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22 Cards in this Set

  • Front
  • Back
delivers dietary TGs to peripheral tissue
chylomicron
delivers hepatic TGs to peripheral tissue
VLDL
delivers triglycerides and cholesterol to liver
IDL
delivers hepatic cholesterol to peripheral tissues
LDL
mediates reverse cholesterol transport from periphery to liver
HDL
secreted by intestinal epithelial cells
chylomicron
secreted by liver
VLDL
formed when VLDL is degraded
IDL
formed when lipoprotein lipase modifies VLDL in the peripheral tissue
LDL
acts as a repository for apoC and apoE
HDL
apoE
mediates remnant uptake
found on cholomicrons, chylomicron remnants, VLDL, IDL and HDL
apoA-I
activates LCAT- LCAT matures HDL- found on chylomicrons and HDL
apoC-II
lipoprotein lipase cofactor
present on chylomicrons and VLDL
lipoprotein lipase
degrades the TG in chylomicrons and VLDL to give to peripheral tissues
apoB-48
mediates chylomicron secretion (from intestines)
on chylomicrons and chylomicron remnants
apoB-100
binds the LDL receptor- VLDL, IDL, LDL
type I dyslipidemia
lipoprotein lipase deficiency or altered CII

causes pancreatitis, HSM, eruptive and pruritic xanthomas

high chylomicrons; elevated TG and cholesterol seen in blood

no risk for atherosclerosis
type IIa dyslipidemia
autosomal dominant decreased or absent LDL receptors

causes increased LDL; high cholesterol seen in blood

causes accelerated atherosclerosis, tendon xanthomas, corneal arcus
type IIb dyslipidemia
apo B100 defect- high LDL and VLDL- can't get in liver
type III dyslipidemia
dysbetalipoproteinemia

ApoE defect- high IDL
type IV dyslipidemia
hepatic overproduction of VLDL causing high VLDL, blood shows high TG-> pancreatitis
deficiency in B100 or B48
abetalipoproteinemia
can't synthesize lipoproteins
symptoms show in first few months of life- failure to thrive, steatorrhea, acathocytosis, ataxia, night blindness

intenstinal biopsy shows accumulation within the enterocytes d/t inability to export absorbed lipid