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219 Cards in this Set
- Front
- Back
What are the three types of blood vessels?
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arteries, veins, capillaries
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Vessel walls are composed of layers called _____
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tunics
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The inside space of a vessel through which blood flows
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lumen
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What are the three tunics of a blood vessel?
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tunica intima, tunica media, tunica externa
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In an artery, this is thicker than a vein, and this is smaller than a vein.
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tunica media is thicker in an artery than in a vein and the arterial lumen is more narrow than a vein's
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The thickest tunica of a vein
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Tunica externa
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some capillaries only have this layer:
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tunica externa consisting of an endothelium and a basement membrane
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do capillaries have a subendothelial layer?
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no
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what is another name for tunica intima?
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tunica interna
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what is the tunica intima made up of?
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endothelium (simple squamous epithelium) and a thin subendothelial layer made up of areolar connective tissue
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this layer is continuous with the endocardium
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tunica intima
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this layer of vessel wall is made up circularly arranged smooth muscle fibers supported by elastic fibers
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tunica media
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contraction of the smooth muscle in this tunica cause vasoconstriction
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tunica media
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relaxation of the smooth muscle in this tunica causes vasodilation
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tunica media
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another name for tunica externa
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tunica adventitia
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another name for tunica adventitia
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tunica externa
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this tunica is composed of areolar connective tissue that contains elastic and collagen fibers
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tunica externa
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this tunica helps anchor vessels to their structures
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tunica externa
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what is the vaso vasorum?
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very large vessels require blood supply to the tunica externa. vaso vasorum is this network of blood supply.
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Arteries and veins that supply the same body region and tend to lie next to each other are called _______
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companion vessels
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an artery/vein remains patent when there is no blood in it.. why?
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artery
there are more elastic fibers and a thicker tunica media that hold its shape |
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Artery or vein?
1 - Narrower lumen 2 - General wall thickness...thicker 3 - flattened cross-sectional shape 4 - tunica media is the thickest tunica 5 - tunica externa is the thickest tunica 6 - has more elastic fibers 7 - valves present 8 - lower blood pressure9 9 - transports blood toward the heart |
1 - artery
2 - artery 3 - vein 4 - artery 5 - vein 6 - artery has more than vein 7 - most veins 8 - veins 9 - veins |
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Having only the tunica intima allows for what with capillaries?
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Rapid gas and nutrient exchange between blood and tissues
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What are the three types of arteries?
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elastic arteries, muscular arteries, arterioles
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List the three types of arteries in order from smallest to largest
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arterioles, muscular artieries, elastic arteries
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These are the largest arteries (elastic/muscular/arterioles) with a diameter of _____
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elastic arteries
2.5 to 1 cm |
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These are called conducting arteries because they conduct blood from the heart to the smaller, muscular arteries
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elastic arteries
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The tunics with large amounts of elastic fibers in elastic arteries
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All three tunics have large amounts of elastic fibers
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ventricular contraction
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systole
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ventricular relaxation
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diastole
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Examples of elastic arteries are _____
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aorta
pulmonary trunk brachiocephalic common carotid subclavian common iliac |
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Elastic arteries branch into _____
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muscular arteries
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Muscular arteries have diameters ranging from ____ to _____
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1 cm to 3 mm
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These are also called distributing arteries
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muscular arteries
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In ______ arteries, the elastic fibers are confined to two circumscribed sheets: The internal elastic lamina separates the _______ from the ______, and the external elastic lamina separates the _____ from the _____
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muscular;
tunica intima from the tunica media tunica media from the tunica externa |
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LIst some muscular arteries:
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brachial, anterior tibial, coronary, and inferior mesenteric arteries
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These are the smallest arteries:
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arterioles
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What is the size range of arterioles?
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from 3mm to 10 micrometers
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How many layers of smooth muscle do arterioles have in their tunica media?
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fewer than six
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Vasomotor tone is regulated by ______
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vasomotor center of the brainstem
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What is vasomotor tone?
