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34 Cards in this Set
- Front
- Back
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What is the prototypic drug for treating Herpes simplex virus and varicella-zoster virus?
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Acyclovir
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How does Acyclovir work?
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Suppressing the synthesis of viral DNA
Pro-drug |
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What is Herpes Labialis?
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Cold Sores
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What are the adverse effects of IV acyclovir?
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Reversible Nephrotoxicity
Phlebitis Inflammation at the site of injection |
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What are the adverse effects of Valacyclovir?
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Immunocompromised Patients:
Thrombic Thrombocytopenic purpura/ hemolytic uremic syndrome |
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What are the topical agents for herpes labialis?
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Penciclovir
Docosanol Acyclovir |
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Who is most likely to become ill by Cytomegalovirus (CMV)?
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Immunocommpromised
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How do all these antivirals work?
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Pro-drug
Change into active form in the cell Suppresses replication by inhibiting viral DNA polymerase and incorporation in the strand |
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What is the drug used against CMV?
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Ganciclovir
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What are the uses of Ganciclovir?
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Prevention and Treatment of CMV
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What are the adverse effects of Ganciclovir?
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Bone marrow suppression
Tertogenic |
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What is the most effective treatment for Hepatitis C?
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Pegylated Interferon alfa
Ribavirin |
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How is interferon alfa administered?
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subQ
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What are the long-term interferons called?
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Peginterferon
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How does interferon alfa work?
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Human recombinant interferons
Multiple actions |
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What are the adverse effects of ribavirin?
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Hemolytic Anemia
Category X |
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What are the adverse effects of interferon alfa?
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Flu-like symptoms (diminish)
Neuropsychiatric effects |
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What is the best strategy against Hepatitis B?
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Vaccination
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What drugs are used for Hepatitis B?
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Interferons 2b
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How is influenza spread?
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Aerosolized droplets produced by coughing or sneezing
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Who can take the intranasal influenza vaccine?
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People 5-49 years old
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The influenza shot is ______ while the intranasal influenza vaccine is _____.
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Inactivated
Live, attenuated |
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What is a rare complication of the influenza vaccine?
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Guillain-Barre Syndrome
Severe, Paralytic Illness |
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What allergy is contraindicated for the influenza shot?
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Hypersensitivity to eggs
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What drugs are the adamantanes?
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Amantadine
Rimantadine |
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What are the adamantanes effective against?
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Influenza A
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What are the adverse effects of amantadine?
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CNS effects
Heart Failure Category C |
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What is the prototypic neuraminidase inhibitor?
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Oseltamivir
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What is Oseltamivir effective against?
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Influenza A and B
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Oseltamivir treatment can begin at anytime in the course of the disease.
T or F |
False
Treatment must start early |
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What drug is used to treat Respiratory Syncytial Virus?
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Ribavirin
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What drug is used to prevent RSV?
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Palivizumab
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What are the contraindications of Ribavirin?
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Infants on ventilators
Lung deterioration Category X |
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Does PO acyclovir and valacyclovir have serious adverse effects?
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No
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