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19 Cards in this Set
- Front
- Back
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acyclovir
Zovirax |
= herpes simplex virus treatment
indications: herpes zoster (shingles), genital herpes (HSV2), chicken pox (varicella) ORAL =nucleoside analog so inhibits DNA polymerase side effects: well tolerated, commonly used in immunocompromised patients |
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cidofovir
Vistide |
= herpes simplex virus treatment
indications: for CMV retinitis ORAL -targets viral DNA polymerase side effects: nephrotoxicity when given IV |
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foscarnet sodium
Foscavir |
= herpes simplex virus treatment
indications: CMV retinitis, acyclovir-resistant HSV infections -NOT USED FOR HSV2 (genital) ORAL -targets viral DNA polymerase side effects: nephrotoxicity, hypocalcemia, seizures |
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ganciclovir
Cytovene |
= herpes simplex virus treatment
indications: SPECIFICALLY for CMV retinitis in immunocompromised patients, and CMV prevention in transplant patients ORAL toxicity: neutropenia, carcinogenic, TERATOGENIC |
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idoxuridine
Stoxil |
= herpes simplex virus treatment
indications: only for topical tx of HSV keratitis TOPICAL -targets DNA polymerase (thymidine analogue) |
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trifluiridine
Denavir |
= herpes simplex virus treatment
TOPICAL/DROPS indications: ONLY for keratoconjunctivitis and recurrent epithelial keratitis (HSV1 only) |
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amantadine
Symmetrel |
= influenza A treatment
ORAL indications: for tx and prevention of Influenza A in pts > 1 y.o. -blocks H+ migration through viral M2 channel to prevent uncoating side effects: CNS toxicity contraindication: is secreted, so beware renal insufficiency |
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rimantadine
Flumadine |
= influenza A treatment
indications: prevent influenza A in pts > 1 y.o., treats in pts > 13 y.o. ORAL -blocks H+ migration through viral M2 channel to prevent uncoating side effects: CNS side effects |
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zanamivir
Relenza |
= influenza A & B treatment
indications: tx A&B in patients > 7 y.o., prevent in pts > 5 y.o. INHALED -blocks neuraminidase so no viral release from host cell |
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oseltamivir
Tamiflu |
= influenza A & B treatment, H1N1 effective
indications: tx and prevent A&B > 1 y.o. ORAL -neuraminidase inhibitor so no viral release from host cell |
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adefovir
Hepsera |
= viral hepatitis treatment
indications: HBV, Lamivudin-resistant HBV infections, against hepadnavirus -nucleoside analog - blocks DNA polymerase and reverse transcriptase side effects: nephrotoxicity |
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lamivudin
Epivir |
= viral hepatitis treatment
indications: chronic HBV hepatitis -nucleoside analog, so blocks DNA polymerase and reverse transcriptase well-tolerated |
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ribavirin
Virazole, Rebetol |
= viral hepatitis treatment
indications: chronic HCV hepatitis, aerosol for RSV -inhibits DNA and RNA viral replication, blocks viral mRNA synthesis side effects: aerosol may cause conjunctival irritation, rash, wheezing |
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pegylated interferon (IFN)
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= viral hepatitis treatment
indications: chronic HCV and HBV infections, HPV (warts), Kaposi's sarcoma -activates PKR which phosphorylates eIF-2 to inhibit mRNA translation -activates GTPases to break down viral nucleocapsids -activates RNAases to break down nucleic acids "pegylated": bound to large molecule polyethelyne glycol; slows its absorption so levels remain high (dose x 1/week) side effects: flu-like sx, immunosuppression, bone marrow suppression, reduces hepatic CYP-metabolism of some drugs |
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famciclovir
Famvir |
= herpes simplex virus treatment
ORAL |
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penciclovir
Denavir |
= herpes simplex virus treatment
T, IV |
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fomivirsen
Vitravene |
= herpes simplex virus treatment
INTRAVITREAL |
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valacyclovir
Valtrex |
= herpes simplex virus treatment
ORAL |
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valganciclovir
Valcyte |
= herpes simplex virus treatment
ORAL |
