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7 Cards in this Set
- Front
- Back
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ANTI-PLATELET:
ASPIRIN |
Irreversible Inhibitor of COX-1
Inhibits formation of Thromboxane A2 Inhibits formation of Prostacyclin but endothelial cells can synthesize new COX but platelets cannot (no nuclei) |
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ANTI-PLATELET:
Clopidogrel Ticlopidine |
metabolized by CYP enzymes
block ADP (P2Y) receptors on platelets preventing further activation of platelets Ticlopidine can cause neutropenia |
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Glycoprotein IIb/IIIa Inhibitors:
Abciximab |
Binds to Gp IIb/IIIa receptors preventing the binding of aggregation factors (fibrinogen and Von Willebrand Factor)
very short half-life |
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Glycoprotein IIb/IIIa Inhibitors:
Tirofiban |
Binds and blocks Gp IIb/IIIa receptors
Short half life – duration of action ~ 4 hours Excreted unchanged by the kidneys |
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Glycoprotein IIb/IIIa Inhibitors:
Eptifibatide |
Binds and blocks Gp IIb/IIIa receptors
Short half-life |
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Glycoprotein IIb/IIIa Inhibitors:
Dipyridamole |
Type III Phophodiesterase Inhibitor blocking breakdown of cAMP and cGMP
Inhibitor of Adenosine deaminase leading to increased adenosine levels (antiplatelet effects) Inhibits Thromboxane Synthase |
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Glycoprotein IIb/IIIa Inhibitors:
Cilostazol |
Selective type III Phosphodiesterase Inhibitor
Increases cAMP (and cGMP) inhibits platelet aggregation Has favorable effects on Lipid Profile Indications: Intermittent Claudication, Buerger’s Syndrome, Chronic Cerebral Ischemia Side Effects: Diarrhea, Headache, Tachycardia Contraindications: CHF, nitrates, PDEI type V |
