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38 Cards in this Set

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Second generation antipsychotics

Clozapine (clorazil)


*can cause agranulocytosis


Need a WBC count



Risperdone (risperdal)


Olanzapine (zyprexa)


Ziprasidone (geodon)


Paliperidone (invega)


Iloperidone (fanapat)


Asenapine (saphris)


Lurasidone (latuda)

Third generation antipsychotics

Aripiprazole (abilify)

Mechanisms of action for Antipsychotics

Block receptors for the neurotransmitter dopamine


First generation have more side effects


Third generation is a dopamine system stabilizer

First generation antipsychotics

Chlorpromazine (Thorazine)


Perphenazine (Trilafon)


Fluphenazine (Prolixin)


*depot injection


Thioridazine (Mellaril)


*May lengthen the QT interval causing cardiac dysrhythmias


Mesoridazine (Serentil)


*may lengthen the QT interval causing cardiac dysrhythmias


Trifluoperazine (stelazine)



Side effects of antipsychotics

Extrapyramidal symptoms


Neuroleptic malignant syndromes


Tardive Dyskinesia


Dry mouth, blurred vision, urinary hesitation or retention.

Antidepressant drugs (what do they treat)

Used to treat major depressive illness, anxiety disorders and the depressed phase of bipolar disorder and psychotic depression. Treat chronic pain, migraine headaches, sleep apnea, panic disorder and eating disorders

SSRIs

Fluoextine (Prozac)


Fluvoxamine (Luvox)


Paroextine (Paxil)


Sertraline (Zoloft)


Citalopram (Celexa)


Escitalopram (Lexapro)

Cyclic compounds (anti-depressants)

Imipramine (Tofranil)


Desipramine (Norpramine)


Amitriptyline (Elavil)


Nortriptyline (pamelor)


Doxepin (Sinequan)


Trimipramine (Surmontil)


Protriptyline (Vivactil)


Maprotiline (Ludiomil)


Mirtazapine (Remeron)


Amoxapine (Asendine)


Clomipramine (Anafranil)

Other antidepressant compound meds

Bupropion (Wellbutrin)


*can cause seizures


Venlafaxine (Effexor)


Desvenlafaxine (pristiq)


Trazadone (desyel)


*may cause priapism


Nefazodone (serzone)


*may cause life threatening liver damage


Duloxetine (cymbalta)

MAOIs

Pheneizine (Nardil)


Tranylcpromine (parnate)


Isocarbixazid (marplan)

Mechanism of action for antidepressants

Major interaction in norepinephrine, dopamine, and serotonin in the brain

Side effects of SSRIs

Anxiety, agitation, akathsia, nausea, insomnia, difficulty getting an erection and an orgasm, weight gain, sweating, headaches

Side effects of cyclics

Dry mouth, constipation, urinary hesitancy, dry nasal passages, blurred near vision, agitation, sexual dysfunction, tachycardia, weight gain

Side effects of MAOIs

Daytime sedation, insomnia, weight gain, sexual dysfunction, orthostatic hypotension.

Inhibition of MAOIs results in....

Increased serum tyramine levels which lead to hypertension, hyperpyrexia, tachycardia, tremulousness, and diaphoresis.

Serotonin syndrome can occur when.....

Taking an MAOI and a SSRI at the same time or too close to the end of each's therapy.

Symptoms of Serotonin syndrome

Agitation, sweating, fever, tachycardia, hypotension, coma, and even death.

When should SSRIs be taken

In the morning unless sedation is a problem

How many hours after can a dose of SSRI be taken

Up to 8 hours

How many hours after can a dose of cyclic be taken

Up to 3 hours

Foods to avoid while taking MAOIs

Food with tyramine, (cheese, beer, aged meats)

Mood stabilizing drugs

Used to treat bipolar disorder by stabilizing the clients mood preventing or minimizing the highs and lows and treating acute episodes of mania

Types of mood stabilizing drugs

Lithium


Anticonvulsants....


Lamotrigine


Carbamzepine (Tegretol)


*can cause aplastic anemia and agranulocytosis


Valporic acid (depakote)


*Can cause hepatic failure


Gabapentin (neurontin)


Topiramate (topamax)


Oxcarbazepine (trileptal)


Lamotrigine (lamictal)

Mechanism of action for lithium

Lithium normalizes the reputable of certain neurotransmitters such as serotonin, norepinephrine, acetylcholine, and dopamine.

Mechanism of action for valporic acid (depakote) and topiramate (topamax)

Known to increase levels of the inhibitory neurotransmitter GABA

Side effects of lithium

Moms nausea, weight gain, acne, vomiting, muscle weakness, lack of coordination, acne, anorexia, metallic taste in mouth.

Anti-anxiety drugs (anxiolytics)

Used to treat anxiety and anxiety disorders, insomnia, OCD, depression, PTSD and alcohol withdrawal.

Benzodiazepines

Alprazolam (Xanax)


Chlordiazepoxide (Librium)


Clonazepam (Klonopin)


Diazepam (Valium)


Flurazepam (Dalmane)


Lorazepam (Ativan)


Oxazepram (Serax)


Tamezepam (Restoril)


Triazolam (halcion)

Mechanism of action of anxiolytics

Mediate the actions of the amino acid GABA

Side effects of benzodiazepines

Physical dependence, drowsiness, sedation, poor coordination, impaired memory, and clouded sensorium

Non-benzodiazepines

Busprione (buSpar)

Side effects of non-benzodiazepines

Dizziness, sedation, nausea, headache

Alcohol and anxiolytics

Do not intake large amounts of alcohol while on them

Amphetamines (stimulant drugs)

Used to treat ADHD in children and adolescents and narcolepsy

types of amphetamines (stimulant drugs)

Methylphenidate (Ritalin)


Amphetamine (Adderall)


Pemoline (Cylert)


*can cause liver failure in four weeks from beginning therapy.


Atomoxetine (stratter)

Mechanism of action for amphetamines (stimulant drugs)

They act by causing the release of norepinephrine, serotonin, and dopamine. They also block the reuptake of these transmitters

Side effects of amphetamines (stimulant drugs)

Anorexia, weight loss, nausea, irritability, dizziness, dry mouth, blurred vision, and palpitations. Growth and wait suppression occurs in children

While taking amphetamines avoid....

Caffeine, chocolate and sugar. Potential for abuse is high with amphetamines, may lead to dependence