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106 Cards in this Set
- Front
- Back
Chromosome
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Strand of DNA associated with many proteins and thousands of genes
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Fluid Mosaic Model
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Sea of fluid lipids containing mosaic of proteins
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Lipid Bilayer Composition?
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-75% Phospholipid
-20% Cholesterol -5% Glycolipid |
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Amphipathic
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Having both polar and nonpolar ends
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Each lipid has 2 _______
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non polar fatty acid tails
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Integral Proteins (3)
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-Mostly Transmembrane proteins
-Tightly Embedded -Amphipathic |
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Peripheral Proteins (2)
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-Loosely Embedded
-Dwell at inner or outer surface |
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GlycoProteins (1)
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Has Carbohydrate Groups attached at the ends
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Carbohydrates of GlycoProteins (2)
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-Called Oligosaccharides
-Has Glycocalyx which allows for cell recognition |
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Ion Channels
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Pores that allow passing of specific Ion
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Transporters
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Moves Polar substances in or out of cell
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Receptors
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Recognition sites for specific molecules
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Ligand
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Specific molecule that binds to Receptor Protein
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Linkers
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Anchors proteins into other cells
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Functions of GlycoProteins & Glycolipids
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- Cell ID Marker to mark neighboring cells or dangerous cells
i.e ABO blood cell marker |
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Functions of Peripheral Proteins (3)
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-Supports plasma Membrane
-Moves materials In & Out -Changes cell shape |
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Membrane Fluidity Factors
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- Number of Double Bonds in fatty acid
- Amount of Cholesterol |
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Effect of more double bonds in Fatty Acid Tails
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More Fluid due to reduced packing
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Effect of Cholesterol on Membrane Fluidity
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Higher temp - Less Fluid
Lower temp - More Fluid |
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Membrane Permeable Molecules
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O2
N2 CO2 Steroids Vitamins AEDK Small Alcohols NH3 |
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Non Membrane Permeable
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K+
Na+ Cl- H+ Glucose |
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Semi Membrane Permeable
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Water & Urea
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More Na+ & O2
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Concentrated Outside the Cell
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More K+ and CO2
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Concentrated inside the cell
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Charge of Inner membrane
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Negative Charge of Membrane
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Charge of Outer Membrane
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Positive Charge of Membrane
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Electrical Gradient
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Electrical Difference across Plasma Membrane
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Membrane Potential
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Potential energy of Ions across Membrane
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ElectroChemical Gradient
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Membrane potential on one particular Ion
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Factors on Speed of Passive Diffusion
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-Surface Area
-Diffusion Distance -Steepness of Concentration -Temperature |
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Aquaporins
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Membrane protein for Water
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Hydrostatic Pressure
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Pressure of water on membrane of Higher side
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Lysis
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Bursting of cell when placed in Hypotonic Solution
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Crenation
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Shrinking of cell when placed in a Hypertonic Solution
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Facilitated Diffusion
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Solute Binds & is released on other side once Transporter changes shape
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Transport Maximum
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When Facilitated transport has reached saturation
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Energy expense of Primary Active Transport
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40% of cellular energy is used
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Trigger of Sodium Potassium Pump
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Phosphate group from ATP
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Secondary Active transport
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Uses Electrochemical Gradient to transport other substances
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Symporters
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Transports 2 substances to the same side
i.e Na+&Glucose Na+&Amino Acid |
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Antiporters
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Transports 2 substances to opposite side
i.e Na+&H+ Na+&Ca2+ |
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Endocytosis
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Movement of Material into a cell via Vesicle
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Exocytosis
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Movement of Material out of cell via Vesicle
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Clatherin
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Protein used to fold vescicle
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Phagocytosis
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Form of endocytosis where cell engulfs a large solid particle
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Phagocytes
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Large Eater Cells
i.e MacroPhages & nutrophils |
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Pseudopods
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Projections of Cellular membrane to form phagosome
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Phagosome
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A type of vesicle used formed by pseudopods
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Pinocytosis
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When drop of ECF enters and pinches off
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Types of cells that rely on exocytosis (2)
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- Secretory Cells releasing Digestive enzymes, mucus, hormones etc
- Nerve cells releasing neurotransmitters |
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Transcytosis
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Endocytosis on one side then Exocytosis on the other side
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Components of Cytoskeloton
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Microfilament
Intermediate Filament Micro Tubule |
