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219 Cards in this Set

  • Front
  • Back
What are the three types of blood vessels?
arteries, veins, capillaries
Vessel walls are composed of layers called _____
tunics
The inside space of a vessel through which blood flows
lumen
What are the three tunics of a blood vessel?
tunica intima, tunica media, tunica externa
In an artery, this is thicker than a vein, and this is smaller than a vein.
tunica media is thicker in an artery than in a vein and the arterial lumen is more narrow than a vein's
The thickest tunica of a vein
Tunica externa
some capillaries only have this layer:
tunica externa consisting of an endothelium and a basement membrane
do capillaries have a subendothelial layer?
no
what is another name for tunica intima?
tunica interna
what is the tunica intima made up of?
endothelium (simple squamous epithelium) and a thin subendothelial layer made up of areolar connective tissue
this layer is continuous with the endocardium
tunica intima
this layer of vessel wall is made up circularly arranged smooth muscle fibers supported by elastic fibers
tunica media
contraction of the smooth muscle in this tunica cause vasoconstriction
tunica media
relaxation of the smooth muscle in this tunica causes vasodilation
tunica media
another name for tunica externa
tunica adventitia
another name for tunica adventitia
tunica externa
this tunica is composed of areolar connective tissue that contains elastic and collagen fibers
tunica externa
this tunica helps anchor vessels to their structures
tunica externa
what is the vaso vasorum?
very large vessels require blood supply to the tunica externa. vaso vasorum is this network of blood supply.
Arteries and veins that supply the same body region and tend to lie next to each other are called _______
companion vessels
an artery/vein remains patent when there is no blood in it.. why?
artery
there are more elastic fibers and a thicker tunica media that hold its shape
Artery or vein?
1 - Narrower lumen
2 - General wall thickness...thicker
3 - flattened cross-sectional shape
4 - tunica media is the thickest tunica
5 - tunica externa is the thickest tunica
6 - has more elastic fibers
7 - valves present
8 - lower blood pressure9
9 - transports blood toward the heart
1 - artery
2 - artery
3 - vein
4 - artery
5 - vein
6 - artery has more than vein
7 - most veins
8 - veins
9 - veins
Having only the tunica intima allows for what with capillaries?
Rapid gas and nutrient exchange between blood and tissues
What are the three types of arteries?
elastic arteries, muscular arteries, arterioles
List the three types of arteries in order from smallest to largest
arterioles, muscular artieries, elastic arteries
These are the largest arteries (elastic/muscular/arterioles) with a diameter of _____
elastic arteries
2.5 to 1 cm
These are called conducting arteries because they conduct blood from the heart to the smaller, muscular arteries
elastic arteries
The tunics with large amounts of elastic fibers in elastic arteries
All three tunics have large amounts of elastic fibers
ventricular contraction
systole
ventricular relaxation
diastole
Examples of elastic arteries are _____
aorta
pulmonary trunk
brachiocephalic
common carotid
subclavian
common iliac
Elastic arteries branch into _____
muscular arteries
Muscular arteries have diameters ranging from ____ to _____
1 cm to 3 mm
These are also called distributing arteries
muscular arteries
In ______ arteries, the elastic fibers are confined to two circumscribed sheets: The internal elastic lamina separates the _______ from the ______, and the external elastic lamina separates the _____ from the _____
muscular;
tunica intima from the tunica media
tunica media from the tunica externa
LIst some muscular arteries:
brachial, anterior tibial, coronary, and inferior mesenteric arteries
These are the smallest arteries:
arterioles
What is the size range of arterioles?
from 3mm to 10 micrometers
How many layers of smooth muscle do arterioles have in their tunica media?
fewer than six
Vasomotor tone is regulated by ______
vasomotor center of the brainstem
What is vasomotor tone?
the constant slightly constricted state of arterioles
_____ is a progressive disease of the elastic and muscular arteries.
artherosclerosis
Artherosclerosis is characterized by the presence of _____
atheroma or atheromatous plaque, which leads to thickening of the tunica intima and narrowing of the arterial lumen
What is the response-to-injury hypothesis
states that injury to the endothelium of an arterial wall, especially repeated injury caused by infection, trauma, or hypertension, results in an inflammatory reaction, eventually leading to the development of an atheroma.
