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34 Cards in this Set
- Front
- Back
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Abacavir
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ABC
NRTI, Guanosine analog 300mg PO bid test for HLA-B*5701 --> hypersensitivity rxn |
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Tenofovir
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TDF (supplied as Tenofovir Disoproxil Fumarate)
NRTI, Adenosine analog 300mg PO qd |
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Emtricitabine
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FTC (FluoroThioCytidine)
NRTI, Cytidine analog 200mg PO qd |
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Lamivudine
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3TC (3'-ThiaCytidine)
NRTI, Cytidine analog 300mg PO qd |
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Didanosine
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ddI
NRTI, Adenosine analog 250 (<60kg) 400mg (60+ kg) PO qd 30min before/2hr after meal |
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Raltegravir
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RAL
Integrase Inhibitor 400mg PO bid (800 if pt taking rifamycins) |
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Ritonavir
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RTV
Protease Inhibitor but only used to boost other PI's. Most potent CYP3A4 inhibitor ever |
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Atazanavir
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ATV
PI ATV 300mg + RTV 100mg PO qd 400mg with EFV |
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Darunavir
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DRV
PI DRV 600mg + RTV 100mg PO bid take with food caution: SJS |
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Efavirenz
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EFV
NNRTI 600mg PO qhs Freaky CNS sefx --> take without food |
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Zidovudine
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AZT (AZidoThymidine)
Thymidine analog 300mg PO bid |
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Stavudine
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d4T
NRTI, Thymidine analog 30-40mg PO bid do not combine with AZT |
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Etravirine
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ETR
NNRTI 200mg PO bid after meals |
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Fosamprenavir
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FPV
PI FPV 700mg + RTV 100mg PO bid boosting with RTV not absolutely necessary the PI least affected by anticonvulsants |
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Lopinavir
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LPV
PI (preferred PI in pregnant women) LPV 400mg + RTV 100mg PO bid |
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Nevirapine
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NVP
NNRTI 200mg PO BID |
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Saquinavir
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SQV
PI SQV 1gm + RTV 100mg PO bid after meal |
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Tipranavir
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TPV
PI TPV 500mg + RTV 200mg PO bid |
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Maraviroc
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MVC
CCR5 receptor antagonist; entry inhibitor 150mg PO bid with CYP3A4 inhibition (300mg without) |
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Enfurvitide
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T20
Fusion inhibitor 90mg inj SQ bid |
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Indinavir
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IDV
PI IDV 800mg + RTV 200mg PO bid |
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Delavirdine
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DLV
NNRTI 400mg PO tid not w/antacids |
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Truvada
(components) |
emtricitabine 200mg + tenofovir 300mg
(FTC + TDF) 2 x NRTI |
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Atripla
(components) |
efavirenz 600mg + emtricitabine 200mg + tenofovir 300mg
EFV + Truvada NNRTI + (2x NRTI) |
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Preferred regimen for pregnant women?
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LPV/r + AZT + 3TC
(PI + 2xNRTI) |
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M184V mutation
confers resistance to which ARV's? |
lamivudine (3TC)
emtricitabine (FTC) Cytidine analogs. |
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K65R mutation
confers resistance to which ARV's? |
abacavir
tenofovir didanosine |
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K103N mutation
confers resistance to which ARV's? |
efavirenz
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L90M mutation
confers resistance to which ARV's? |
Protease inhibitors in general
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When is a HIV+ pt considered to have AIDS?
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CD4 <350/uL
Has had an AIDS defining illness (OI) |
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Preferred PEP regimens (basic low risk and expanded high risk)?
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basic: AZT 300mg PO bid + 3TC 300mg PO bid
expanded: LPV/r 400mg/100mg PO bid + (AZT + 3TC as above) both for 28d same regimen as pregnant women |
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Preferred PrEP regimen?
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Truvada
emtricitabine 200mg + tenofovir 300mg PO qd |
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Pretty much everyone gets started on Truvada or Atripla. What is the exception and why?
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Pts with renal insufficiency
Tenofovir nephrotoxicity |
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Measurable goals of HAART tx?
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-HIV RNA < 50 copies/ml or “undetectable”
-Increased CD4 count both preferably within 4-6mos of starting tx |
