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15 Cards in this Set

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dec. in red blood cells-leads to inability to transport oxygen
Average blood volume of an adult?
=about 5 liters or 8% body wt.
Plasma=55% by vol.
(Blood Composition)
-H2O, amino acids, proteins, carbohydrates, lipids, vitamins, hormones, electrolytes, cellular wastes
Formed Elements+45% by col.
(Blood Composition)
-Erythrocytes (RBC'S)=99% of Packed cell volume(PCV)
-Leucocytes (WBC's) is less than or = to 1%
The process through which Hemocytoblasts(stem cells) mature into all blood cell types & platelets
function of Biconcave discs(breathsaver)
(f) surface area for diffusion, allows folding
=33% by vol: Hemoglobin
-what's its function?
to bond w/oxygen to yield oxyhemoglobin(bright red blood)
Path note
low blood oxygen(hypoxia), will inc. deoxyhemoglbin turning skin & mucous membranes blue (cyanosis)
path note-what causes cyanosis?
e.g, suffocation, poisonous gases, vasoconstriction of surface vessels due to cold.
why do mature RBC's lack nuclei?
f: inc. space for hemoglobin
Lack of Nuclei results in:
a. no mitosis in mature RBC's
b. no mitochondria-only glycolysis possible
P.N-Sickle cell disease
an incorrect amino acid causes hemoglobin to sickle causing damming in small capillaries-tissue hypoxia
production of red blood cells for several days
-life span=120 days
Action of erythropoietin
stimulates red marrow to produce & release RBC"s into circulation (chart pg 560)
Destruction of RBC"s
1. damage/destruction occurs in capillaries
2. damaged RBC's rupture in spleen & liver. components
phagocytized by macrophages
3. hemoglobin components recycled
A. 4 polypeptide globin chains
B. 4 heme groups