central & dilated.
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What is apneustic respiration?
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Breath holding after inspiration; quick expiratory phase.
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What type of analgesia do cyclohexamines provide?
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Good skin & limb analgesia, but poor visceral.
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What are some contraindications for cyclohexamines?
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Dogs or horses w/out tranq, seizure disorder or history, renal dz or blockage, hepatic disease in dogs, procedures involving CNS.
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Do cyclohexamines cause tachycardia and/or increased blood pressure?
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Yes
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What should you avoid doing to a patient when using cyclohexamines?
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Stimulate them, they're sensitive to light, sound & touch.
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Why is it difficult to determmine anesthetic depth when using cyclohexamines?
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The animals reflexes are exaggerated.
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What do you need to be aware of during recovery when using cyclohexamines?
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Avoid stimulation, hallucinatory behavior possible, monitor closely to prevent self-injury.
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What's a symptoms of cyclohexamine overdose?
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Seizures.
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What are 3 types of cyclohexamines?
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Ketamine, Tiletamine, TKX
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What's the most commonly used cyclohexamine?
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Ketamine
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How do you administer ketamine?
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IV only in dogs. IV in cats, possible IM or orally
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What do you need to be careful about when administering ketamine.
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Give the correct dose. IM dose given IV can lead to serious overdose and/or death.
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How is ketamine eliminated from the body?
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Renal (kidney) in cats.
Hepatic (liver) in dogs. |
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What other type of drug is commonly used with ketamine?
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Acepromazine, diazepam, xylazine.
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What is always given with tiletamine?
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Zolazepam (Telazol)
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What form does tiletamine come in?
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It's a powder.
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Does Tiletamine have a long or short shelf life?
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Short, 4 day room temp, 14 day refrigerated.
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How is Tiletamine eliminated?
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Hepatic metabolism & renal excretion.
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What's significant about recovery from tiletamine?
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It may be long & difficult in some animals.
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What is in TKX?
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Telazol/xylazine/ketamine.
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Are cyclohexamines controlled drugs?
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Yes
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What's an example of a substitued phenol?
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Propofol
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How is propofol given?
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IV only. IV drip, or injections every 3-5 mns for maintenance.
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What are some characteristics of propofol.
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Can support bacterial growth, 6 hr ref. shelf life, slow injection, milky oil-in-water emulsion.
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Is the recovery from propofol short of fast?
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Very fast, thru redistribution & metabolism.
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What are 4 reasons for using barbiturates?
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Induction, maintenance, anticonvulsant, euthanasia.
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Are substituted phenols controlled drugs?
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No
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What should you do with barbiturates after you've reconstituted them?
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Refrigerate. Discard if cloudiness or crystallization occurs.
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Are barbiturates a good analgesia?
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No
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How do barbiturates work?
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They cause dose dependant CNS depression. Sedation-anesthesia-coma-death.
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How are barbiturates elimated from the body?
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First by redistrubtion to fat, but repeated doses saturate the fat-cleared by liver metabolism-prolonged recovery.
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What may cause higher percentages of barbiturates in the animals blood?
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Animal is acidotic (shock, renal failure), plasma protein is low.
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What route are barbiturates given?
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IV only
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How do you administer barbiturates?
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Titrate to effect.
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What does titrate mean?
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Give 1/2 of dose, then 1/2 of remainder and so on.
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What can happen if barbiturates are not administered IV?
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Tissue necrosis and sloughing.
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What should you do if barbiturates are administered perivascularly?
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Inject sterile saline SQ in site.
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What are some common side effects when using barbiturates?
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Post-induction apnea, transient post-induction arrhythmias, sensitize heart to arrhythmic effect of epinephrine.
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What are some contraindications to barbiturates?
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Cardiovascular or resp. dz, acidosis, CNS depression, thin, or in poor nutritional condition, sighthounds, fearful or agitated animals, geriatrics, neonates, c-sections.
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What are 2 types of barbiturates?
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Thiopental, Pentobarbital.
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Are barbiturates contolled drugs?
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Yes
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Is thiopental ultrashort or intermediate acting?
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Ultrashort.
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Which is more commonly used thiopental or pentobarbital?
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Thiopental.
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Is pentobarbital ultrashort or intermediate acting?
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Intermediate
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When would you use pentobarbital?
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When you have a seizuring animal & diazepam is ineffective.
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Is pentobarbital used for surgery?
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No longer very common.
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