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Makes Microfilament
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Actin
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Makes Micro Tubule
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Tubulin
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Centrosome
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Creates mitotic Spindles during Mitosis
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Cilia
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Moves fluid along cell surface
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Flagella
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Moves the entire cell
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Ribosome components and purpose
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-RNA and ribosomal proteins
-Protein Synthesis |
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Rough ER
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Studded with ribosomes for protein synthesis
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Smooth ER (3)
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-Lacks ribosomes
-Synthesizes fatty acids and steroids -Detoxifies drugs |
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Golgi
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-Consists of Cisternae
-modify, sort, and pack proteins for vesicles |
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Lysosome
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Membrane enclosed organelle that contains digestive enzymes
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Autophagy
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Digestion of worn out organelles
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Autolysis
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Digestion of host cell
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Peroxisome
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Contains Oxidases that oxidize amino acids, fatty acids, and toxic substances
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Proteasome
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Contains Protease to break down faulty proteins
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Mitochondria
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Consists of outer membrane and inner membrane called cristae
Generates cellular ATP |
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Nucleoli
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Porduces Ribosomes
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Genome
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Total genetic information carried in an organism
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Nucleosome
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Bead consisting of Double strand DNA wrapped twice around a Histone
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Histone
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Core of 8 proteins in a Nucleosome which helps to organize folding of DNA
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Linker DNA
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DNA between nucleosomes
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Proteome
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All of an organism's proteins
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Base triplet
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Genetic information of DNA and RNA in sets of 3s
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Codon
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Complementary sequence of a Base Triplet
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Genetic Code
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Set of rules that relate the base triplet sequence of DNA to corresponding codons
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mRNA
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Directs synthesis of Protein
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rRna
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Joins with ribosomal proteins to make ribosomes
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tRNA
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binds to an amino acid and holds it in place on a ribosome until its incorporated into a protein
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Anticodon
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Nucleotide triplet on other side of tRNA
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RNA Polymerase
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Catalyzes transcription
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Promoter
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Special nucleotide sequence located to show beginning of a gene.
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Terminator
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Special nucleotide sequence signaling end of gene
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Introns
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Regions within a gene that DOES NOT code for proteins
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Exons
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Regions within a gene that DOES code for proteins
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pre-mRNA
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the mRNA with both introns and exons
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Small Nuclear ribonucleoproteins
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Removes Introns from pre-mRNA, then passes mRNA through nuclear pore
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Alternative Splicing of mRNA
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Process where pre-mRNA is spliced in different ways to produce many different mRNAs
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Somatic Cell
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Any cell of the body besides a Germ cell
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Homologous Chromosomes
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The two chromosomes that make up a pair.
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Interphase
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Consists of G1, S and G2 phases
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G1 Phase
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Phase where cell duplicates organelles and centrosomes
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S phase
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Phase where Cell is committed to Replicate and DNA replication takes place
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G2 Phase
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Phase where proteins and enzymes are synthesized and centrosome replication is complete
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G0 Phase
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Cells that are in G1 for too long and are destined to never divide again
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Prophase (2)
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-Phase where Chromatin fibers condense and become visible.
-Mitotic spindle forms |
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Centromere
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Constricted region that holds chromatid pairs together
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Kinetochore
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Protein complex outside of each centromere
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Metaphase
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Phase where Microtubules align centromeres at center called Metaphase Plate
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Anaphase
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Phase where Centromeres are pulled apart by Mitotic spindle and are now chromasomes
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Telophase
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Final stage of mitosis when mitotic spindle breaks up
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Cytokinesis (2)
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-Division of cell's cytoplasm and organells
-Formation of Cleavage Furrow |
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Aptosis
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Genetically programmed death for a cell
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Necrosis
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Pathological type of cell death
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Synapsis
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Crossing over of Genes
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Telomeres
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DNA sequences found at tips of chromosomes, shortened after each division, causing aging and death
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