_____ has been positively associated with the rate of development and severity of atherosclerosis
hypercholesterolemia
Why do smoking and hypertension have increased risks of atherosclerosis?
because they cause vascular injury
What are two options for treating atherosclerosis surgically?
angioplasty and placement of a stent
bypass using a vein from elsewhere in the body
Where do aneurysms most occur?
arteries at the base of the brain or in the aorta
What is an aneurysm?
part of the arterial wall thins and balloons out
Capillaries connect _____ to _____
arterioles to venules
What is the average length and diameter of a capillary?
1mm in length
8-10 micrometers in diameter
Capillaries consist solely of a ____ and a _____
endothelial layer resting on a basement membrane
What are the three types of capillaries?
continuous, fenestrated, sinusoids
Describe a continuous capillary:
lining of endothelial cells is complete around the lumen; basement membrane is complete; intercellular clefts exist between endothelial cells
Describe a fenestrated capillary:
Same as continuous capillary except the cells contain fenestrations, or holes, ranging from 10 to 100 nanometers in diameter
Describe sinusoid capillary:
Lining of endothelial cells is incomplete around the lumen; basement membrane is incomplete or absent
What passes through a continuous capillary?
some leukocytes, plasma and its contents (except most proteins)
What passes through a fenestrated capillary?
Large amounts of materials are filtered, released or absorbed; some smaller proteins
What passes through a sinusoid capillary?
Large substances (formed elements, large plasma proteins, and plasma)
List some locations of continuous capillaries:
most capillaries are continuous
capillaries within muscles, skin, thymus, lungs, and central nervous system
List some locations of fenestrated capillaries:
small intestine for absorbing nutrients
ciliary process to produce aqueous humor
choroid plexus to produce cerebral spinal fluid in the brain
most endocrine glands, permit absorption of hormones into the blood
kidneys for filtering blood
List some locations of sinusoid capillaries:
bone marrow where formed elements enter the blood
liver and spleen where old erythrocytes are phagocytized by macrophages and taken out of circulation
some endocrine glands such as the anterior pituitary, adrenal, and parathyroid
What kind of junctions secure endothelial cells together in continuous capillaries?
tight junctions
The gaps between endothelial cells of continuous capillaries are called:
intercellular clefts
What can fit between intercellular clefts of continuous capillaries?
glucose, amino acids, ions
What is another name for sinusoid capillaries?
discontinuous capillaries
Define the blood brain barrier
modified continuous capillaries
have thickened basement membrane
no intercellular clefts
What is a capillary bed
a group of 10 to 100 capillaries functioning together
what feeds a capillary bed?
metarteriole, which is a branch of an arteriole
The _____ part of a metarteriole is encircled by smooth muscle cells, and the _____ part has no smooth muscle cells
proximal; distal
what is the distal part of a metarteriole called?
thoroughfare channel
Do thoroughfare channels have smooth muscle cells?
No
The thoroughfare channel of a capillary bed connects to a _______
postcapillary venule
True capillaries branch from the ______
thoroughfare channel
What regulates blood flow into true capillaries?
precapillary sphincters
This makes up the bulk of a capillary bed
true capillaries
precapillary sphincters go through cycles of contracting and relaxing at a rate of about 5 - 10 cycles per minute. This cyclical process is called _____
vasomotion
vasomotion
precapillary sphincters go through cycles of contracting and relaxing at a rate of about 5 - 10 cycles per minute.
the specific amount of blood entering capillaries per unit time per gram of tissue is called
perfusion
perfusion
the specific amount of blood entering capillaries per unit time per gram of tissue
perfusion is typically expressed ______
millimeters per minute per gram
mL/min/g
____ are the smallest veins
venules
what is the range of size of venules?
from 8-100 micrometers in diameter
venules are companion vessels with _____
arterioles
What are the smallest venules?
postcapillary venules
What drains capillaries?
post capillary venules
do any venules have all three tunics?
yes, the largest do
What merges to form veins?
venules
a venule becomes a vein when its diameter is greater than ______ micrometers
100
small and medium-sized veins are companion vessels with ______
muscular arteries
the largest veins are companion vessels with _____
elastic arteries
Is blood pressure in veins high enough to overcome the forces of gravity?
no
What characteristic do veins have that prevent blood from pooling in the limbs?
valves
Vein valves are formed primarily by ____ and strengthened by ______
tunica intima
elastic and collagen fibers
Valves have an anatomic structure similar to ______
semilunar valves of the heart
What are the percentages of blood in the pulmonary, cardiac, systemic circulation at rest?
pulmonary = 18%
heart = 12%
systemic circulation = 70%
about 55% of systemic is in veins
about 10% of systemic is in arteries
about 5% in capillaries
A modified vein that has very thin walls and no smooth muscle is referred to as a _____
sinus
What is a sinus?
a modified vein that has very thin walls and no smooth muscle
What are two examples of sinuses?
coronary sinus and dural venous sinuses
How does a vein serve as a blood reservoir?