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the constant slightly constricted state of arterioles
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_____ is a progressive disease of the elastic and muscular arteries.
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artherosclerosis
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Artherosclerosis is characterized by the presence of _____
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atheroma or atheromatous plaque, which leads to thickening of the tunica intima and narrowing of the arterial lumen
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What is the response-to-injury hypothesis
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states that injury to the endothelium of an arterial wall, especially repeated injury caused by infection, trauma, or hypertension, results in an inflammatory reaction, eventually leading to the development of an atheroma.
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_____ has been positively associated with the rate of development and severity of atherosclerosis
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hypercholesterolemia
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Why do smoking and hypertension have increased risks of atherosclerosis?
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because they cause vascular injury
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What are two options for treating atherosclerosis surgically?
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angioplasty and placement of a stent
bypass using a vein from elsewhere in the body |
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Where do aneurysms most occur?
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arteries at the base of the brain or in the aorta
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What is an aneurysm?
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part of the arterial wall thins and balloons out
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Capillaries connect _____ to _____
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arterioles to venules
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What is the average length and diameter of a capillary?
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1mm in length
8-10 micrometers in diameter |
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Capillaries consist solely of a ____ and a _____
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endothelial layer resting on a basement membrane
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What are the three types of capillaries?
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continuous, fenestrated, sinusoids
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Describe a continuous capillary:
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lining of endothelial cells is complete around the lumen; basement membrane is complete; intercellular clefts exist between endothelial cells
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Describe a fenestrated capillary:
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Same as continuous capillary except the cells contain fenestrations, or holes, ranging from 10 to 100 nanometers in diameter
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Describe sinusoid capillary:
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Lining of endothelial cells is incomplete around the lumen; basement membrane is incomplete or absent
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What passes through a continuous capillary?
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some leukocytes, plasma and its contents (except most proteins)
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What passes through a fenestrated capillary?
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Large amounts of materials are filtered, released or absorbed; some smaller proteins
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What passes through a sinusoid capillary?
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Large substances (formed elements, large plasma proteins, and plasma)
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List some locations of continuous capillaries:
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most capillaries are continuous
capillaries within muscles, skin, thymus, lungs, and central nervous system |
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List some locations of fenestrated capillaries:
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small intestine for absorbing nutrients
ciliary process to produce aqueous humor choroid plexus to produce cerebral spinal fluid in the brain most endocrine glands, permit absorption of hormones into the blood kidneys for filtering blood |
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List some locations of sinusoid capillaries:
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bone marrow where formed elements enter the blood
liver and spleen where old erythrocytes are phagocytized by macrophages and taken out of circulation some endocrine glands such as the anterior pituitary, adrenal, and parathyroid |
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What kind of junctions secure endothelial cells together in continuous capillaries?
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tight junctions
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The gaps between endothelial cells of continuous capillaries are called:
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intercellular clefts
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What can fit between intercellular clefts of continuous capillaries?
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glucose, amino acids, ions
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What is another name for sinusoid capillaries?
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discontinuous capillaries
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Define the blood brain barrier
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modified continuous capillaries
have thickened basement membrane no intercellular clefts |
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What is a capillary bed
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a group of 10 to 100 capillaries functioning together
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what feeds a capillary bed?
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metarteriole, which is a branch of an arteriole
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The _____ part of a metarteriole is encircled by smooth muscle cells, and the _____ part has no smooth muscle cells
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proximal; distal
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what is the distal part of a metarteriole called?
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thoroughfare channel
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Do thoroughfare channels have smooth muscle cells?
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No
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The thoroughfare channel of a capillary bed connects to a _______
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postcapillary venule
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True capillaries branch from the ______
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thoroughfare channel
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What regulates blood flow into true capillaries?
