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7 Cards in this Set

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criteria for classification of RA
1. Morning stiffness lasting for at least 1 hr.
2. Simultaneous arthritis of 3 or more jts
4. Arthritis of hand jts
5. Symetrical Arthritis
6. Abnormal serum rhematoid factor
7. X-ray changes typical of RA on PA hand and wrist X-rays

4 of 7 must be present for at least 6 weeks
Triad of Felty's syndrome
Seropositive Rhematoid Arthritis
Splenomegaly
Granulocytopenia
Limitations of NSAIDS for RA
often ineffective in severe cases

does not prevent damage

does not alter disease course
Corticosteroid
Limited time frame due to severe toxicity

Repeat injections ill advised in same joint w/in 3 mo.

Does not alter disease course
DMARD
may not prevent damage despite apparent clinical control

May not have lasting efficacy

May not be tolerated due to toxicity

Delayed onset of action
proinflammatory cytokines
TNF alfa
IL-1
Anti-inflammatory cytokines
IL-1ra
sIL-1R
sTNFR
IL-10
IL-4
IL-11