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5 Cards in this Set
- Front
- Back
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Ionophores
(Monensin ) MOA 3 uses. 1 BIG con! |
1.Anticoccidial
MOA: Lipophilic drugs that complex with cations and then transport these into the coccidium. Osmolality is altered and coccidia are incapable of osmoregulation leading to death Used as anticoccidial preventation 2.Growth Promotant Improves ruminal efficiency by increasing propionic acid relative to acetic and butyric acid. Main use is in growing dairy cows and feedlot finishers 3.Anti-bloat :Decreases methane production Not In Horses! Cardiac myocytes are particularly sensitive to cation influx |
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Potentiated Sulphonamides. 5 points
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Protozoa must synthesise their own folate
• Sulphonamides & Trimethoprim are both folate synthesis inhibitors • Primary use is for production animal coccidiosis and small animal toxoplasmosis • Coccidiostats / Coccidiocides depending upon which TMS-coccidia combination • Used commonly in-water • Wide resistance profiles |
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Toltrazuril. 6 points
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Antiprotozoal
• Coccidiocidal inhibits nuclear division and mitochondrial activity during intracellular stages of lifecycle does not effect extracellular stages of lifecycle allowing immunity to improve • Used predominantly for coccidiosis in intensively raised animals 100d meat WHP for pigs |
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Clindamycin
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Able to inhibit protozoal protein synthesis
Used for treating feline and canine toxoplasmosis |
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Metronidazole
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Antiprotozoal doses higher than antibiotics.
Effective against trichomonas – avian (budgie): crop, vomiting |
