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19 Cards in this Set
- Front
- Back
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Receptor Mechanism of Benzodiazepines
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Modulate GABA receptor allosterically.
Increase Cl- relative to GABA concentration. Increase Frequency of channel openings. REQUIRES Gamma subunit. |
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Receptor Mechanism of Barbiturates
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Modulate GABA receptor allosterically.
Increase Cl- independently to GABA concentration. Increase Prolongation of open channels. Does NOT REQUIRE a Gamma subunit. |
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Clonidine
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Autonomic Anxiolytic
Alpha-2 Agonist Tx for situational phobias. |
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Buspirone
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Unique dual mechanism as Serotonin and Dopamine Agonist.
Minimal sedation, no tolerance/dependence. Tx. for generalized anxiety. |
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Phenobarbital
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Long acting Barbiturate.
Most frequently used. (P-PAST: Pentobarbital, Phenobarbital, Amobarbital, Secobarbitual, Thiobarbitual) |
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Amobarbital
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Barbiturate
Anxiolytic use. (P-PAST: Pentobarbital, Phenobarbital, Amobarbital, Secobarbitual, Thiobarbitual) |
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Pentobarbital
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Intermediate Barbiturate.
Anxiolytic use. (P-PAST: Pentobarbital, Phenobarbital, Amobarbital, Secobarbitual, Thiobarbitual) |
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Secobarbitual
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Short acting barbiturate.
Anxiolytic (P-PAST: Pentobarbital, Phenobarbital, Amobarbital, Secobarbitual, Thiobarbitual.) |
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Adverse Effects: Barbiturates
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1. General: Dizzy, weakness, visual disturbances, Respiratory and Cardiac Depression, Coma. = SMALL MARGIN OF ERROR
2. Abuse Potential: Dependence, Withdrawal, Tolerance (P-PAST: Pentobarbital, Phenobarbital, Amobarbital, Secobarbitual, Thiobarbitual.) |
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Pharmoacokinetics: Benzodiazepines
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Anti-Anxiety
High Plasma Binding Hepatic Metabolism Phase 1: p450 Cytochrom Oxidase Phase 2: Glucoroonidation Enterohepatic Recirculation and thus Rebound of drug. |
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Adverse Effects: Benzodiazepines
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Sedation (more in elderly)
Rebound Anxiety Withdrawal Syndrome with abrupt termination of therapy. |
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Thiopentate
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Ultra Short acting barbiturate.
Used in anesthesia. (P-PAST: Pentobarbital, Phenobarbital, Amobarbital, Secobarbitual, Thiobarbitual.) |
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Alprazolan
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Anxiolytic/Anti-Anxiety
Benzadiazepine - GABA/Beta2 Receptor Agonists Top 5 Anti-Anxiety Drug (C-LOAD) |
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Diazepam
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Anxiolytic/Anti-Anxiety
Benzadiazepine - GABA/Beta2 Receptor Agonists Top 5 Anti-Anxiety Drug (C-LOAD) |
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Lorazepram
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Anxiolytic/Anti-Anxiety
Benzadiazepine - GABA/Beta2 Receptor Agonists Top 5 Anti-Anxiety Drug No active metabolite. (C-LOAD) |
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Oxazepram
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Anxiolytic/Anti-Anxiety
Benzadiazepine - GABA/Beta2 Receptor Agonists Top 5 Anti-Anxiety Drug No active metabolite. (C-LOAD) |
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Clonazepam
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Anxiolytic/Anti-Anxiety
Benzadiazepine - GABA/Beta2 Receptor Agonists Top 5 Anti-Anxiety Drug (C-LOAD) |
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Propranolol
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Anxiolytic/Beta Blocker
Beta-adrenergic Receptors (PA) Remember some Dads need Beta blockers for heart and anxiety. |
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Atenolol
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Anxiolytic/Beta Blocker
Beta-adrenergic Receptors (PA) Remember some Dads need Beta blockers for heart and anxiety. |