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precapillary sphincters
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This makes up the bulk of a capillary bed
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true capillaries
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precapillary sphincters go through cycles of contracting and relaxing at a rate of about 5 - 10 cycles per minute. This cyclical process is called _____
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vasomotion
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vasomotion
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precapillary sphincters go through cycles of contracting and relaxing at a rate of about 5 - 10 cycles per minute.
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the specific amount of blood entering capillaries per unit time per gram of tissue is called
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perfusion
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perfusion
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the specific amount of blood entering capillaries per unit time per gram of tissue
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perfusion is typically expressed ______
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millimeters per minute per gram
mL/min/g |
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____ are the smallest veins
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venules
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what is the range of size of venules?
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from 8-100 micrometers in diameter
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venules are companion vessels with _____
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arterioles
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What are the smallest venules?
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postcapillary venules
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What drains capillaries?
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post capillary venules
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do any venules have all three tunics?
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yes, the largest do
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What merges to form veins?
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venules
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a venule becomes a vein when its diameter is greater than ______ micrometers
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100
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small and medium-sized veins are companion vessels with ______
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muscular arteries
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the largest veins are companion vessels with _____
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elastic arteries
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Is blood pressure in veins high enough to overcome the forces of gravity?
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no
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What characteristic do veins have that prevent blood from pooling in the limbs?
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valves
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Vein valves are formed primarily by ____ and strengthened by ______
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tunica intima
elastic and collagen fibers |
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Valves have an anatomic structure similar to ______
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semilunar valves of the heart
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What are the percentages of blood in the pulmonary, cardiac, systemic circulation at rest?
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pulmonary = 18%
heart = 12% systemic circulation = 70% about 55% of systemic is in veins about 10% of systemic is in arteries about 5% in capillaries |
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A modified vein that has very thin walls and no smooth muscle is referred to as a _____
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sinus
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What is a sinus?
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a modified vein that has very thin walls and no smooth muscle
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What are two examples of sinuses?
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coronary sinus and dural venous sinuses
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How does a vein serve as a blood reservoir?
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Vasoconstriction moves blood from the veins and into other parts of the circulation. Vasodilation of veins allows it to flow back into the veins as reserves
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What are the two ways blood vessels are arranged?
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simple pathway
alternative pathway |
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_____ use one major artery, one capillary bed, and one major vein to deliver blood to a body region
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simple pathways
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Define simple pathways
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use one major artery, one capillary bed, and one major vein to deliver blood to a body region
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What two kinds of alternative pathways are there?
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anastomoses and portal systems
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Give an example of an organ with a simple pathway
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spleen
the splenic artery delivers oxygenated blood to the spleen with the exchange made in a capillary bed of the spleen, and a single splenic vein drains deoxygenated blood from the spleen |
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Arteries that provide only one pathway through which blood can reach an organ are referred to as _____
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end arteries
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What are end arteries?
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Arteries that provide only one pathway through which blood can reach an organ
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What is the function of capillaries?
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To allow for the exchange of substances such as respiratory gases, nutrients, wastes, and hormones between the blood and the surrounding tissues
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What are three exchange processes at capillaries?
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diffusion, vesicular transport, and bulk flow
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What substances are transported by diffusion through the capillaries?
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glucose, ions, oxygen, carbon dioxide
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What substances leave the capillaries by vesicular transport?
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insulin, fatty acids
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What is vesicular transport?
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endothelial cells use pinocytosis to fuse fluid-filled vesicles with the plasma membrane and transport their contents to and from blood and interstitial fluids
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What is bulk flow?
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the movement of large amounts of fluids and their dissolved substances in one direction down a pressure gradient
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Filtration is a process that occurs at the _____ end of a capillary
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arterial
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_____ is the bulk flow of movement at the arterial end of a capillary through fenestrations or between intercellular clefts.
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Filtration
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_____ is the opposite of filtration and occurs at the _____ end of the capillary
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reabsorption; venous
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What are the two types of pressures at a capillary?
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hydrostatic in the blood and hydrostatic at the tissues
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What is BCOP?
is it an inward or outward force? |
blood colloid osmotic pressure
inward |
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What is the outward force in bulk transport?
