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29 Cards in this Set
- Front
- Back
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Abacavir
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ABC
NRTI, Guanosine analog test for HLA-B*5701 --> hypersensitivity rxn 2nd line as drug #2/3 (in combo with lamivudine) |
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Tenofovir
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TDF (supplied as Tenofovir Disoproxil Fumarate)
NRTI, Adenosine analog 1st line as drug #2/3 (in combo with emtricitabine) renal impairment, decrease bone density (give Ca and Vit.D) |
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Emtricitabine
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FTC (FluoroThioCytidine)
NRTI, Cytidine analog 1st line with tenofovir as drug #2/3 |
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Lamivudine
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3TC (3'-ThiaCytidine)
NRTI, Cytidine analog 2nd line as drug #2/3 in combo with zidovudine |
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Didanosine
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ddI
NRTI, Adenosine analog 30min before/2hr after meal not used much (toxicities) GI intolerance, pancreatitis, peripheral neuropathy |
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Raltegravir
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RAL
Integrase Inhibitor 1st line as drug #1 |
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Ritonavir
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RTV
Protease Inhibitor but only used to boost other PI's. Most potent CYP3A4 inhibitor ever GI intolerance, hepatitis |
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Atazanavir
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ATV
PI increased bilirubin, kidney stones, kidney dysfxn first line as drug #1 (+ritonavir) |
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Darunavir
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DRV
PI take with food caution: SJS first line as drug #1 (+ritonavir) |
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Efavirenz
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EFV
NNRTI 1st line as drug #1 CNS SEs--> take without food |
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Zidovudine
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AZT (AZidoThymidine)
NRTI Thymidine analog 2nd line as drug #2/3 (in combo with lamuvidine) HA, GI intolerance, bone marrow suppression, myopathy |
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Etravirine
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ETR
NNRTI second line disperse in water |
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Lopinavir
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LPV
PI (preferred PI in pregnant women) GI intolerance, kidney 2nd line as drug #1 (+ ritonavir) |
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Nevirapine
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NVP
NNRTI 2nd line as drug #1 hepatotoxicity (may be severe/life-threatening), rash including SJS |
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Nelfinavir
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PI
diarrhea |
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Maraviroc
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MVC
CCR5 receptor antagonist; entry inhibitor CYP 3A4 substrate 2nd line as drug #1 |
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Enfurvitide
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T20
Fusion inhibitor injection site rxns, hypersensitivity not used much |
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RIlpivirine
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NNRTI
1 of 3 drugs in Complera take with full meal (>500 cal) do not take with acid suppression therapy QT prolongation |
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Truvada
(components) |
emtricitabine 200mg + tenofovir 300mg
2 x NRTI |
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Atripla
(components) |
efavirenz 600mg + emtricitabine 200mg + tenofovir 300mg
EFV + Truvada NNRTI + (2x NRTI) |
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Complera
(components) |
rilpivirine + tenofovir + emtricitabine
(rilpivirine + Truvada) NNRTI + (2 x NRTI) |
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ART associated ADRs?
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lactic acidosis
hepatic steatosis fat maldistribution hyperlipidemia osteonecrosis/penia/porosis rash |
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NRTIs
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abacavir
tenofovir didanosine zidovudine emtricitabine lamivudine |
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NNRTIs
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efavirenz
etravirine nevirapine rilpiverine |
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PIs
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atazanavir
lopinavir nelfinavir ritonavir darunavir |
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fusion inhibitors
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enfuvirtide
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CCR5 antagonist
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maraviroc
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integrase inhibitors
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raltegravir
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Prophylacyic Regimens
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Bacterial:
-pneumococcal: prevnar 13 -MAC: azithromycin 1200 mg once weekly if CD4 <50 Fungal: Candida, PCP - septra ss 1 tab daily (CD4 <200) Parasitic: toxoplas - septra ss 1 tab daily (CD4 <100) Viral: hep A/B vaccine if sero-ve |
