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30 Cards in this Set
- Front
- Back
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What are the drug recommendation for osteoarthritis?
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1. Mild to moderate: paracetamol
2. Moderate to severe: NSAID or NSAID / Cox-2 with GI prophylaxis in high risk pt |
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What are the caution of drug use in osteoarthritis?
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Avoid NSAID and Cox-2 in pt with co-morbidities
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What are the drug Tx for acute gouty arthritis?
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1. NSAID
2. Selective COX-2 inhibitors 3. Corticosteroids 4. Colchicine |
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In drug Tx for acute gouty arhtirits, give different types of steroid in according with different type of administration
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Intra-articular : triamcinolone acetonide
Intramuscular: triamcinolone actonide Oral: prednisolone IV : methylprednisolone |
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Side effect of colchicine in treating acute gouty arthritis?
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Diarrhoea
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What are the 2 broad division of inflmmatory arthritis?
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1. rheumatoid arthritis
2. spondyloarthropathy |
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What does rheumatoid arthritis consist of?
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1. sero +ve RA
2. sero -ve RA |
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What does spondyloarthropathy consist of?
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1. ankylosing spondylitis
2. psoriatic arthritis 3. reactive arthritis 4. inflammatory disease arthritis |
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What is the hallmark of ankylosing spondylitis?
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Enthesitis
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What does enthesitis in ankylosing spondylitis affect?
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1. cartilaginous joint
2. capsules and intracapsular ligament of large synovial joints and apophyseal joints 3. tendon attachement sites |
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What is the hall mark imaging in ankylosing spondyloarthropathy? and other feature?
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Hallmark: sacroiliitis in XR
Other feature: bamboo spine |
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What causes spinal immobility in ankylosing spondyloarthropathy?
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New bone formation
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What is the nail presentation in psoriatic arthritis?
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Nail dystrophy (onycholysis and ridging)
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Give 3 skin manifestation of reactive arthritis
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1. keratoderma blennorrhagica
2. circinate balanitis 3. oral ulcer |
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What happen before arthritis in reactive arthritis?
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Conjunctivitis
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In chronic reactive arthritis, what might develope?
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Uveitis
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Give 2 form of reactive arthritis
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Postenteric reactive arthritis
Postchlamydial reactive arthritis |
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Sex preference of the 2 form or reactive arthritis
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Postenteric reactive arthritis: equal in men and women
Postchlamydial reactive arthritis: men |
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How to differentiate the 2 forms of reactive arthritis on the basis of diarrhoea?
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Prolonged diarrhoea in postenteric reactive arthritis
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How long will reactive arthritis resolve?
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Usually within 6 months. Some will develop chronic arthritis
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What is the onset of arthritis with relation to diarrhea in reactive arthritis?
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Arthritis happen 2 weeks after diarrhoea
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Symmetrical polyarthritis is.....
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rheumatoid arthritis
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Drugs used in rheumatoid arthritis and their function
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Symptom relief:
1. NSAID 2. analgesics 3. glucocorticoid Preven joint damage and relieve symptoms: 1. disease modifying anti-rheumatic (DMARs) 2. Biologics |
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Give 4 approved DMARs
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1. methotrexate
2. sulfasalazine 3. leflunomide 4. hydroxychloroquine |
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Give 5 classes of biologics for rheumatoid arthritis
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1. anti - TNF a
2. IL 1 antagonist 3. IL-6 antagonist 4. Anti -B cell therapy (Rituximab) 5. selective modulation of co-stimulation activation |
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Give 2 other types of lupus other than SLE
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1. discoid lupus (affect only skin)
2. drug-induced lupus (uncommon) |
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Pt at risk of SLE
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1. young male
2. Asian / African Americans 3. +ve family history |
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What is the SLE criteria?
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dopamine rash
D=Discoud lupus O=oral ulcers P=photosensitivity A=arthritis M=malar rash I=immunologic criteria N=neurologic changes E=incr. ESR (tho not a criteria) R=renal dz A=ANA+ S-serositis (pleurisy, pericarditis) H-ematologic dz |
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What is ANA?
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Double strand DNA
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Additional feature of SLE
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1. vasculitis
2. Raynaud's phenomenon 3. scarring alopecia |
