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25 Cards in this Set
- Front
- Back
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What are the twomajor sites of anti-influenza drug treatment
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-uncoating
-viral release |
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MOA of amantadine and rimantadine
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block M2 proton ion channel which prevents uncoating
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Spectrum of rimantadine
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-influenza A
-10X more active than amantadine |
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Zanamivir & oseltamivir
MOA spectrum |
-inhibits neuraminidase > virus release
-influenza A & B, avian, swine |
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What antiviral is used to treat RSV
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-ribavirin
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Ribavirin
MOA |
-purine nucleoside analog
-decreased RNA synthesis |
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What are three major drugs used to treat HSV and MOA
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-acyclovir, valacyclovir, famcicyclovir
-guanosine analogs |
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How must the "cyclovir" drugs be activated
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-monophosphorylated by thymidine kinase to inhibit viral DNA synthesis
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What is forscarnet use to treat
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herpes
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What are ganciclovir and valganciclovir and what do they treat
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-guanosine analogs
-CMV |
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What 4 drugs can be used to treat CMV
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-forscarnet
-ganciclovir -valganciclovir -cidofovir |
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Which two hepatitises can be treated w/drugs; have a vaccine
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-B and C
-A and B |
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What is the MOA of anti HBV drugs
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-nucleoside/nucleotide analogs
-lamivudine, telbivudine, adefovir, tenofovir, entecavir -inhibits DNA pol to suppress replication |
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T/F - antivirals eradicate viruses
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-false
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T/F - some antivirals have anti-HIV activity
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-true
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What is interferon
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-cytokine released by cells in response to a pathogen
-activates immune cells |
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What two drugs are used to treat HCV
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-interferon-a
-ribavirin |
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Nucleoside reverse transcriptase inhibitors:
-inhibit what -affects humans how -cause what |
-HIV1 or HIV2
-can inhibit human DNA pol gamma = decreased mitDNA synth -lactic acidosis |
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resistance to NRTI occurs slowly/quickly
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-slowly
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Where do non-nucleotide reverse transcriptase inhibitors bind
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-non-essential sites distant from enzyme catalytic site of RT
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T/F - there is cross resistance b/t NNRTI and NRTI
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-false
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Which antiretroviral drug is most susceptible to resistance
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-NNRTI
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SJS can occur w/ NRTI and NNRTI
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-only NNRTI
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MOA of protease inhibitors
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-inhibit protease responsible for cleaving polypeptides to produce final virus
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MOA of fusion inhibitor (enfuvirtide)
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-prevents fusion of virus membrane with the target cells
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