Vasoconstriction moves blood from the veins and into other parts of the circulation. Vasodilation of veins allows it to flow back into the veins as reserves
What are the two ways blood vessels are arranged?
simple pathway
alternative pathway
_____ use one major artery, one capillary bed, and one major vein to deliver blood to a body region
simple pathways
Define simple pathways
use one major artery, one capillary bed, and one major vein to deliver blood to a body region
What two kinds of alternative pathways are there?
anastomoses and portal systems
Give an example of an organ with a simple pathway
spleen
the splenic artery delivers oxygenated blood to the spleen with the exchange made in a capillary bed of the spleen, and a single splenic vein drains deoxygenated blood from the spleen
Arteries that provide only one pathway through which blood can reach an organ are referred to as _____
end arteries
What are end arteries?
Arteries that provide only one pathway through which blood can reach an organ
What is the function of capillaries?
To allow for the exchange of substances such as respiratory gases, nutrients, wastes, and hormones between the blood and the surrounding tissues
What are three exchange processes at capillaries?
diffusion, vesicular transport, and bulk flow
What substances are transported by diffusion through the capillaries?
glucose, ions, oxygen, carbon dioxide
What substances leave the capillaries by vesicular transport?
insulin, fatty acids
What is vesicular transport?
endothelial cells use pinocytosis to fuse fluid-filled vesicles with the plasma membrane and transport their contents to and from blood and interstitial fluids
What is bulk flow?
the movement of large amounts of fluids and their dissolved substances in one direction down a pressure gradient
Filtration is a process that occurs at the _____ end of a capillary
arterial
_____ is the bulk flow of movement at the arterial end of a capillary through fenestrations or between intercellular clefts.
Filtration
_____ is the opposite of filtration and occurs at the _____ end of the capillary
reabsorption; venous
What are the two types of pressures at a capillary?
hydrostatic in the blood and hydrostatic at the tissues
What is BCOP?
is it an inward or outward force?
blood colloid osmotic pressure
inward
What is the outward force in bulk transport?
Inward?
blood hydrostatic pressure
blood colloid osmotic pressure
What is the formula for net hydrostatic pressure?
blood hydrostatic pressure in blood minus blood hydrostatic pressure in interstitial tissues
What is the formula for net blood colloid osmotic pressure?
colloid osmotic pressure in the blood minus colloid osmotic pressure in the interstitial tissues
How do you calculate net filtration pressure at a capillary during bulk flow?
(HPblood - HPif)-(COPblood-COPif) = NFP
(35-0) - (26 - 5) = NFP
35 - 21 = 14 mmHg arterial end
Define hydrostatic pressure
the physical force exerted by a fluid on a structure
blood hydrostatic pressure (blood pressure) is the force exerted per unit area by the blood as it presses against the vessel wall
______ promotes filtration from a capillary
blood hydrostatic pressure
This is the force of the interstitial fluid on the external surface of the blood vessel
interstitial fluid hydrostatic pressure
What are the two forces regulating filtration and absorption at the capillary?
hydrostatic pressure and colloid osmotic pressure
Does osmosis push or pull water?
pulls due to higher relative concentration of solutes
_____ refers to the pull of water back into a tissue by the tissue's concentration of proteins (colloid)
colloid osmotic pressure (COP)
_____ is the force that draws fluid back into the blood due to the proteins in the blood, such as albumin
blood colloid osmotic pressure
______ opposes hydrostatic pressure
blood colloid osmotic pressure
What is another term for blood colloid osmotic pressure?
oncotic pressure
what is another name for oncotic pressure?
blood colloid osmotic pressure
The NFP equation is a variation of ______
Starling's Law
What are the typical figures at an arterial end and venous end of a capillary?
