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34 Cards in this Set

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What is the prototypic drug for treating Herpes simplex virus and varicella-zoster virus?
Acyclovir
How does Acyclovir work?
Suppressing the synthesis of viral DNA
Pro-drug
What is Herpes Labialis?
Cold Sores
What are the adverse effects of IV acyclovir?
Reversible Nephrotoxicity
Phlebitis
Inflammation at the site of injection
What are the adverse effects of Valacyclovir?
Immunocompromised Patients:
Thrombic Thrombocytopenic purpura/ hemolytic uremic syndrome
What are the topical agents for herpes labialis?
Penciclovir
Docosanol
Acyclovir
Who is most likely to become ill by Cytomegalovirus (CMV)?
Immunocommpromised
How do all these antivirals work?
Pro-drug
Change into active form in the cell
Suppresses replication by inhibiting viral DNA polymerase and incorporation in the strand
What is the drug used against CMV?
Ganciclovir
What are the uses of Ganciclovir?
Prevention and Treatment of CMV
What are the adverse effects of Ganciclovir?
Bone marrow suppression
Tertogenic
What is the most effective treatment for Hepatitis C?
Pegylated Interferon alfa
Ribavirin
How is interferon alfa administered?
subQ
What are the long-term interferons called?
Peginterferon
How does interferon alfa work?
Human recombinant interferons
Multiple actions
What are the adverse effects of ribavirin?
Hemolytic Anemia
Category X
What are the adverse effects of interferon alfa?
Flu-like symptoms (diminish)
Neuropsychiatric effects
What is the best strategy against Hepatitis B?
Vaccination
What drugs are used for Hepatitis B?
Interferons 2b
How is influenza spread?
Aerosolized droplets produced by coughing or sneezing
Who can take the intranasal influenza vaccine?
People 5-49 years old
The influenza shot is ______ while the intranasal influenza vaccine is _____.
Inactivated
Live, attenuated
What is a rare complication of the influenza vaccine?
Guillain-Barre Syndrome
Severe, Paralytic Illness
What allergy is contraindicated for the influenza shot?
Hypersensitivity to eggs
What drugs are the adamantanes?
Amantadine
Rimantadine
What are the adamantanes effective against?
Influenza A
What are the adverse effects of amantadine?
CNS effects
Heart Failure
Category C
What is the prototypic neuraminidase inhibitor?
Oseltamivir
What is Oseltamivir effective against?
Influenza A and B
Oseltamivir treatment can begin at anytime in the course of the disease.
T or F
False
Treatment must start early
What drug is used to treat Respiratory Syncytial Virus?
Ribavirin
What drug is used to prevent RSV?
Palivizumab
What are the contraindications of Ribavirin?
Infants on ventilators
Lung deterioration
Category X
Does PO acyclovir and valacyclovir have serious adverse effects?
No