Inward? |
blood hydrostatic pressure
blood colloid osmotic pressure |
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What is the formula for net hydrostatic pressure?
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blood hydrostatic pressure in blood minus blood hydrostatic pressure in interstitial tissues
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What is the formula for net blood colloid osmotic pressure?
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colloid osmotic pressure in the blood minus colloid osmotic pressure in the interstitial tissues
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How do you calculate net filtration pressure at a capillary during bulk flow?
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(HPblood - HPif)-(COPblood-COPif) = NFP
(35-0) - (26 - 5) = NFP 35 - 21 = 14 mmHg arterial end |
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Define hydrostatic pressure
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the physical force exerted by a fluid on a structure
blood hydrostatic pressure (blood pressure) is the force exerted per unit area by the blood as it presses against the vessel wall |
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______ promotes filtration from a capillary
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blood hydrostatic pressure
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This is the force of the interstitial fluid on the external surface of the blood vessel
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interstitial fluid hydrostatic pressure
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What are the two forces regulating filtration and absorption at the capillary?
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hydrostatic pressure and colloid osmotic pressure
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Does osmosis push or pull water?
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pulls due to higher relative concentration of solutes
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_____ refers to the pull of water back into a tissue by the tissue's concentration of proteins (colloid)
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colloid osmotic pressure (COP)
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_____ is the force that draws fluid back into the blood due to the proteins in the blood, such as albumin
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blood colloid osmotic pressure
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______ opposes hydrostatic pressure
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blood colloid osmotic pressure
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What is another term for blood colloid osmotic pressure?
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oncotic pressure
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what is another name for oncotic pressure?
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blood colloid osmotic pressure
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The NFP equation is a variation of ______
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Starling's Law
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What are the typical figures at an arterial end and venous end of a capillary?
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Arterial:
HPb = 35 HPif = 0 BCOPb = 26 BCOPif = 5 NFP: 14mmHg Venous: HPb = 16 HPif = 0 BCOPb = 26 BCOPif = 5 NFP: 5mmHg |
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Is it possible for blood pressure to decrease to such a degree that capillary exchange ceases? Explain
|
Yes
Not enough volume to facilitate pressure for filtration |
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What are the three factors determining the amount of blood delivered to a specific organ or tissue?
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1 - the degree of vascularization of the tissue
2 - local regulatory factors that alter blood flow 3 - total blood flow |
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______ determines the potential ability of blood delivery
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degree of vascularization
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The amount of vascularization in a given tissue may change over time through _____
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angiogenesis
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_____ is the formation of new blood vessels in tissues that require them
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angiogenesis
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When does angiogenesis occur?
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weight gain, aerobic exercise, in response to occlusions etc
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What is regression?
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The opposite of angiogenesis
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Formation of blood vessels within a tumor
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tumor angiogenesis
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_____ is the process by which a tissue itself regulates or controls its local blood flow in response to its changing metabolic needs
|
autoregulation
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There is a negative feedback loop between elevated levels of ____, ____, ____, and ____, which act as vasodilators.
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K+, H+, carbon dioxide, lactic acid
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After temporary disruption in blood flow is returned and blood flow is restored, the marked increase in blood flow to the affected tissue is called _______
|
reactive hyperemia
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_____ compensates for temporary lack of blood which is returned in order to get rid of the extra waste and bring extra nutrients
|
reactive hyperemia
|
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When you return to a warm area after being in the cold and your cheeks are red is an example of
|
reactive hyperemia
|
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These two vasochemicals are released in response to tissue trauma
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histamine and bradykinin
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_____ is a very powerful but short-lived vasodilator released from endothelial cells
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nitric oxide
|
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_____ is the amount of blood transported throughout the entire vasculature in a given period of time
|
total blood flow
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_____ = cardiac output (term)
|
total blood flow
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What is the average cardiac output?
