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15 Cards in this Set

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  • Back
What are the two drugs that only work against influenza A?
Amantadine and Rimantadine
How do Amantadine and Rimantadine work?
They block the M2 ion channel, which keeps the virus from getting acidified and fusing with the host phagolysosomal membrane
How does influenza A develop resistance to Amantadine and Rimantadine?
Alteration in the protein that keeps the drug from binding
How are Amantadine and Rimantadine administered?
Orally
How are Amantadine and Rimantadine excreted? What is there half life?
Renally
Amantadine = 15 hr (little metabolism)
Rimantadine = 30 hr (extensive metabolism)
What are the adverse effects of Amantadine and Rimantadine?
GI irritation
CNS effects (can be taken up by CSF)
What else is Amantadine used for?
Treatment of mild Parkinson's
What are the neuraminidase inhibitors?
Zanamivir and Oseltamivir
What do Zanamivir and Oseltamivir act against?
Influenza A and B
How do Zanamivir and Oseltamivir work?
They inhibit neuraminidase, which cleaves newly created virus from the surface of the cell it is leaving. Inhibition keeps the virus from leaving the cell
What cell structure do Zanamivir and Oseltamivir mimic?
Sialic acid
What is the mechanism of virus resistance to Zanamivir and Oseltamivir?
Mutation in neuraminidase that decreases affinity of drug for enzyme
How are Zanamivir and Oseltamivir administered?
Zanamivir - inhalant
Oseltamivir - oral
What are the adverse effects of Zanamivir and Oseltamivir?
Zanamivir - bronchospasm or decline in lung function in patients with pre-existing respiratory disease
Oseltamivir - GI irritation
What are the clinical uses of Zanamivir and Oseltamivir?
Prevention and treatment of influenza A and B (treatment can shorten the course of the disease by 1-2 days)