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17 Cards in this Set

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Zolpidem (Ambien)***
GABAa Non-BZ Sedaive

Biphasic release (1st --> sleep; 2nd --> stay asleep)

No hangover next day
Zaleplon (Sonata)***
Selective based on binding to a1-subunit

Optimal drug for pt walking in the middle of the night

Short t1/2 (1.4hr) so great for those who wake up & can't go back to sleep (out of your system before am)

Limited hangover next am
Mirtazapine (Remeron)
H1 blocker for depression

ALSO can help pt fall asleep & inc appetite

(little old lady whose husband died)
Flumazenil (Romazicon)***
BZ antag

Can cause seizure in pt on TCA

Will get w/drawal in BZ-dependent pt
Escitalopram (Lexapro)***
SSRI of choice
Fluoxetine (Prozac)***
AVOID.

Long t1/2 (6d) so wash out time is SLOW (>1mo) & has a ton of drug interactions. (inc risk of serotonin syndrome)
Serotonin Syndrome***
Mental status changes
Autonomic instability
NM aberrations
GI sx

Diff from neuroleptic malignant syndrome -- no muscule rigidity or CPK elevation

Tx: BZ + Cyproheptadine
Fentanyl (Duragesic)
Opiod anesthetic (&analgesia)

SE: constipation & resp depression

DOC of anesthesiologist addiciton
Propofol
PO GABA pre-anesthetic

Euphoria is unbelievable (high abuse)

Induces & maintains day surgery
Rapid recovery
Blocks broncoconstriction
CV & resp depression
Xanax
Tx pain d/o through GABA BZ anxiolytic effect

Addictive!
Baclofen
TX for EtOH therapy

GABAb Ag
Vigabatrin
GABA transaminas-I

TX for inhalent abuse
Valium
GABAa BZ anxiolytic

Blocks resp. depression
No synergy w/ EtOH
DOC IV for status epilepticus
Sonata
Non-BZ

For pt who wake up in the night

Short t1/2
Prazosin
A1 blocker

PTSD night mare TX
Klonopin
GABAa BZ anxiolytic

BZ OF CHOICE for anxiety
--give short term w/ SSRI
Lorazepam (Ativan)
TX aggressive pt in ER