Arterial:
HPb = 35
HPif = 0
BCOPb = 26
BCOPif = 5 NFP: 14mmHg
Venous:
HPb = 16
HPif = 0
BCOPb = 26
BCOPif = 5 NFP: 5mmHg
Is it possible for blood pressure to decrease to such a degree that capillary exchange ceases? Explain
Yes
Not enough volume to facilitate pressure for filtration
What are the three factors determining the amount of blood delivered to a specific organ or tissue?
1 - the degree of vascularization of the tissue
2 - local regulatory factors that alter blood flow
3 - total blood flow
______ determines the potential ability of blood delivery
degree of vascularization
The amount of vascularization in a given tissue may change over time through _____
angiogenesis
_____ is the formation of new blood vessels in tissues that require them
angiogenesis
When does angiogenesis occur?
weight gain, aerobic exercise, in response to occlusions etc
What is regression?
The opposite of angiogenesis
Formation of blood vessels within a tumor
tumor angiogenesis
_____ is the process by which a tissue itself regulates or controls its local blood flow in response to its changing metabolic needs
autoregulation
There is a negative feedback loop between elevated levels of ____, ____, ____, and ____, which act as vasodilators.
K+, H+, carbon dioxide, lactic acid
After temporary disruption in blood flow is returned and blood flow is restored, the marked increase in blood flow to the affected tissue is called _______
reactive hyperemia
_____ compensates for temporary lack of blood which is returned in order to get rid of the extra waste and bring extra nutrients
reactive hyperemia
When you return to a warm area after being in the cold and your cheeks are red is an example of
reactive hyperemia
These two vasochemicals are released in response to tissue trauma
histamine and bradykinin
_____ is a very powerful but short-lived vasodilator released from endothelial cells
nitric oxide
_____ is the amount of blood transported throughout the entire vasculature in a given period of time
total blood flow
_____ = cardiac output (term)
total blood flow
What is the average cardiac output?
5.25 L/min
Define blood pressure
the force per unit area that blood exerts against the inside wall of a vessel
A _____ is the change in blood pressure from one end of a blood vessel to its other end
blood pressure gradient
systolic pressure - diastolic pressure = _____
pulse pressure
systolic pressure occurs during ventricular _____ and diastolic pressure occurs during ventricular _____
contraction; relaxation
_____ is the additional pressure placed on the artery from when the heart is relaxing to when it is contracting
pulse pressure
What are the two values that can be calculated from systolic pressure and diastolic pressure?
pulse pressure and mean arterial pressure
A possible consequence of an elevated MAP is _____
cerebral edema
Why does excess fluid remain in the interstitial fluids at the brain?
there are no lymph vessels to help drain it
MAP
mean arterial pressure
average measure of the blood pressure forces on the arteries
MAP = Diastolic pressure + 1/3pulse pressure
DVT
deep vein thrombosis
blood clot (thrombus) in the vein
The most serious complication of a DVT
pulmonary embolus
Is there a pulse pressure at capillaries?
No, blood flow is smooth and even at the capillaries
Is there a blood pressure in venules?
No. Too far from the heart and not influenced by the pumping action of the heart
Two ways venous return is aided to overcome low pressure:
skeletal muscle pump within the limbs and respiratory pump within the torso (inhalation causes muscles to contract in the abdomen around the IVC)
What causes vericose veins?
Valves in the veins have become nonfunctional causing pooling and the veins to swell and bulge
_____ is the amount of friction the blood experiences
resistance
______ is resistance in blood vessels
peripheral resistance
What increases peripheral resistance?
viscosity, length of vessels; vessel radius
the difference in flow rate within a blood vessel is called _____
laminar flow
The relationship between blood flow and radius
F (is proportional to) r^4
in mm/sec
vasoconstriction and vasodilation of arterioles is controlled how?
systemically by the sympathetic division of the ANS
Mathematically express the relationship of blood pressure gradients and resistance:
F (is proportional to) delta P/resistance
delta P = P1-P2 (pressure gradient)
Is blood flow inversely or directly related to resistance?
inversely
if resistance goes up, blood flow goes down
Blood pressure is dependent on three primary variables:
cardiac output, resistance, and blood volume
The cardiovascular center in the medulla oblongata receives signals from _____ and _____ in the _____ and the _____
chemoreceptors; baroreceptors; aortic arch; carotid arteries
How does the cardiovascular center regulate blood pressure?
