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18 Cards in this Set

  • Front
  • Back
What are the four stages of respiration?
Glycolysis, link reaction, Krebs cycle, electron transport chain
What happens in glycolysis? (Basic)
Splitting of 6C glucose into two 3C pyruvate molecules
What happens in the link reaction? (Basic)
Conversion of 3C pyruvate into carbon dioxide and 2C molecule called acetylcoenzyme A
What happens in the Krebs cycle? (Basic)
The introduction of acetyl CoA into a cycle of oxidation-reduction reactions that yield some ATP and a large number of electrons
What happens in the ETC? (Basic)
The use of the electrons produced in the Krebs cycle to synthesise ATP with water produced as a by-product
What are the four main stages of glycolysis?
Activation of glucose by phosphorylation

Splitting of phosphorylated glucose (into TP)

Oxidation of TP

Production of ATP

--> Formation of Pyruvate
What is the product of glycolysis?
Net gain of two ATP molecules

Two molecules of RNAD

TWO molecules of Pyruvate
Where are the enzymes for glycolysis found?
In the CYTOPLASM of cells - does NOT require any organelle or membrane - no oxygen required
Where does the link reaction/Krebs cycle take place in eukaryotic cells?
The mitochondria
The pyruvate molecules produced in the cytoplasm during __________ are actively transported into the ______ of the ____________
glycolysis, matrix, mitochondria
What happens to pyruvate in its conversion to acetyl CoA?
It is oxidised by removing hydrogen (which is accepted by NAD)

Carbon dioxide is lost

The 2C compound (acetyl group) combines with CoA to form Acetyl CoA
Pyruvate + NAD + CoA -->
Acetyl CoA + RNAD + Carbon dioxide
Where is the carbon dioxide produced in respiration?
Directly form the molecules involved in the link reaction and Krebs cycle
What is produced from one molecule of pyruvate in the Krebs cycle?
Reduced coenzymes (NAD and FAD)

1 ATP molecule

3 Carbon dioxide molecules

Remember this is *2 for total products
What does NAD do?
It works with dehydrogenase enzymes that catalyse the removal of hydrogen ions from substrates and transfer them to other molecules such as the hydrogen carriers involved in oxidative phosphorylation
What is the significance of the Krebs cycle? (I.e. what happens?)
Macromolecules are broken down

Hydrogen atoms are produced that are carried by NAD to the ETC for oxidative phosphorylation

It regenerates the 4C molecule that would otherwise accumulate

It's a source of intermediate compounds used by cells in the manufacture of other important substances such as fatty acids, amino acids and chlorophyll
What's special about the mitochondria of cells that have a high metabolic rate?
They are more densely packed with cristae
What is the importance of oxygen in respiration?
To act as the final acceptor of hydrogen atoms. Without its role in removing H atoms at the end of the chain, the protons would 'back up' and respiration would come to a halt. Cyanide is a non-competitive inhibitor of the final enzyme in the ETC