Antivirals

Front 1

amantidine, ramantidine

Back 1

intefere w/ m2 protin channel in viral envelope

no H+ in, no dissociation of matrix protein

for influenza A

Front 2

oseltamivir aka tamiflu

Back 2

release inhibitor

for influenza A and B

inhibits neuramidase (cleaves sialic acid and relesaes viron). so no release of viron

can be taken prophylatically

Front 3

acyclovir

Back 3

herpes

acyclovir triphosphate attaches to viral DNA and messes up DNA elongation by viral polymerase

Front 4

valcyclovir

Back 4

same as acyclovir

5x better oral bioavailability tho

Front 5

famciclovir, penciclovir

Back 5

famciclovir = 70% bioavail
penciclovir ointment = cold sores on skin

Front 6

gancyclovir

Back 6

cytomegalovirus

less specificity than acyclovir so increase AE

Front 7

lamivudine

Back 7

anti hepatitis B medication + HIV

inhibits viral repolication because inhibits reverse transcriptase

suppression maintained for 2 yrs

Front 8

zidovudine (AZT)

Back 8

inhibits reverse transcriptase of HIV virus

incorporation and chain termination

Front 9

emtricitabine (FTC)

Back 9

advantage: once a day

nucleoside analog...inhibits RNA polymerase

Front 10

foscarnet (PFA)

Back 10

DNA + RNA polymerase inhibitors by mimiciking pyrophosphate
for HIV, CMV, HSV

problem: lacks oral bioavail.

Front 11

protease inhibitors

Back 11

ritonavir, nelfinavir, saquinavir
"-avir"

mimics peptides and binds to protease and halts it irreversibly

produces non-infectious viruses since they can't make use of the proteins

Front 12

enfuvirtide

Back 12

HIV viral fusion inhibitor. stops entrance into tell

Front 13

ribavirin

Back 13

looks like purine. works on RNA viruses and inhibits virus (MOA not clear)