Antipsychotic Pharmacology For Med Students

Front 1

SE most associated with Olanzapine and Clozapine

Back 1

WEIGHT GAIN

Front 2

Weight gain and hyperglycemia (metabolic problems) are SE of which antipsychotics?

Back 2

Second Generation: Clozapine, Quetiapine, Olanzapine

Front 3

More EPS and less Sedative/Autonomic SE assoc w/:

Back 3

First Generation, High potency antipsychotics (Haloperidol, Fluphenazine)

Front 4

The 1st GEN, High Potency Antipsychotics:

Back 4

Haloperidol
Fluphenazine

Front 5

More Sedative/Autonomic Se and less EPS assoc w/:

Back 5

First Generation, Low potency antipsychotics (Chlorpromazine)

Front 6

First Gen, Low Potency antipsychotics (2):

Back 6

Chlorpromazine (Thorazine)
Thioridazine (Mellaril)

Front 7

Second Gen Antipsychotics (6):

Back 7

Risperidone
Clozapine
Quetiapine
Olanzapine
Ziprasidone (new)
Aripiprazole (new)

Front 8

D2 blockade vs. D2/5HT blockade:

Back 8

First gen vs. Second gen antipsychotics

Front 9

Why are 2nd gen antipsychotics being more used for Parkinson's nowadays?

Back 9

Lower incidence for extrapyramidal SE

Front 10

How to treat a pt with Manic Depression?

Back 10

AP drug + Lithium or Anticonvulsant

Front 11

How to treat a pt with depression AND agitation/psychotic delusions?

Back 11

Antidepressant + AP drug

Front 12

What produces the sedative SE of AP drugs?

Back 12

H1 blockade (anti-histamine action)

Front 13

A potent 2nd gen 5HT2A antagonist and 5HT1A agonist:

Back 13

Ziprasidone

Front 14

Ziprasidone's antagonism of 5HT-2A receptors limit which SE assoc with DA receptor blockade?

Back 14

Extra-Pyramidal Symptoms (EPS)

Front 15

Ziprasidone's high AGONIST activity on 5HT-1A makes it better than Clozapine and Olanzapine because:

Back 15

Better anxiolysis/antidepressant action

Front 16

Ziprasidone Px for ELDERLY vs Clozapine because:

Back 16

Weak anticholinergic activity (less M1 & H1 antagonism), so won't impair cognitive abilities (which tends to happen more in elderly)

Front 17

Can Improve blunted affect:

Back 17

Aripiprazole

Front 18

Possibility of Cataracts:

Back 18

Quetiapine

Front 19

High incidence of Agranulocytosis:

Back 19

Clozapine

Front 20

Better anxiolysis/antidepressant action, Low potential for impairing cognitive abilities

Back 20

Ziprasidone

Front 21

2nd gen AP drug with partial AGONIST activity at D2 and 5HT-1A receptors and ANTAGONIST activity at 5HT-2A receptors

Back 21

Aripiprazole

Front 22

Best 3 AP drugs to Tx psychosis in Alzheimer's b/c of dec. EPS:

Back 22

Clozapine
Olanzapine
Risperadone

Front 23

Unless the pt is elderly, you can be fairly sure that EPS assoc w/ AP drug Tx will go away because:

Back 23

Tolerance to EP effects develops, but not to AP effects

Front 24

AP drugs were once used as a form of torture for political prisoners because of this effect:

Back 24

Akathisia (restlessness)

Front 25

Dopamine's effect on Prolactin

Back 25

Inhibitory

Front 26

Effects with Tx of AP drugs:
1. Hypothalamus
2. Tuberoinfundibular
3. Anticholinergic
4. Antiadrenergic

Back 26

Inhibition of Dopamine with AP drug Tx causes:
1. poikilothermic state
2. Prolactin unregulated; males get gynecomastia, impotence; females gets galactorrhea or ammenorrhea
3. Antimuscarinic props cause persistant Sympathetic activation: dry mouth, tachycardia, constipation, blurred vision, urinary retention
4. alpha-1 blocking activity causes hypotension

Front 27

Only AP drug without antimuscarinic/anticholinergic properties:

Back 27

Risperidone

Front 28

D2 receptor blockers as anti-emetics:

Back 28

Phenothiazines (except Thioridazine), Benzamides (Metoclopramide, Trimethobenzamide)