Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
27 Cards in this Set
- Front
- Back
|
Conventional antipsychotics differ how from typicals
|
Decrease + s/s
Increase - s/s Increase EPS Increase galactorrhea, bone demineralization, wt gain and sexual side effects |
|
|
Blocking dopamine in mesolimbic pathways does what
|
Decrease + s/s
|
|
|
Blocking dopamine in mesocortical pathways
|
Increase - s/s
|
|
|
Blocking dopamine in nigrostriatal pathway
|
EPS, Parkinsonia, and long term = TD
|
|
|
Blocking dopamine in Tubuloinfundibular
|
Increase prolactin=galactorrhea, bone demineralization, wt gain, sexual side effects
|
|
|
Blocking muscarinic cholinergic causes what
|
dry mouth, blurred vision, constipation, cognitive blunting, urine retention
|
|
|
Those medications with hi anticholinergic effects
|
have less EPS
|
|
|
Alph 1 adronergic
|
cardiovascular othostatic hypotension
|
|
|
Atypicals
How they work |
Serotonin dopamine antagonists
Serotonin 2A Dopamine 2 antagonist |
|
|
Atypicals
Nigrastriatal |
Increase dopamine when seratonin 2A is blocked
Decreased EPS |
|
|
Atypical
Mesocortical |
decrease - s/s
|
|
|
Atypical
Tuberoinfundibular |
Decrease prolactin
|
|
|
Atypical
Mesolimbic |
+ s/s improve
|
|
|
Resperidone becomes a typical when?
|
At higher doses
|
|
|
Resperidone improves what?
|
cognitive function, mood
|
|
|
Resperidone is used when?
|
Bipolar: manic and depressed
Schizophrenia when less wt gain is preferred. |
|
|
Olanzapine is used when?
|
difficult cases of schiz and Bipolar, depressed bipolar
|
|
|
Olanzapine is not used with who?
|
DM, Hyperlipidemia, obese, Hi LFT
|
|
|
Quetiapine has less sedative effects when?
|
Doses over 300mg
|
|
|
Quetiapine can cause what eye problem?
|
Cataracts and needs annual eye exams
|
|
|
Quetiapine is used with who?
|
Parkinson's psychosis, Bipolar and dementia
|
|
|
Ziprazidone is absorbed quicker when?
|
Taken with food
|
|
|
Ziprazidone differs from other atypicals how?
|
Serotonin 1D antagonist
Serotonin 1A agonist Inhibits seratonin and NE reuptake |
|
|
Ziprazidone used as what else other than antipsychotic?
|
Antidepressant and anxiolytic
|
|
|
Ziprazidone not used with what patients?
|
Those at risk for hypokalemia or hypo magnesemia; not after MI, not with CHF
Not with diuretics, burns, GI problems, hypoparathyroid, malnurished or ETOH Not with Lithium, mellaril, lavaquin, baxtrim, e-mycin due to elongation of QT interval. |
|
|
When may the dose of ziprazadone need increased or decreased due to meds?
|
Decreased if ketaconazole, erythromycin or some HIV meds
Increased when on mood stabilizer/anticonvulsants. |
|
|
When is ziprazadone used?
|
Bipolar with psychotic, manic s/s, rapid cycler and mized
|
