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22 Cards in this Set
- Front
- Back
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delivers dietary TGs to peripheral tissue
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chylomicron
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delivers hepatic TGs to peripheral tissue
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VLDL
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delivers triglycerides and cholesterol to liver
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IDL
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delivers hepatic cholesterol to peripheral tissues
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LDL
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mediates reverse cholesterol transport from periphery to liver
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HDL
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secreted by intestinal epithelial cells
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chylomicron
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secreted by liver
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VLDL
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formed when VLDL is degraded
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IDL
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formed when lipoprotein lipase modifies VLDL in the peripheral tissue
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LDL
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acts as a repository for apoC and apoE
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HDL
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apoE
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mediates remnant uptake
found on cholomicrons, chylomicron remnants, VLDL, IDL and HDL |
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apoA-I
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activates LCAT- LCAT matures HDL- found on chylomicrons and HDL
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apoC-II
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lipoprotein lipase cofactor
present on chylomicrons and VLDL |
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lipoprotein lipase
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degrades the TG in chylomicrons and VLDL to give to peripheral tissues
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apoB-48
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mediates chylomicron secretion (from intestines)
on chylomicrons and chylomicron remnants |
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apoB-100
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binds the LDL receptor- VLDL, IDL, LDL
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type I dyslipidemia
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lipoprotein lipase deficiency or altered CII
causes pancreatitis, HSM, eruptive and pruritic xanthomas high chylomicrons; elevated TG and cholesterol seen in blood no risk for atherosclerosis |
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type IIa dyslipidemia
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autosomal dominant decreased or absent LDL receptors
causes increased LDL; high cholesterol seen in blood causes accelerated atherosclerosis, tendon xanthomas, corneal arcus |
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type IIb dyslipidemia
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apo B100 defect- high LDL and VLDL- can't get in liver
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type III dyslipidemia
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dysbetalipoproteinemia
ApoE defect- high IDL |
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type IV dyslipidemia
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hepatic overproduction of VLDL causing high VLDL, blood shows high TG-> pancreatitis
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deficiency in B100 or B48
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abetalipoproteinemia
can't synthesize lipoproteins symptoms show in first few months of life- failure to thrive, steatorrhea, acathocytosis, ataxia, night blindness intenstinal biopsy shows accumulation within the enterocytes d/t inability to export absorbed lipid |
