Arcadia Clin Dx Exam Ii Arcadia -Ebv And Hepatitis

Front 1

Acute EBV what do you see with lab test?

Back 1

IgM monospot, Anti-VCA IgM and IgG, Anti-EA-D

Front 2

In past EBV see ?

Back 2

Anti-VC IgG, and anti-EBNA

Front 3

Chronic EBV tests positive for

Back 3

Anit-VCA IgG and Anti-EA-D, anti-EA-R, Anti-EBNA

Front 4

Burkitts lymphoma

Back 4

Tests positive for anit-VCA IgG, Anti-EA-R, anti-EBNA, maybe anti-EA-

Front 5

Nasopharygeal carcinoma

Back 5

Positive for Anti-VCA IgG, anti-EA-D, may be anti-EA-R, anti-EBNA

Front 6

All that test positive for Anti-VCA IgM

Back 6

Only acute EBV mono

Front 7

All that test positive for anti-VCA IgG?

Back 7

All EBV diseases

Front 8

When will you not see a positive test result for anti-EA-D?

Back 8

Past EBV infection

Front 9

Those that test positive for anti-EA-R

Back 9

Chronic active EBV
Burkitts lymphoma
Nasopharyngeal ( can be +/-)

Front 10

Which EBV does NOT tests positive for anti-EBNA?

Back 10

Acute EBV - mono

Front 11

what is the first antigen to appear on EBV serology?

Back 11

EBNA - antibodies for EBNA can develop late in the infx

Front 12

what is teh use of EIA test with EBV?

Back 12

serological test to detect antibody against EBV components

Front 13

when does anti-VCA appear?

Back 13

early in infection, 1-2 month duration

Front 14

when does Anti-EBNA develop?

Back 14

around 3-6 weeks, and has life-long duration

Front 15

recent infection displays what on test?

Back 15

presence of anti-VCA, but NOT anti-EBNA

Front 16

past infection displays what on test?

Back 16

presence of BOTH anti-VCA and anti-EBNA

Front 17

what is significant about Ab's and recovery of EBV?

Back 17

anti-EA and anti-VCA decr, and anti-EBNA persists lifelong and will represent a past infection if test later in life

Front 18

T/F ONLY anti-EBNA appears on test post 2+years of EBV infection?

Back 18

FALSE, anti-VCA and anti-EBNA are ALWAYS present, just in lower titer amounts, sometims see anti-EA as well

Front 19

T/F a negative monospot result means the pt does NOT have mono?

Back 19

FALSE, a negative result can happen if early in illness. also look for anti-VCA IgM

Front 20

T/F, AST is < than ALT in hepatitis virus?

Back 20

FALSE, the usual report is AST>ALT

Front 21

hepatitis A

Back 21

fecal/oral transmission
or from shellfish
once have = lifelong immunity
-vaccine= Havrix

Front 22

what about surface antigen an dlifelong immunity or being a carrier?

Back 22

1. see hepatitis surface Ag, in response you will make HVB surface Ab - (if you never make the Ab, it means you are a carrier, if you do make it - it confers lifelong immunity)
2.

Front 23

describe the antigen/antibody timeline of hepatitis B infection

Back 23

1. HBs Ag appears first during incubation period, then dissappears
2. during 'core window" have peak ALT, s/s of virus, IgG anti-HBc, IgM anti-HBc
3. see HbsAg at end of window,~4mo post infx, see HBeAg around 3 mo, develop HBV DNA ~3 mo
4. anti-HBc is detected in serum when symptoms begin
5. antiHBc IgM develops 1st, followed by IgG
6. if see HBeAg, it predicts development of chronic hep B
**high levels of HBeAg = good prognosis

Front 24

which anti-HBcIg can be tested during core window of Hep B?

Back 24

ONLY the anti-HBc IgM
there is NO test for the anti-HBc IgG

Front 25

where is HBV core antigen found in the body?

Back 25

only in liver cells

Front 26

which Ig is present for life in post infected Hep B pt?

Back 26

IgG

Front 27

what is the best test to do if there is a questionable positive Hep C test result?

Back 27

do a PCR and RIBA-2

Front 28

what is the most common source of post transfusion hepatitis?

Back 28

hep C, 70% become chronic

Front 29

who can present with a false + hep C test result?

Back 29

pt w/ autoimmune disx or incr gamma globulins

Front 30

what are the vaccines for hepatitis, and which strain does not have a vaccine available?

Back 30

Havris -HVA (hep A)
Twinrix - Hep B
none for C,D,E

Front 31

describe Hep D

Back 31

delta, RNA virus, can replicate ONLY when hep B is present
-can test for tthe antibody

Front 32

hepatitis E

Back 32

waterborne hep mainly in underrdeveloped countries
transmission is fecal/oral

Front 33

what two strains of hepatitis can be transmitted via fecal/oral route?

Back 33

hep A and hep E

Front 34

which strains of hepatitis can cause chronic disease?

Back 34

hep B,C,D,

Front 35

which strains of hepatitis can cause cirrhosis and hepatocellular carcinoma?

Back 35

hep B and C

Front 36

list the vaccines available for hepatitis

Back 36

Recombivax - for hep B Twinrix - combo for hep A/B
Havrix - hep A
no vaccine for hep C,D,E