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Arthritis

by mtimmerman12, May 2006

Subjects: ms

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	criteria for classification of RA	1. Morning stiffness lasting for at least 1 hr. 2. Simultaneous arthritis of 3 or more jts 4. Arthritis of hand jts 5. Symetrical Arthritis 6. Abnormal serum rhematoid factor 7. X-ray changes typical of RA on PA hand and wrist X-rays 4 of 7 must be present for at least 6 weeks
	Triad of Felty's syndrome	Seropositive Rhematoid Arthritis Splenomegaly Granulocytopenia
	Limitations of NSAIDS for RA	often ineffective in severe cases does not prevent damage does not alter disease course
	Corticosteroid	Limited time frame due to severe toxicity Repeat injections ill advised in same joint w/in 3 mo. Does not alter disease course
	DMARD	may not prevent damage despite apparent clinical control May not have lasting efficacy May not be tolerated due to toxicity Delayed onset of action
	proinflammatory cytokines	TNF alfa IL-1
	Anti-inflammatory cytokines	IL-1ra sIL-1R sTNFR IL-10 IL-4 IL-11

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