through motor output from sympathetic nerves and vagus nerves by adjusting cardiac output and peripheral resistance experienced by blood in blood vessels
What are the three sub-centers of the cardiovascular center
cardioacceleratory center;
cardioinhibitory center
vasomotor center
vessels innervated by _____ fibers vasoconstrict
adrenergic
vessels innvervated by ______ fibers vasodilate
cholinergic
carotid and aortic bodies contain _____
chemoreceptors
where are baroreceptors?
aortic arch and carotid sinus of external carotid
The _____ regulates heart activity and thus cardiac output
cardiac center
The _____ controls the degree of vasoconstriction of blood vessels and thus regulates resistance
vasomotor center
sympathetic division pathways extend from the cardioacceleratory center to ______ and _____
SA node; myocardium
Increased sympathetic output from the cardioacceleratory center does what?
increases heart rate and force of contraction, increasing cardiac output
Parasympathetic division pathways extend from the cardioinhibitory center to _____ and _____
SA node; AV node
Increased parashympathetic motor output from the cardioinhibitory center does what?
decreases heart rate and slows the conduction of electrical signals through the heart's conducting system, decreasing cardiac output
vasomotor center:
sympathetic division pathways extend from the _____ to ______
vasomotor center to the blood vessels
What are the two primary receptors associated with the smooth muscle within the wall of vessels?
alpha (a) receptors
beta (B) receptors
Blood vessels containing a receptors _____ in response to sympathetic stimulation
what vessels have alpha receptors?
contract
most vessels of the body
blood vessels containing B receptors ______ in response to epinephrine (sympathetic) stimulation
What vessels have beta receptors?
relax
vasodilation
skeletal muscle and coronary vessels
Activation of the vasomotor center and increased nerve signals along sympathetic pathways cause ___, ___, and ___
increased peripheral resistance
larger circulating blood volume
redistribution of blood flow
_____ are specialized sensory nerve endings that respond to the stretch in blood vessel walls
baroreceptors
Where are the aortic arch and carotid sinus baroreceptors located
tunica externa of the aortic arch
tunica externa of each internal carotid artery
What nerve sends signals from aortic arch baroreceptors to the cardiovascular center?
vagus nerve CNX
the aortic arch transmits signals to the brain via _____ and the carotid sinuses transmit signals to the brain via _____
vagus nerve CNX
glossopharyngeal nerve IX
baroreceptors activate and initiate _____
baroreceptor reflexes
____ is chronically elevated blood pressure
hypertension
_____ is chronically low blood pressure
hypotension
_____ is a drop in blood pressure when a person suddenly changes position
orthostatic hypotension
primary function of chemoreceptors; secondary?
regulating respiration
regulating bp
result of chemoreceptor stimulation
chemoreceptor reflexes
The two main peripheral chemorecptors are:
aortic bodies; carotid body
chemoreceptors primarily stimulates _____
vasomotor centers
The _____ alters blood pressure in response to emotion
limbic center
What hormones participate in regulating hormones?
epinephrine and norepinephrine
angiotensin II
antidiuretic hormone
aldosterone
atrial natriuretic peptide
This straddles short-term neural bp regulation and long-term hormonal regulation
renin-angiotensin system
what hormone is associated with the renin-angiotensin system?
angiotensin II
Why is angiotensin II involved in both neural and hormonal bp regulation?
it is initiated by the nervous system and it causes the release of other long term hormones
_____ is an inactive hormone produced by the liver and secreted into the blood. It is converted to ______ by ____, an enzyme released by the kidney in response to low BP at the kidney. It is then converted to ______ by ______, which is an enzyme associated with the capillary endothelium (mostly in the lungs)
angiotensinogen
angiotensin I; renin
angiotensin II; angiotensin-converting enzyme (ACE)
What three things does angiotensin II do to increase blood pressure?
causes vasoconstriction
stimulates the thirst center
decreases urnin formation
When is aldosterone released? From where? What does it do?
Released from the adrenal cortex in response to angiotensin II. It increases absorption of NA+ and water in the kidney, decreasing their loss in the urine.
_____ is released from the atrium of the heart in response to increase blood volume
atrial natriuretic peptide
What is the net effect of the release of ANP?
How?
decrease in blood pressure
ANP stimulates vasodilation, which decreases resistance and increases urine output, which decreases blood volume
Three primary factors influence blood pressure:
cardiac output, peripheral resistance and blood volume
The rate of blood transported per unit time
blood flow velocity
What is the pulmonary circulation responsible for?
carrying deoxygenated blood from the R heart to the lungs then returning oxygenated blood to the L heart