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28 Cards in this Set
- Front
- Back
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too much dopamine specifically in
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D1 Mesolimbic-mesocortical pathway, related to behavior
-too much dopamine |
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DOPAMINERGIC SYSTEMS
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Five important pathways.
Mesolimbic-mesocortical pathway, related to behavior Nigrostriatal is involved in the coordination of voluntary movement. Tuberoinfundibular - Dopamine released by these neurons physiologically inhibits prolactin secretion. Medullary-periventricular pathway - may be involved in eating behavior. Incertohypothalamic pathway - appears to regulate the anticipatory motivational phase of copulatory behavior in lab animals. |
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ALL ANTIPSYCHOTIC DRUGS side effects
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D2; loss of voluntary muscle movement (drug induced parkinsonism; benzotropin)
-mesolimbic-mesocortical pathway; inhibits prolactin -in woman; starts lactating, inhibits LH; no ovulation; infertility -men; gynomalstia; infertility |
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Classical or typical antipsychotics drugs
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-prob is too TOO MUCH dopamine
-ONLY observe positive symptoms -positive symptoms; something ‘extra’ can talk to radio |
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Atypical antipsychotics drugs
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-prob is TOO MUCH dopamaine AND serotine
positive symptoms AND some negative symptoms -positive symptoms; something ‘extra’ can talk to radio --negative symptoms; missing ‘something’ social withdrawal, being alone etc, MC Q asked LOSS of inhibition (sitting in class, start barking) |
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Traditional antipsychotics (typical)
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-Phenothiazines (all low potency)
Chlorpromazine- deposited in eye, visual disturbance cornia Thioridazine- depsoits in retina Trifluoperazine Fluphenazine (high potency) -Nonphenothiazines( all high potency) Loxapine Haloperidol Molindone Thiothixene |
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Nonphenothiazines( all high potency)
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bind and block dopamine receptors very well- antagonist blockers; due to their strong binding; will bind to all other dopamine receptors aswell
-side effects parkinsons like syndrome (d2 block) -hyperprolactemia (d3 blockage) -shoveling gait, infertility, ganomasactomia |
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Phenothiazines (all low potency)
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binds not that well, need to give higher dose; binds less to other dopamine receptors, BUT DOES bind to;
histamine receptors (on mast cells); cause sedation block alpha 1 receptors; smooth muscle dilation; orthostatic hypotension blocks muscarinic receptors; MC N1 blockage- dry mouth n dry eyes |
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Q; ptn w/ psyhosis treated w/ drug and now complaining of sedation, drug given?
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-low poteny
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Q; ptn treated, complaints that cannot conceive;
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-must be high potency drug
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Blockade in Mesocortical-mesolimbic pathway
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leads to antipsychotic effect
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Nigrostriatal pathway:
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movement disorders (Parkinsonisms)
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Tuberoinfundibular pathway:
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hyperprolactinemia
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ptn treated w/ antipschotic drug, develops parkinsonism, treated w/ benzotropine, which anti-psychotic was he treated w?
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high potency
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Tourette Syndrome DOC is
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haloperidol
-q will say “cousin, dad or someone WILL have ADHD” |
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P; ptn has tardive dyskinesia, drug?
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High potency
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Neuroleptic malignant syndrome (NMS)
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Only drug that can do it is Haloperidol
-ONLY happen to those with genetic def on rydinal receptors -lots of calicum released from sarcoplasmic reticulum, causes temp to go up, sweating, hyperthermia Treated w/ Dantrolene |
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Atypical antipsychotics
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Clozapine
Risperidone Olanzepine Ziprasidone MOA: Mainly because of blockade of Dopamine D2, & Serotonin 5-HT2 receptors Faster dissociation from the Dopamine receptors Lesser ADR related to dopamine blockade Treats positive and negative symptoms |
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UNIQUE side effect; weight gain and glucose tolerance
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Clozapine & Olanzapine
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Chlorpromazine
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deposited in eye, visual disturbance
cornia Traditional antipsychotics (typical) low potency |
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Trifluoperazine
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Traditional antipsychotics (typical) low potency
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Fluphenazine
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high potency
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Loxapine
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high potency
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Haloperidol
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high potency
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Molindone
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high potency
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Thiothixene
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high potency
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ending that tells you it is a low potent
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-azine
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Thioridazine-
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depsoits in retina
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