|
5.25 L/min
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Define blood pressure
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the force per unit area that blood exerts against the inside wall of a vessel
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A _____ is the change in blood pressure from one end of a blood vessel to its other end
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blood pressure gradient
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systolic pressure - diastolic pressure = _____
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pulse pressure
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systolic pressure occurs during ventricular _____ and diastolic pressure occurs during ventricular _____
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contraction; relaxation
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_____ is the additional pressure placed on the artery from when the heart is relaxing to when it is contracting
|
pulse pressure
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What are the two values that can be calculated from systolic pressure and diastolic pressure?
|
pulse pressure and mean arterial pressure
|
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A possible consequence of an elevated MAP is _____
|
cerebral edema
|
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Why does excess fluid remain in the interstitial fluids at the brain?
|
there are no lymph vessels to help drain it
|
|
MAP
|
mean arterial pressure
average measure of the blood pressure forces on the arteries MAP = Diastolic pressure + 1/3pulse pressure |
|
DVT
|
deep vein thrombosis
blood clot (thrombus) in the vein |
|
The most serious complication of a DVT
|
pulmonary embolus
|
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Is there a pulse pressure at capillaries?
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No, blood flow is smooth and even at the capillaries
|
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Is there a blood pressure in venules?
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No. Too far from the heart and not influenced by the pumping action of the heart
|
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Two ways venous return is aided to overcome low pressure:
|
skeletal muscle pump within the limbs and respiratory pump within the torso (inhalation causes muscles to contract in the abdomen around the IVC)
|
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What causes vericose veins?
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Valves in the veins have become nonfunctional causing pooling and the veins to swell and bulge
|
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_____ is the amount of friction the blood experiences
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resistance
|
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______ is resistance in blood vessels
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peripheral resistance
|
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What increases peripheral resistance?
|
viscosity, length of vessels; vessel radius
|
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the difference in flow rate within a blood vessel is called _____
|
laminar flow
|
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The relationship between blood flow and radius
|
F (is proportional to) r^4
in mm/sec |
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vasoconstriction and vasodilation of arterioles is controlled how?
|
systemically by the sympathetic division of the ANS
|
|
Mathematically express the relationship of blood pressure gradients and resistance:
|
F (is proportional to) delta P/resistance
delta P = P1-P2 (pressure gradient) |
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Is blood flow inversely or directly related to resistance?
|
inversely
if resistance goes up, blood flow goes down |
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Blood pressure is dependent on three primary variables:
|
cardiac output, resistance, and blood volume
|
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The cardiovascular center in the medulla oblongata receives signals from _____ and _____ in the _____ and the _____
|
chemoreceptors; baroreceptors; aortic arch; carotid arteries
|
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How does the cardiovascular center regulate blood pressure?
|
through motor output from sympathetic nerves and vagus nerves by adjusting cardiac output and peripheral resistance experienced by blood in blood vessels
|
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What are the three sub-centers of the cardiovascular center
|
cardioacceleratory center;
cardioinhibitory center vasomotor center |
|
vessels innervated by _____ fibers vasoconstrict
|
adrenergic
|
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vessels innvervated by ______ fibers vasodilate
|
cholinergic
|
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carotid and aortic bodies contain _____
|
chemoreceptors
|
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where are baroreceptors?
|
aortic arch and carotid sinus of external carotid
|
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The _____ regulates heart activity and thus cardiac output
|
cardiac center
|
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The _____ controls the degree of vasoconstriction of blood vessels and thus regulates resistance
|
vasomotor center
|
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sympathetic division pathways extend from the cardioacceleratory center to ______ and _____
|
SA node; myocardium
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Increased sympathetic output from the cardioacceleratory center does what?
|
increases heart rate and force of contraction, increasing cardiac output
|
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Parasympathetic division pathways extend from the cardioinhibitory center to _____ and _____
|
SA node; AV node
|
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Increased parashympathetic motor output from the cardioinhibitory center does what?
