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28 Cards in this Set

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define mycology
study of fungi (yeasts/molds) that contain true nuclei, lack chlorophyll, are non-motile (except spore form) and may grow as single cells or finamentous stx
yeasts
single celled
creamy, with blastopores and pseudohyphae
grow at 37 C as buds
molds
.cottony, wooly, vevety, powdery or waxy
.spores and hyphae
.grow at 25 C (see hyphae)
dimorphism
possessing two different phases based on temp -
molds 37C, yeasts 25C
mycelium
'mat' of long strands of hyphae
hyphae
-long strands of cells that intertwine to form a mycelium
-two forms
1. septate ( with wall)
2. aseptate (no wall)
Pityriasis versicolor
tinea versicolor
-nondermatohpyte fungus
-hyperpigmented, well demarcated
-scaling lesions,
-may appear hypopigments on darker skin
-use KOH prep to see hyphae/buds,
-use woods lamp to see yellow-green color
pityrosporum
malassezia furfur or ovalis
- similar to P. versicolor
woods lamp colors for
1. tinea capitis
2. tinea corporis
3. tinea versicolor
4. vitiligo
1. gray or green
2. blue-green
3. yellow-green
4. willnot flouresce and will on ly reflect light
Tinea Nigra
exophilia werneckii
superficial mycosi
dk brown to black
painless
septate hyphae
PALMS AND SOLES
how do you test for T. Nigra?
KOH prep using scraping - to reveal septate hyphae
-SABOURAUD GLUCOSE AGAR
Black piedra/white piedra
piedraia hortae
hard, black nodules on scalp hair
-Trichospron beigeli - light brown, soft nodules, can affect FACIAL AND GENITAL AREAS as well as SCALP
name 6 Tinea cutaneous mycoses
T. capitis
T. corporis
T barbae
T. cruirs
T pedis
T unguium
Tinea capitis
scalp, no pruitis, circular alopecia
Tinea corporis
pruitic
annular
central clearing
borders elevated and scaly
Tinea Cruris
jock itch
SPARES THE SCROTUM
Tinea Pedis
athletes foot
reaction - hypersensitive
allergic response
see vessicles on hands
Tinea Unguium
thickened, discolored brittle nails
sporotrichosis
subcutaneous fungus
gardeners, greenhouse wkers
-soil, plants, wood, moss
result of puncture w/ splinter
incubation - 1 wk - 6mo
nodule >necrotic ulcer
sporotrichosis - what does it affect, how to tx
affects lymphatics
tx =oral KI if local, or Amphotericin B if disseminated
Mycetoma - describe growth and s/s
slow growing, subQ lesions, affect extremities
-chara by bone deformity and oozing sinus tract
what is known as Darlings disease?
Histoplasmosis
Histoplasmosis
cx
transmission
incubation
dx
s/s
tx
bird and BAT feces
inhalation of spores
3-21 days
Ag detected in RIA urine or serum - DNA probe, sputum
complement fixation, Ab 1:32 titers w/ 75%-95% + post 6 weeks
s/s = pulm disx, mimics TB
Tx - amphotericin B
what mycoses can be tx with Amphotericin B?
histoplasmosis
Cryptococcus
sporotrichosis
Coccidioides immitus
transmission
s/s
labs
tx
SW US (Ca, Az)
inhaled spores
65% asympt, may see ERYTHEMA NODOSUM OR ERYTHEMA MULTIFORME, ASYMMETRICAL ARTHRITIS
-lab - WBC <10k, eosiniphilia, elev ESR
-grown on cotton on BAP
-Ab titers >1:16 suggest extrapulmonary infx
>2 fold titer = dissemination
most resolve w/out tx, and have lifelong immunity
Cryptococcus neoforms
ONLY pathogenic fungus to form a capsule
-see in IMC host -
-presents as meningitis in HIV w/ CD4 <100
-altered mental
hallmark test = India Ink , see Ag in blood or CSF
CSF - eleve WBC, PRO, low glucose
-Tx - amphotericin B or Diflucan
Gilchrist's Disease
Blastomyces dermatidis
most asypmt,
inhalation
s/s - pulmonary,cutaneous (ulcerated granulomas)or systemic
NO serologic skin test = Xreactivity w/ Histoplasma
Paracoccidiodes brasiliensis
S. America - brazil
starts as pulmonary, becomes ulcerative lesions in mouth, nose,
then lymph nodes and viscera involved