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7 Cards in this Set
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criteria for classification of RA
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1. Morning stiffness lasting for at least 1 hr.
2. Simultaneous arthritis of 3 or more jts 4. Arthritis of hand jts 5. Symetrical Arthritis 6. Abnormal serum rhematoid factor 7. X-ray changes typical of RA on PA hand and wrist X-rays 4 of 7 must be present for at least 6 weeks |
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Triad of Felty's syndrome
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Seropositive Rhematoid Arthritis
Splenomegaly Granulocytopenia |
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Limitations of NSAIDS for RA
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often ineffective in severe cases
does not prevent damage does not alter disease course |
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Corticosteroid
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Limited time frame due to severe toxicity
Repeat injections ill advised in same joint w/in 3 mo. Does not alter disease course |
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DMARD
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may not prevent damage despite apparent clinical control
May not have lasting efficacy May not be tolerated due to toxicity Delayed onset of action |
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proinflammatory cytokines
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TNF alfa
IL-1 |
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Anti-inflammatory cytokines
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IL-1ra
sIL-1R sTNFR IL-10 IL-4 IL-11 |