|
decreases heart rate and slows the conduction of electrical signals through the heart's conducting system, decreasing cardiac output
|
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vasomotor center:
sympathetic division pathways extend from the _____ to ______ |
vasomotor center to the blood vessels
|
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What are the two primary receptors associated with the smooth muscle within the wall of vessels?
|
alpha (a) receptors
beta (B) receptors |
|
Blood vessels containing a receptors _____ in response to sympathetic stimulation
what vessels have alpha receptors? |
contract
most vessels of the body |
|
blood vessels containing B receptors ______ in response to epinephrine (sympathetic) stimulation
What vessels have beta receptors? |
relax
vasodilation skeletal muscle and coronary vessels |
|
Activation of the vasomotor center and increased nerve signals along sympathetic pathways cause ___, ___, and ___
|
increased peripheral resistance
larger circulating blood volume redistribution of blood flow |
|
_____ are specialized sensory nerve endings that respond to the stretch in blood vessel walls
|
baroreceptors
|
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Where are the aortic arch and carotid sinus baroreceptors located
|
tunica externa of the aortic arch
tunica externa of each internal carotid artery |
|
What nerve sends signals from aortic arch baroreceptors to the cardiovascular center?
|
vagus nerve CNX
|
|
the aortic arch transmits signals to the brain via _____ and the carotid sinuses transmit signals to the brain via _____
|
vagus nerve CNX
glossopharyngeal nerve IX |
|
baroreceptors activate and initiate _____
|
baroreceptor reflexes
|
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____ is chronically elevated blood pressure
|
hypertension
|
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_____ is chronically low blood pressure
|
hypotension
|
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_____ is a drop in blood pressure when a person suddenly changes position
|
orthostatic hypotension
|
|
primary function of chemoreceptors; secondary?
|
regulating respiration
regulating bp |
|
result of chemoreceptor stimulation
|
chemoreceptor reflexes
|
|
The two main peripheral chemorecptors are:
|
aortic bodies; carotid body
|
|
chemoreceptors primarily stimulates _____
|
vasomotor centers
|
|
The _____ alters blood pressure in response to emotion
|
limbic center
|
|
What hormones participate in regulating hormones?
|
epinephrine and norepinephrine
angiotensin II antidiuretic hormone aldosterone atrial natriuretic peptide |
|
This straddles short-term neural bp regulation and long-term hormonal regulation
|
renin-angiotensin system
|
|
what hormone is associated with the renin-angiotensin system?
|
angiotensin II
|
|
Why is angiotensin II involved in both neural and hormonal bp regulation?
|
it is initiated by the nervous system and it causes the release of other long term hormones
|
|
_____ is an inactive hormone produced by the liver and secreted into the blood. It is converted to ______ by ____, an enzyme released by the kidney in response to low BP at the kidney. It is then converted to ______ by ______, which is an enzyme associated with the capillary endothelium (mostly in the lungs)
|
angiotensinogen
angiotensin I; renin angiotensin II; angiotensin-converting enzyme (ACE) |
|
What three things does angiotensin II do to increase blood pressure?
|
causes vasoconstriction
stimulates the thirst center decreases urnin formation |
|
When is aldosterone released? From where? What does it do?
|
Released from the adrenal cortex in response to angiotensin II. It increases absorption of NA+ and water in the kidney, decreasing their loss in the urine.
|
|
_____ is released from the atrium of the heart in response to increase blood volume
|
atrial natriuretic peptide
|
|
What is the net effect of the release of ANP?
How? |
decrease in blood pressure
ANP stimulates vasodilation, which decreases resistance and increases urine output, which decreases blood volume |
|
Three primary factors influence blood pressure:
|
cardiac output, peripheral resistance and blood volume
|
|
The rate of blood transported per unit time
|
blood flow velocity
|
|
What is the pulmonary circulation responsible for?
|
carrying deoxygenated blood from the R heart to the lungs then returning oxygenated blood to the L heart
|