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18 Cards in this Set
- Front
- Back
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ostelamivir zanamivir |
block influenza neuramidase to block release of progeny virus -good for influenza A and B |
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Acyclovir Famciclovir (Herpes zoster) Valacyclovir (best oral availability) |
Guanosine analogs that get phosphorylated by viral thymidine kinase, then cellular enzymes add more phosphates. This blocks viral DNA polymerase -treat HSV and VZV -will not affect latent HSV and VZV -s/e: acute renal failure |
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Ganciclovir
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guanosine analog. Gets phosphorylated by CMV viral kinase, then by cellular kinases to block viral DNA polymerase Tx: CMV s/e: BM suppression , renal toxicity |
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Foscarnet
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Doesn't give a "fosc". This is a pyrophosphate analog. -does not need TK. Just binds to pyrophosphate binding site of DNA polymerase and blocks it. Also blocks HIV RT. Tx: Second line after other viral inhibitors fail. CMV retinitis if ganciclovir fails. HSV if acyclovir fails s/e: nephrotoxic-->> low k, low mg, high Po3-->seizures |
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Cidofovir
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cytosine analog that is already a nucleotide so it does not need to be phosphorylated. Blocks viral DNA polymerase Tx: 2nd line after viral inhibitors fail. CMV retinitis, acyclovir resistant HSV s/e: nephrotoxic |
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Abacavir (not for HLA-B 5701) Didanosine (pancreatitis= s/e) Emtricitabine FTC Lamivudine 3TC Stavudine Tenofovir (nucleotide) Zidovudine ZDZ (AZT) GOOD FOR PREGNANCY |
NRTI for HIV Moa: These are nucleosides. Must be phosphorylated by viral thymidine kinase. Block nucleotide binding to RT, terminate DNA chain because they lack an 3'OH S/e: BM suppression unless you give G-CSF and EPO too S/e: peripheral neuropathy, lactic acidosis, anemia, pancreatitis |
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DElavirdine Efavirenz (X PREGNANCY) Nevirapine (X PREGNANCY) |
NNRTI for HIV MOa: Bind to RT without needing to be phosphorylated first. s/e: rash, liver tox, super vivid dreams with efavirenz!!!!!! |
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Atazanavir Darunavir Fosa,prenavir Indinavir Lopinavir Ritonavir (blocks P450) Saquinavir |
Protease inhibitors for HIV MOA: HIV-1 protease (pol gene) cleaves HIV mRNA into functional unites. No protease? No new virus because the they cannot "mature". s/e: HYPERGLYCEMIA, lipid dystrophy ( loss of fat from face and extremities, extra fat in central body), nephropathy Note that rifampin should not be used with "navirs" bc rifampin induces CYP/UGT, which would decrease protease inhibitor concentration |
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Raltegravir Elvitegravir Dolutegravir |
Integrase inhibitors. Moa: Block HIV genome integration into host. They reversibly inhibit HIV integrase so eventually, viral mRNA is reduced in the cell. s/e: Myopathy |
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Enfuviritide
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Binds gp41 so virus cannot fuse with host cell
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Maraviroc
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Binds CCR5 on TC. This blocks gp120 from interacting with CCR5
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Which interferon would you give for Hep B, Hep C, kaposki sarcoma, Hairy cell leukemia, condylomata acuminatum, renal cell carcinoma, and malignant melanoma?
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IFN-a
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Which interferon for multiple sclerosis?
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IFN B
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Which INterferon for chronic granulomatous disease?
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IFN- y
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Ribavirin
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Hep C therapy, RSV -inhibits IMP dehydrogenase so cell cannot make new guanine nucleotides |
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Sofosbuvir
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Hep C therapy, inhibits HCV RNA-dep RNA pol and terminates the chain ** use with ribavirin, which blocks IMP DH |
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Simepravir
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Hep C therapy -blocks HCV protease -s/e: photosensitivity and rash
** use with ledipasvir, which blocks NS5a |
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Amantidine/rimantidine
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Block influenza from uncoating but are no longer used due to resistance
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