Arcadia Pharmacology Final (Anti-Viral)

Front 1

Define Virus

Back 1

an obligate intracellular parasite

Front 2

why is viral therapy difficult?

Back 2

bc the sxs appear late when virus particles have replicated and only a few groups respond to antiviral drugs

Front 3

Viral RTI for which txs exist include: influenza types __________.

Back 3

A, B, & RSV

Front 4

_________ are employed when pts are allergic to vaccine or if outbreak is due to immunologic variant

Back 4

antiviral agents

Front 5

What are the 3 types of antivirals for RVI?

Back 5

neuramindase inhibitors
viral uncoating inhibitors
ribavirin

Front 6

amantidine and rimantidine do what?

Back 6

viral uncoating inhibitors (antivirals for RVI)

Front 7

oseltamivir and zanamivir (tamiflu, relenza) do?

Back 7

neuramindase inhbitors (NI) (antivirals for RVI) (are against type a and type b influenza)

Front 8

This drug is used for severe RSV?

Back 8

ribavirin

Front 9

this drug can also be used for the tx of hep c if used with Interferon-alpa-2b

Back 9

ribavirin

Front 10

_________and __________prevents ~80% infection if tx begun at time or prior to exposure to virus (its good for high risk pts that don't get vaccinated and during epidemics)

Back 10

amantidine & rimantidine

Front 11

which of the hepatitises (two of them) are there drugs for which its chronic hepatitis

Back 11

hep B/C

Front 12

tx for hep b?

Back 12

interferon alpha (AI)

Front 13

tx for hep c

Back 13

interferon alpha (IA) and ribavirin

Front 14

is hep a chronic?

Back 14

no

Front 15

interferes with the ability of virus to infect cells

Back 15

MOA of interferon

Front 16

The tx for herpes MOA is during the ________ phase viral infection (inhibit DNA snythesis) but not during the ______ phase

Back 16

during acute phase
not during latent phase

Front 17

this is the tx for hsv 1 & 3 & varicella zoster virus & HSV encephalitis & genital herpes (can also be used prophylitically)

Back 17

acyclovir

Front 18

this drug has greater availability than acyclovir; it is good as an IV-acyclovir

Back 18

valacyclovir (valtrex)

Front 19

this is an analog to acyclovir but is 20xs better against cmv

Back 19

ganaclovir

Front 20

good for cmv retinitis if have aids

Back 20

cidofovir

Front 21

for cmv retinitis
for acyclovir resistant hsv
and herpes zoster infection

Back 21

foscarnet

Front 22

what does HAART stand for and is the tx for ??

Back 22

for HIV; highly active anti-retroviral therapy (a multi-drug regmine)

Front 23

what are 3 classes of antiretrovirals?

Back 23

NRTIs
NNRTIS
PI

Front 24

what is the current reccomended therapy for HIV?

Back 24

2 NRTI'S w/ PI or NNRTI

Front 25

this anti-retro viral decreases viral load and increases the number of CD4+ cells

Back 25

NRTI

Front 26

this anti-retroviral is negative bc its fatal liver toxicities

Back 26

NRTI

Front 27

this anti-retroviral lacks effect on host blood forming elements and lacks cross-resistant with NRTIs

Back 27

NNRTI

Front 28

this anti-retro viral has a high incidence of hypersensitivity rxns (ie: rashes)

Back 28

NNRTI

Front 29

this anti-retroviral decreases plasma viral load to undetectable levels

Back 29

PI

Front 30

this anti-retroviral is often used for anti-retroviral naive pts

Back 30

PI